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- Pharmacology For Codeine + Chlorpheniramine Maleate
Codeine + Chlorpheniramine Maleate Pharmacology
Codeine + Chlorpheniramine Maleate
About Codeine + Chlorpheniramine MaleateN/AMechanism of Action of Codeine + Chlorpheniramine MaleateN/APharmacokinets of Codeine + Chlorpheniramine MaleateN/AOnset of Action for Codeine + Chlorpheniramine MaleateN/ADuration of Action for Codeine + Chlorpheniramine MaleateN/AHalf Life of Codeine + Chlorpheniramine MaleateN/ASide Effects of Codeine + Chlorpheniramine MaleateN/AContra-indications of Codeine + Chlorpheniramine MaleateN/ASpecial Precautions while taking Codeine + Chlorpheniramine MaleateN/APregnancy Related InformationContraindicated; since Codeine and Chlorpheniramine Maleate are contraindicated in pregnancy, the combination generic cannot be used in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationContraindicated; since Chlorpheniramine Maleate is contraindicated in breast feeding; the combination generic cannot be used in breast feeding mother.Children Related InformationN/AIndications for Codeine + Chlorpheniramine MaleateCoughInteractions for Codeine + Chlorpheniramine MaleateN/ATypical Dosage for Codeine + Chlorpheniramine MaleateAdult: 5 ml to be taken 3 - 4 times dailySchedule of Codeine + Chlorpheniramine MaleateN/AStorage Requirements for Codeine + Chlorpheniramine MaleateN/AEffects of Missed Dosage of Codeine + Chlorpheniramine MaleateN/AEffects of Overdose of Codeine + Chlorpheniramine MaleateN/ACodeine
About CodeineAn opiate, methylmorphine , Narcotic analgesic, antitussive, and antidiarrheal.Mechanism of Action of CodeineCodeine exerts it`s action through opioid receptors and posses antitussive properties. It selectively and directly acts on cough centre and suppresses cough. It also posses analgesic action due to it`s agonistic action on opioid receptors.Pharmacokinets of CodeineAbsorption: Well absorbed after oral and parenteral administration. Distribution: Widely distributed in the body; it crosses placenta and also enters in to the breast milk. Metabolism: Metabolized in the liver by demethylation and glucuronide conjugation, Excretion: Excreted mainly in the urine as nor codeine and free and conjugated morphine.Onset of Action for CodeineOral: 30 to 45 minutes
I.V.: Rapid
I.M.: 10 to 30 minutes
S.C.: 10 to 30 minutes
Duration of Action for CodeineOral: 4 to 6 hours
I.V.: 4 to 6 hours
I.M.: 4 to 6 hours
S.C.: 4 to 6 hours
Half Life of CodeineN/ASide Effects of Codeine1. Constipation
2. Nausea
3. Vomiting
4. Drymouth
5. Respiratory depression
6. Hypotension
7. Bradycardia
8. Dizziness
9. Sedation
10. Euphoria
11. Urine retention
12. Flushing
13. Pruritus
14. Diaphoresis
15. Physical dependence.Contra-indications of Codeine1. Hypersensitivity to the drug
2. Bronchial asthma
3. Increased intracranial pressure
4. Respiratory depression
5. Paralytic ileus
6. Head injury
7. Alcoholism
8. Diverticulitis
9. Following bowel surgery.Special Precautions while taking Codeine1. Renal impairment
2. Hepatic impairment
3. Increased CSF pressure
4. Hypothyroidism
5. Addison`s disease
6. COPD
7. In deliberate individuals
8. Prostatic hypertrophy
9. Epilepsy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Codeine1. Nonproductive cough
2. Mild to moderate pain.Interactions for CodeineN/ATypical Dosage for CodeineAdults:
Oral:
Nonproductive cough:10 to 20mg 4 times daily;Maximum dose: 120mg/day
Oral, S.C., I.M.:
Mild to moderate pain:15 to 60mg Orally, S.C., or I.M.;4 to 6 times daily as required by the patient.
Children:
Oral:
Nonproductive cough:
Over 12 years: 10 to 20mg 4 times daily
Age 6 to 12: 5 to 10mg 4 times daily;Maximum dose: 60mg/day
Age 2 to 6: 1mg/kg/day as four equally divided doses and do not exceed 30mg in 24 hours.
Oral, S.C., I.M.:
Mild to moderate pain:0.5mg/kg orally every 4 to 6 hours or 0.5mg/kg S.C. or I.M.
Schedule of CodeineHStorage Requirements for CodeineStore at controlled room temperature at a range of 15 to 30 degree C and protects from light.Effects of Missed Dosage of CodeineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of CodeineEstablish adequate respiratory exchange via a patent airway and ventilation as needed. Administer opioid antagonist Naloxone to reverse respiratory depression use repeatedly as required. (Naloxone shouldn`t be administered unless patient has clinically significant respiratory or cardiovascular depression.). If patient shows signs and symptoms within 2 hours of ingestion empty the stomach by gastric lavage and induced emesis. Reduce absorption by administration of activated charcoal. Closely monitor vital parameters and correct fluid and electrolyte balance. Provide symptomatic and supportive treatment.Chlorpheniramine Maleate
About Chlorpheniramine MaleateN/AMechanism of Action of Chlorpheniramine MaleateN/APharmacokinets of Chlorpheniramine MaleateN/AOnset of Action for Chlorpheniramine MaleateN/ADuration of Action for Chlorpheniramine MaleateN/AHalf Life of Chlorpheniramine MaleateN/ASide Effects of Chlorpheniramine MaleateN/AContra-indications of Chlorpheniramine MaleateFirst Generation alkylamine H1 Antagonist, Antihistamine.Special Precautions while taking Chlorpheniramine MaleateN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Chlorpheniramine MaleateN/AInteractions for Chlorpheniramine MaleateN/ATypical Dosage for Chlorpheniramine MaleateN/ASchedule of Chlorpheniramine MaleateN/AStorage Requirements for Chlorpheniramine MaleateN/AEffects of Missed Dosage of Chlorpheniramine MaleateN/AEffects of Overdose of Chlorpheniramine MaleateN/AHome Delivery for Codeine + Chlorpheniramine Maleate in Your City
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Codeine + Chlorpheniramine Maleate is a generic medicine name and there are several brands available for it. Some of the brands for codeine + chlorpheniramine maleate might be better known than codeine + chlorpheniramine maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have codeine + chlorpheniramine maleate in stock, you can ask for one of the branded alternatives for codeine + chlorpheniramine maleate.