Carbidopa Pharmacology

Carbidopa

About Carbidopa

A noncompetitive DOPA decarboxylase inhibitor, Antidyskinetics, Anti-Parkinson`s Agent.

Mechanism of Action of Carbidopa

Carbidopa inhibits the peripheral decarboxylation of Levodopa and thus slowing its conversion to Dopamine in extra cerebral tissues. This results in an increased availability of Levodopa for transport to the brain and undergoes decarboxylation to Dopamine in the brain. Carbidopa increases the concentration of Levodopa in the brain.

Pharmacokinets of Carbidopa

Absorption: About 40 - 70% of the drug is absorbed after oral administration. Distribution: It is widely distributed in body tissues except the CNS. It is also distributed into breast milk. Excretion: It is excreted unchanged in urine.

Onset of Action for Carbidopa

N/A

Duration of Action for Carbidopa

N/A

Half Life of Carbidopa

1 - 2 hours

Side Effects of Carbidopa

1.Vomiting
2.Nausea
3.Anorexia
4.Aggressive behavior
5.Tardive dyskinesia
6.Ataxia
7.Tremor
8.Nervousness
9.Anxiety
10.Delirium
11.Orthostatic hypotension
12.Bitter taste
13.Hemolytic anemia
14.Agranulocytosis
15.Dry mouth

Contra-indications of Carbidopa

1.Hypersensitivity to the drug
2.Concurrent therapy with MAO inhibitors within 14days
3.Acute angle closure glaucoma
4.Melanoma

Special Precautions while taking Carbidopa

1.Severe renal impairment
2.Hepatic impairment
3.Pulmonary disorders
4.Myocardial Infarction
5.Arrhythmia
6.Peptic ulcer
7.Osychiatric illness
8.Bronchial asthma
9.Emphysema
10.Endocrine disorders

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Below 12 years:Contraindicated

Indications for Carbidopa

1.Parkinsonism

Interactions for Carbidopa

N/A

Typical Dosage for Carbidopa

Carbidopa is usually given with Levodopa.Dose is 70 - 100 mg to suppress peripheral decarboxylation of Levodopa.

Schedule of Carbidopa

Storage Requirements for Carbidopa

Store at 25 - 30 degree C in a tightly closed container.

Effects of Missed Dosage of Carbidopa

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.

Effects of Overdose of Carbidopa

Give supportive measures and symptomatic treatment.

Home Delivery for Carbidopa in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including carbidopa.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for carbidopa and other medicines and health products. Home delivery services for carbidopa may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take carbidopa only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for carbidopa before they complete the sale. You can get this information while placing the order for carbidopa with the pharmacy.

Carbidopa is a generic medicine name and there are several brands available for it. Some of the brands for carbidopa might be better known than carbidopa itself. If the pharmacy that's willing to deliver medicines to your home doesn't have carbidopa in stock, you can ask for one of the branded alternatives for carbidopa.