Entacapone Pharmacology

Entacapone

About Entacapone
COMT Inhibitor, Systemic Anti-Parkinson`s Agent.
Mechanism of Action of Entacapone
Entacapone is a peripherally acting Catechol O-methyl transferase (COMT) inhibitor. Entacapone block the O- methylation of Levodopa and increases the fraction of the drug available for delivery to the brain. This will result in increased concentration of dopamine and is useful in Parkinsonism.
Pharmacokinets of Entacapone
Absorption: Entacapone is rapidly absorbed after oral administration and the bioavailability is only 35%. Distribution: It is distributed in the body in protein bound form. Metabolism: It is extensively metabolised in the liver. Excretion: It is excreted mainly in faeces and only a small amount in urine.
Onset of Action for Entacapone
10 - 20 minutes
Duration of Action for Entacapone
2 hours
Half Life of Entacapone
3 - 5 hours
Side Effects of Entacapone
1.Nausea
2.Diarrhoea
3.Abdominal pain
4.Urine discoloration
5.Hypotension
6.Drowsiness
7.Hyperkinesia
8.Dyskinesia
9.Dizziness
10.Constipation
11.Dry mouth
12.Dyspepsia
13.Fatigue
14.Confusion
15.Fever
16.Muscle pain
Contra-indications of Entacapone
1.Hypersensitivity to Entacapone
Special Precautions while taking Entacapone
1.Renal impairment
2.Hepatic impairment
3.Patient on monoamine oxidase inhibitor therapy
4.Use caution when driving vehicle, operating machine or involving in any hazardous activities
5.Alcoholics
6.Slowly withdraw the drug with caution
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated.
NEONATES: contraindicated
Indications for Entacapone
1. Adjunct to Levodopa or Carbidopa for the treatment of idiopathic Parkinson`s disease
Interactions for Entacapone
No interaction of entacapone with carbidopa has been observed with the recommended treatment schedule. The experience of the clinical use of entacapone with several drugs, including MAO-A inhibitors, tricyclic antidepressants, noradrenaline reuptake inhibitors such as desipramine, maprotiline and venlafaxine, and medicinal products that are metabolised by COMT is limited.
Typical Dosage for Entacapone
Adult: 200 mg with Carbidopa or Levodopa
Maximum daily dose: 1600 mg / day
Schedule of Entacapone
N/A
Storage Requirements for Entacapone
Store at 15 - 30 degree C. Protect from moisture and heat. Keep out of the reach of children.
Effects of Missed Dosage of Entacapone
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Entacapone
Give supportive measures and symptomatic treatment. Gastric lavage can be done to increase the elimination of the drug. Activated charcoal is given to reduce the absorption of the drug.

Home Delivery for Entacapone in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including entacapone.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for entacapone and other medicines and health products. Home delivery services for entacapone may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take entacapone only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for entacapone before they complete the sale. You can get this information while placing the order for entacapone with the pharmacy.

Entacapone is a generic medicine name and there are several brands available for it. Some of the brands for entacapone might be better known than entacapone itself. If the pharmacy that's willing to deliver medicines to your home doesn't have entacapone in stock, you can ask for one of the branded alternatives for entacapone.