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- Pharmacology For Dextromethorphan + Triprolidine + Pseudoephedrine
Dextromethorphan + Triprolidine + Pseudoephedrine Pharmacology
Dextromethorphan + Triprolidine + Pseudoephedrine
About Dextromethorphan + Triprolidine + PseudoephedrineN/AMechanism of Action of Dextromethorphan + Triprolidine + PseudoephedrineN/APharmacokinets of Dextromethorphan + Triprolidine + PseudoephedrineN/AOnset of Action for Dextromethorphan + Triprolidine + PseudoephedrineN/ADuration of Action for Dextromethorphan + Triprolidine + PseudoephedrineN/AHalf Life of Dextromethorphan + Triprolidine + PseudoephedrineN/ASide Effects of Dextromethorphan + Triprolidine + PseudoephedrineN/AContra-indications of Dextromethorphan + Triprolidine + PseudoephedrineN/ASpecial Precautions while taking Dextromethorphan + Triprolidine + PseudoephedrineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dextromethorphan + Triprolidine + PseudoephedrineN/AInteractions for Dextromethorphan + Triprolidine + PseudoephedrineN/ATypical Dosage for Dextromethorphan + Triprolidine + PseudoephedrineN/ASchedule of Dextromethorphan + Triprolidine + PseudoephedrineN/AStorage Requirements for Dextromethorphan + Triprolidine + PseudoephedrineN/AEffects of Missed Dosage of Dextromethorphan + Triprolidine + PseudoephedrineN/AEffects of Overdose of Dextromethorphan + Triprolidine + PseudoephedrineN/ADextromethorphan
About DextromethorphanA synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.Mechanism of Action of DextromethorphanDextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))Pharmacokinets of DextromethorphanAbsorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.Onset of Action for DextromethorphanBelow ? an hourDuration of Action for Dextromethorphan3 to 6 hoursHalf Life of Dextromethorphan11 hoursSide Effects of Dextromethorphan1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.Contra-indications of DextromethorphanPatients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.Special Precautions while taking Dextromethorphan1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationMay be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for DextromethorphanChronic nonproductive cough.Interactions for DextromethorphanN/ATypical Dosage for DextromethorphanOral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of DextromethorphanN/AStorage Requirements for DextromethorphanStore at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of DextromethorphanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextromethorphanRemove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.Triprolidine
About TriprolidineFirst generation histamine H1 antagonist, Alkylamine derivative, Antihistamine.Mechanism of Action of TriprolidineTriprolidine hydrochloride exerts it`s action by acting as an H1 receptor antagonist. It antagonizes most of the pharmacological actions of Histamine and reduces allergic symptoms. It also has anticholinergic properties and reduces secretions
Pharmacokinets of TriprolidinePharmacokinetics: Absorption: Well absorbed orally, Distribution: Widely distributed in the body, Metabolism: Metabolized in the body by carboxylation in to metabolites,
Excretion: Excreted through urine.Onset of Action for TriprolidineN/ADuration of Action for TriprolidineN/AHalf Life of TriprolidineN/ASide Effects of Triprolidine1. Sedation
2. Inability to concentrate
3. Diminished alertness
4. Motor incordination
5. Fatigue
6. Insomnia
7. Somnolence
8. Dry mouth
9. Urinery hesitancy
10. Alterd bowel movement
11. Orthostatic hypotension
12. Palpitations
13. Tachycardia
14. Drowsiness
15. Dizziness
16. Excitation
17. Headache
18. Nervousness
19. Blurred vision
20. Nasal stuffiness
21. Anorexia
22. Epigastric distress
23. Nausea
24. Vomiting
25. Diarrhea
26. Constipation
27. Thickening of bronchial secretions
Contra-indications of Triprolidine1. Hypersensitivity to the drug
2. Coronary insufficiency
3. Hypertension
4. Prostatism
5. Thyrotoxicosis
6. Bladder dysfunction
7. Narrow angle glaucoma
8. Phaeochromocytoma
9. Asthma
Special Precautions while taking Triprolidine1. Driving or any work requiring mental alertness
2. Peptic ulcer
3. Pyloroduodenal obstruction
4. Prostatic hypertrophy
5. Bladder neck obstruction
6. Urinary retention
7. Increased intraocular pressure
8. Hyperthyroidism
9. Sleep apnea
10. Cardiovascular disease
11. Along with other medication
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Triprolidine1. Common cold
2. Allergic respiratory diseases
3. Runny nose
4. Sneezing
5. Itchy nose and throat
6. Itchy,watery eyes
7. Cough
Interactions for TriprolidineN/ATypical Dosage for TriprolidineOral: 2.5 to 5mg dosage forms are availableSchedule of TriprolidineGStorage Requirements for TriprolidineStore at room temperature at a range of 15 to 30 degree C. Protect from light, heat, and moisture.Effects of Missed Dosage of TriprolidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TriprolidineProvide symptomatic treatment and supportive measures. Pseudoephedrine
About PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
Home Delivery for Dextromethorphan + Triprolidine + Pseudoephedrine in Your City
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Dextromethorphan + Triprolidine + Pseudoephedrine is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + triprolidine + pseudoephedrine might be better known than dextromethorphan + triprolidine + pseudoephedrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + triprolidine + pseudoephedrine in stock, you can ask for one of the branded alternatives for dextromethorphan + triprolidine + pseudoephedrine.