Dexchlorpheniramine Maleate Pharmacology

Dexchlorpheniramine Maleate

About Dexchlorpheniramine Maleate
First Generation H1 Antagonist , Alkylamine derivative, Antihistamine.
Mechanism of Action of Dexchlorpheniramine Maleate
Dexchlorpheniramine exerts its action by acting as an H1 receptor antagonist. It antagonizes most of the pharmacological actions of Histamine and reduces allergic symptoms. It also has anticholinergic properties and reduces secretions.
Pharmacokinets of Dexchlorpheniramine Maleate
Absorption: Slowly absorbed orally, bioavailability is about 25 to 50%. Distribution: Widely distributed in a protein bound form, Metabolism: Extensively metabolized in the body, Excretion: Excreted through urine both as metabolites and parent drug.
Onset of Action for Dexchlorpheniramine Maleate
N/A
Duration of Action for Dexchlorpheniramine Maleate
4 - 8 hours
Half Life of Dexchlorpheniramine Maleate
20 to 24 hours
Side Effects of Dexchlorpheniramine Maleate
1.Sedation
2.Sleepiness
3.Dizziness
4.Motor incordination
5.Fatigue
6.Confusion
7.Restlessness
8.Nervousness
9.Excitation
10.Insomnia
11.Euphoria
12.Paresthesias
13.Blurred vision
14.Diplopia
15.Anorexia
16.Nausea
17.Vomiting
18.Epigastric distress
19.Diarrhoea
20.Constipation
21.Urinary frequency
22.Difficult urination
23.Urinary retention
24.Thickening of bronchial secretions
25.Tightness of chest
26.Wheezing
27.Nasal stuffiness
29.Allergic reactions
30.Palpitatoions
31.Tachycardia
32. Dryness of mouth,nose and throat.
Contra-indications of Dexchlorpheniramine Maleate
1.Hypersensitivity to the drug
2.Asthma
3.Lower respiratory tract diseases
4.Patients on MAO inhibitor therapy
Special Precautions while taking Dexchlorpheniramine Maleate
1. Increased intraocular pressure
2.Hyperthyroidism
3.Cardiovascular disease
4.Hypertension
5.Driving or any work requiring mental alertness
6.Avoid alcohol use
7.Along with other medication
8. Narrow angle glaucoma
9.Peptic ulcer
10.Pyloroduodenal obstruction
11.Prostatic hypertrophy
12.Bladder neck obstruction
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Neonates: Contraindicated
Indications for Dexchlorpheniramine Maleate
1. Common cold
2.Allergic symptoms
3.Sneezing
4.Itching
5.Runny nose
6.Aleergic rhinitis
7.Vasomotor rhinitis
8.Allergic conjunctivitis.
Interactions for Dexchlorpheniramine Maleate
N/A
Typical Dosage for Dexchlorpheniramine Maleate
Dosage individualized based on condition and requirement of the patient.
Adults and Children over12 years: 2 mg at every 4 to 6 hours as required.
Children 6 to 12 years: 1 mg at every 4 to 6 hours as required
Children 2 to 6 years: 0.5 mg at every 4 to 6 hours as required
Schedule of Dexchlorpheniramine Maleate
N/A
Storage Requirements for Dexchlorpheniramine Maleate
Store at room temperature at a range of 20 to 25 degree C. Protect from moisture, light and heat. Keep out of reach of children.
Effects of Missed Dosage of Dexchlorpheniramine Maleate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Dexchlorpheniramine Maleate
Provide symptomatic treatment and supportive measures. If vomiting has not occurred spontaneously the patient should be induced to vomit. This is done by having the patient drink a glass of water or milk after which the patient should be made to gag. Precautions against aspiration must be taken, especially in children. Saline cathartics, such as milk of magnesia, draw water into the bowel by osmosis and therefore, are valuable for their action in rapid dilution of bowel content. Vasopressors may be used to treat hypotension.

Home Delivery for Dexchlorpheniramine Maleate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including dexchlorpheniramine maleate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dexchlorpheniramine maleate and other medicines and health products. Home delivery services for dexchlorpheniramine maleate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dexchlorpheniramine maleate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dexchlorpheniramine maleate before they complete the sale. You can get this information while placing the order for dexchlorpheniramine maleate with the pharmacy.

Dexchlorpheniramine Maleate is a generic medicine name and there are several brands available for it. Some of the brands for dexchlorpheniramine maleate might be better known than dexchlorpheniramine maleate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dexchlorpheniramine maleate in stock, you can ask for one of the branded alternatives for dexchlorpheniramine maleate.