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- Pharmacology For Dextromethorphan + Phenylpropanolamine + Triprolidine
Dextromethorphan + Phenylpropanolamine + Triprolidine Pharmacology
Dextromethorphan + Phenylpropanolamine + Triprolidine
About Dextromethorphan + Phenylpropanolamine + TriprolidineN/AMechanism of Action of Dextromethorphan + Phenylpropanolamine + TriprolidineN/APharmacokinets of Dextromethorphan + Phenylpropanolamine + TriprolidineN/AOnset of Action for Dextromethorphan + Phenylpropanolamine + TriprolidineN/ADuration of Action for Dextromethorphan + Phenylpropanolamine + TriprolidineN/AHalf Life of Dextromethorphan + Phenylpropanolamine + TriprolidineN/ASide Effects of Dextromethorphan + Phenylpropanolamine + TriprolidineN/AContra-indications of Dextromethorphan + Phenylpropanolamine + TriprolidineN/ASpecial Precautions while taking Dextromethorphan + Phenylpropanolamine + TriprolidineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Dextromethorphan + Phenylpropanolamine + TriprolidineN/AInteractions for Dextromethorphan + Phenylpropanolamine + TriprolidineN/ATypical Dosage for Dextromethorphan + Phenylpropanolamine + TriprolidineN/ASchedule of Dextromethorphan + Phenylpropanolamine + TriprolidineN/AStorage Requirements for Dextromethorphan + Phenylpropanolamine + TriprolidineN/AEffects of Missed Dosage of Dextromethorphan + Phenylpropanolamine + TriprolidineN/AEffects of Overdose of Dextromethorphan + Phenylpropanolamine + TriprolidineN/ADextromethorphan
About DextromethorphanA synthetic morphine (((dextrorotatory methyl ether of Levorphanol))) derivative,A synthetic narcotic antitussive.Mechanism of Action of DextromethorphanDextromethorphan hydrobromide is a selective antitussive which raises threshold of cough centre and suppresses the cough reflex by direct action on the cough centre in the medulla. It does not depress mucociliary function of the airway mucosa and is also devoid of constipating and addicting actions. (((Its antitussive action is not exerted through opioid receptors)))Pharmacokinets of DextromethorphanAbsorption: Well absorbed orally, Metabolism: Extensively metabolized by liver, Excretion: Excreted primarily through urine as metabolites; about 7 to 10% is excreted through faeces.Onset of Action for DextromethorphanBelow ? an hourDuration of Action for Dextromethorphan3 to 6 hoursHalf Life of Dextromethorphan11 hoursSide Effects of Dextromethorphan1. Dizziness
2. Nausea
3. Vomiting
4. Stomach pain
5. Drowsiness
6. Ataxia.Contra-indications of DextromethorphanPatients currently taking MAO inhibitors or within two weeks of discontinuing MAO inhibitors.Special Precautions while taking Dextromethorphan1. Atopic children
2. Sedated or deliberate patients
3. Those patients confined to the supine position
4. Patients sensitive to aspirin
Pregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationMay be used
Children below 2 years: Syrup, tablets, or lozenges are contraindicated
Indications for DextromethorphanChronic nonproductive cough.Interactions for DextromethorphanN/ATypical Dosage for DextromethorphanOral:
Chronic nonproductive cough:
Adults and children above 12 years: 10 to 20mg every 4 hours; or 30mg three to four times daily.
Maximum dose: 120mg daily.
Children (((age 6 to 12))): 5 to 10mg every four hours
Maximum dose: 60mg daily
Children (((age 2 to 6))): 2.5 to 5mg every four hours.
Maximum dose: 30mg daily.
Schedule of DextromethorphanN/AStorage Requirements for DextromethorphanStore at room temperature in a well closed light resistant container. Protect from excess heat and moisture. Keep out of reach of children.Effects of Missed Dosage of DextromethorphanTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of DextromethorphanRemove drug from the body by administration of activated charcoal and provide symptomatic treatment and supportive measures.Phenylpropanolamine
About PhenylpropanolamineAlfa-and Beta-adrenergic agonist, Phenethylamine derivative, a stimulant, decongestant,anorectic.Mechanism of Action of PhenylpropanolamineIt is a mixed acting sympathomimetic amine with predominant alpha adrenergic agonistic action. It exerts nasal decongestant action by acting through alpha adrenergic receptors in the respiratory tract mucosa; and produces vasoconstriction. It temporarily reduces the swelling associated with inflammation of nasal mucosa.
Phenylpropanolamine also suppresses the appetite control center in the hypothalamus
Pharmacokinets of PhenylpropanolamineAbsorption: Well absorbed orally, Metabolism: Metabolized in to an active metabolite in liver, Excretion: Excreted mainly through urine.Onset of Action for Phenylpropanolamine15 to 30 minutesDuration of Action for Phenylpropanolamine3 hoursHalf Life of PhenylpropanolamineN/ASide Effects of Phenylpropanolamine1. Hypertension
2. Stroke
3. Arrhythmias
4. Renal failure
5. Rhabdomyolysis
6. Psychotic disturbances
7. Hallucinations
8. SeizuresContra-indications of Phenylpropanolamine1. Hypersensitivity to Phenylpropanolamine or other sympathomimetics
2. Coronary artery disease
3. Hypertension
4. Arteriosclerosis
5. Depression
6. Angle-closure glaucoma
7. Diabetes
8. Renal impairment
9. Hyperthyroidism
10. During or within 14 days of use of MAO inhibitors
11. Use as an anorexiant for children less than 12 years of age
12. Sustained-release forms during lactation and in children less than 12 years of age
Special Precautions while taking Phenylpropanolamine1. Cardiovascular disorders
2. Mild Hypertension
3. Prostatic hypertrophy
4. Psychosis or other psychiatric disorders (Phenylpropanolamine may precipitate psychiatric disorders)
5. Not drinking large amounts of caffeine-containing beverages, such as coffee, tea, or colas
6. Do not engage in driving, using machines, or doing anything else that requires mental alertness while taking medication
7. Inform the physician if cold symptoms do not improve within 7 days or if fever is present
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Phenylpropanolamine1. Nasal congestion
Interactions for PhenylpropanolamineN/ATypical Dosage for PhenylpropanolamineOral:
Adults:
As decongestant: 25mg every four hours or 50mg every 8 hours daily. Not to exceed 150mg/day
Anorexiant: 25mg thrice daily; 30minutes before meals.
Extended release tablets or capsules:As decongestant: 75mg twice daily
Anorexiant: 75mg once daily in the morning.
As decongestant:
Children (6 to 12 years): 12.5mg up to every four hours. Not to exceed 75mg/day
Children (2 to 6years): 6.25mg up to every four hours. Not to exceed 37.5mg/day
Schedule of PhenylpropanolamineHStorage Requirements for PhenylpropanolamineStore at controlled room temperature at range of 15 to 30 degree C.; in a well closed container. Protect from light.Effects of Missed Dosage of PhenylpropanolamineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of PhenylpropanolamineProvide symptomatic treatment and supportive measures.Remove drug from the body by induced emesis or gastric lavage. Barbiturate sedatives are sometimes used to control excessive CNS stimulation. Monitor Cardiovascular and respiratory functions. Administer intravenous fluids to control hypotension. Correct hypertension with Intravenous phentolamine or nitrates. Perform forced diuresis by acidification of urine.
Triprolidine
About TriprolidineFirst generation histamine H1 antagonist, Alkylamine derivative, Antihistamine.Mechanism of Action of TriprolidineTriprolidine hydrochloride exerts it`s action by acting as an H1 receptor antagonist. It antagonizes most of the pharmacological actions of Histamine and reduces allergic symptoms. It also has anticholinergic properties and reduces secretions
Pharmacokinets of TriprolidinePharmacokinetics: Absorption: Well absorbed orally, Distribution: Widely distributed in the body, Metabolism: Metabolized in the body by carboxylation in to metabolites,
Excretion: Excreted through urine.Onset of Action for TriprolidineN/ADuration of Action for TriprolidineN/AHalf Life of TriprolidineN/ASide Effects of Triprolidine1. Sedation
2. Inability to concentrate
3. Diminished alertness
4. Motor incordination
5. Fatigue
6. Insomnia
7. Somnolence
8. Dry mouth
9. Urinery hesitancy
10. Alterd bowel movement
11. Orthostatic hypotension
12. Palpitations
13. Tachycardia
14. Drowsiness
15. Dizziness
16. Excitation
17. Headache
18. Nervousness
19. Blurred vision
20. Nasal stuffiness
21. Anorexia
22. Epigastric distress
23. Nausea
24. Vomiting
25. Diarrhea
26. Constipation
27. Thickening of bronchial secretions
Contra-indications of Triprolidine1. Hypersensitivity to the drug
2. Coronary insufficiency
3. Hypertension
4. Prostatism
5. Thyrotoxicosis
6. Bladder dysfunction
7. Narrow angle glaucoma
8. Phaeochromocytoma
9. Asthma
Special Precautions while taking Triprolidine1. Driving or any work requiring mental alertness
2. Peptic ulcer
3. Pyloroduodenal obstruction
4. Prostatic hypertrophy
5. Bladder neck obstruction
6. Urinary retention
7. Increased intraocular pressure
8. Hyperthyroidism
9. Sleep apnea
10. Cardiovascular disease
11. Along with other medication
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Triprolidine1. Common cold
2. Allergic respiratory diseases
3. Runny nose
4. Sneezing
5. Itchy nose and throat
6. Itchy,watery eyes
7. Cough
Interactions for TriprolidineN/ATypical Dosage for TriprolidineOral: 2.5 to 5mg dosage forms are availableSchedule of TriprolidineGStorage Requirements for TriprolidineStore at room temperature at a range of 15 to 30 degree C. Protect from light, heat, and moisture.Effects of Missed Dosage of TriprolidineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TriprolidineProvide symptomatic treatment and supportive measures. Home Delivery for Dextromethorphan + Phenylpropanolamine + Triprolidine in Your City
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Dextromethorphan + Phenylpropanolamine + Triprolidine is a generic medicine name and there are several brands available for it. Some of the brands for dextromethorphan + phenylpropanolamine + triprolidine might be better known than dextromethorphan + phenylpropanolamine + triprolidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dextromethorphan + phenylpropanolamine + triprolidine in stock, you can ask for one of the branded alternatives for dextromethorphan + phenylpropanolamine + triprolidine.