Piribedil Pharmacology

Piribedil

About Piribedil
A piperazine derivative,Dopamine agonist, Antiparkinsonism, Antidyskinetic.
Mechanism of Action of Piribedil
The exact mechanism of action is not known. A lesion in the Nigra striatum may be responsible for Parkinson`s disease which results in a reduction in Dopamine concentrations. This in turn causes a relative imbalance between dopaminergic and cholinergic neurological pathways. Piribedil crosses the Blood brain barrier and it act on the cerebral dopaminergic pathways. It stimulates dopaminergic receptors (D2 & D3) and restores effective neurotransmission.
Pharmacokinets of Piribedil
Absorption: Piribedil is absorbed after oral administration and the bioavailability is only 10 %. Metabolism: It is extensively metabolised in the liver.
Onset of Action for Piribedil
N/A
Duration of Action for Piribedil
N/A
Half Life of Piribedil
21 hours
Side Effects of Piribedil
1.Abdominal discomfort
2.Nausea
3.Vomiting
4.Drowsiness
5.Dizziness
6. Dyskinesia
7.Hypothermia
Contra-indications of Piribedil
1.Hypersensitivity to Piribedil
2.Acute myocardial infarction
3.Cardiovascular collapse
Special Precautions while taking Piribedil
1. Avoid concurrent use of centrally acting Dopamine antagonist
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Piribedil
1.Parkinson`s disease
2.Symptoms and signs of cerebral ageing
3.Memory and vigilance disorders
4.Disorders of intellectual function
Interactions for Piribedil
N/A
Typical Dosage for Piribedil
Parkinson`s disease
Monotherapy: 50 - 250 mg /day in divided doses with meals. Dose is depending on patient`s response,
Adjuvant therapy: 80 - 140 mg daily.
Cerebral ageing: 150 mg / day with principle meal
Schedule of Piribedil
N/A
Storage Requirements for Piribedil
Store at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children.
Effects of Missed Dosage of Piribedil
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Piribedil
Give supportive measures and symptomatic treatment.

Home Delivery for Piribedil in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including piribedil.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for piribedil and other medicines and health products. Home delivery services for piribedil may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take piribedil only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for piribedil before they complete the sale. You can get this information while placing the order for piribedil with the pharmacy.

Piribedil is a generic medicine name and there are several brands available for it. Some of the brands for piribedil might be better known than piribedil itself. If the pharmacy that's willing to deliver medicines to your home doesn't have piribedil in stock, you can ask for one of the branded alternatives for piribedil.