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- Pharmacology For Fexofenadine + Pseudoephedrine
Fexofenadine + Pseudoephedrine Pharmacology
Fexofenadine + Pseudoephedrine
About Fexofenadine + PseudoephedrineN/AMechanism of Action of Fexofenadine + PseudoephedrineN/APharmacokinets of Fexofenadine + PseudoephedrineN/AOnset of Action for Fexofenadine + PseudoephedrineN/ADuration of Action for Fexofenadine + PseudoephedrineN/AHalf Life of Fexofenadine + PseudoephedrineN/ASide Effects of Fexofenadine + PseudoephedrineN/AContra-indications of Fexofenadine + PseudoephedrineN/ASpecial Precautions while taking Fexofenadine + PseudoephedrineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Fexofenadine + PseudoephedrineN/AInteractions for Fexofenadine + PseudoephedrineN/ATypical Dosage for Fexofenadine + PseudoephedrineN/ASchedule of Fexofenadine + PseudoephedrineN/AStorage Requirements for Fexofenadine + PseudoephedrineN/AEffects of Missed Dosage of Fexofenadine + PseudoephedrineN/AEffects of Overdose of Fexofenadine + PseudoephedrineN/AFexofenadine
About FexofenadineSecond Generation H1 Antagonist, Antihistamine.Mechanism of Action of FexofenadineFexofenadine blocks one type of peripheral receptor for histamine (the H1 receptor) and thus prevents activation of H1 receptor-containing cells by histamine (Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing.) and the allergic symptoms produced by it.Pharmacokinets of FexofenadineAbsorption- Rapidly absorbed after oral administration
Distribution- Widely distributed in the body. 60-70% bound to the plasma proteins
Metabolism- Metabolized in the liver to its metabolites
Excretion- Excreted through urine (10% as unchanged), bile and feces
Onset of Action for FexofenadineN/ADuration of Action for Fexofenadine14 hrsHalf Life of Fexofenadine14.4 hrsSide Effects of Fexofenadine1. Headache
2. Dizziness
3. Drowsiness
4. Back pain
5. Cough
6. NauseaContra-indications of FexofenadineContraindicated in patients with hypersensitivity to the drug or other ingredientsSpecial Precautions while taking Fexofenadine1. Renal dysfunction
2. Any work which require mental alertness like driving and machine operationsPregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationUse with cautionIndications for Fexofenadine1. Hay fever
2. Runny nose
3. Sneezing
4. Tearing eyes
5. HivesInteractions for FexofenadineAn increase in the level of fexofenadine in plasma of 2-times was observed after co-administration of erythromycin or ketoconazole.Typical Dosage for FexofenadineOral-
Adult and children (12yrs)-
Allergic rhinitis:120mg once daily
Allergic skin conditions:180mg once daily
Schedule of FexofenadineN/AStorage Requirements for FexofenadineStore at room temperature and away from excess heat and moistureEffects of Missed Dosage of FexofenadineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of Fexofenadine Give symptomatic and supportive treatment Pseudoephedrine
About PseudoephedrineAlpha/Beta Adrenergic Agonist, a phenethylamine derivative, A nasal decongestant.Mechanism of Action of PseudoephedrineIt is a nasal decongestant with alpha-2 agonistic action. It produces local vasoconstriction, reduces blood flow, and causes shrinkage of mucosa which provides relief of nasal congestion. It reduces oedema of the nasal mucosa, thus improving ventilation, drainage and nasal stuffiness.Pharmacokinets of PseudoephedrineAbsorption: Well absorbed orally, Distribution: Widely distributed throughout the body, Metabolism: Partially metabolized in liver by N-demethylation, Excretion: Excreted through urine mainly as unchanged drug and also as metabolites.Onset of Action for Pseudoephedrine30 minutesDuration of Action for Pseudoephedrine4 to 8 hoursHalf Life of PseudoephedrineN/ASide Effects of Pseudoephedrine1. Rise in blood pressure
2. Tachycardia
3. Arrhythmias
4. CNS stimulation
5. Restlessness
6. Insomnia
7. Anxiety
8. Tremors
9. Skin rashes
10. Urinary retention
11. Respiratory difficulties
Contra-indications of Pseudoephedrine1. Hypersensitivity to the drug
2. Severe hypertension
3. Coronary artery disease
4. Patients taking monoamine oxidase inhibitors (MAOIs) or who have taken MAOIs within the previous 14 days
5. Extended release preparations are contraindicated in children below 12 yearsSpecial Precautions while taking Pseudoephedrine1. Hypertension
2. Cardiac diseases
3. Diabetes
4. Glaucoma
5. Prostatic hyperplasia
6. Hyperthyroidism
Pregnancy Related InformationUse with cautionOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationUse with cautionIndications for Pseudoephedrine1. Nasal and Eustachian tube congestion
2.Upper respiratory tract congestion
3.Adjunctive therapy in symptomatic relief of common cold, allergic rhinitis, blocked Eustachian tube, and upper respiratory tract infectionsInteractions for PseudoephedrineN/ATypical Dosage for PseudoephedrineOral:
Adults and children over 12 years: 60mg 3 to 4 times daily
Maximum dose: 240mg/day
Children (age 6 to 12): 30mg 3 to 4 times daily
Maximum dose: 120mg/day
Children (age 2 to 6): 15mg 3 to 4 times daily
Maximum dose: 60mg/day or 4mg/kg.
Schedule of PseudoephedrineN/AStorage Requirements for PseudoephedrineStore at controlled room temperature at a range of 15 to 30 degree C. Keep out of reach of childrenEffects of Missed Dosage of PseudoephedrineTake the missed dose as soon as noticed and if it is the time for next dose
Effects of Overdose of PseudoephedrineContinue the regular schedule. Do not double the dose.
Over dosage and poisoning: Provide symptomatic treatment and supportive measures. Perform emesis and gastric lavage within 4 hours of ingestion. If renal function is adequate forced diuresis will increase elimination of the drug. (Do not force diuresis in severe poisoning). Monitor and assist vital signs, cardiac state and electrolyte balance. Treat cardiac toxicity with Propranolol or other effective drugs. Treat seizures with Diazepam (I.V.) and give dilute Potassium chloride solution for hypokalaemia.
Home Delivery for Fexofenadine + Pseudoephedrine in Your City
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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fexofenadine + pseudoephedrine and other medicines and health products. Home delivery services for fexofenadine + pseudoephedrine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take fexofenadine + pseudoephedrine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fexofenadine + pseudoephedrine before they complete the sale. You can get this information while placing the order for fexofenadine + pseudoephedrine with the pharmacy.
Fexofenadine + Pseudoephedrine is a generic medicine name and there are several brands available for it. Some of the brands for fexofenadine + pseudoephedrine might be better known than fexofenadine + pseudoephedrine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fexofenadine + pseudoephedrine in stock, you can ask for one of the branded alternatives for fexofenadine + pseudoephedrine.