Bromocriptine Pharmacology
Bromocriptine
Since Dopamine is a neurotransmitter in the brain it can produces various motor, behavioural and endocrine effects.
Hormonal action: Bromocriptine inhibits synthesis and release of Prolactin from pituitary lactotrope cell by acting as a D2 agonist.
Bromocriptine increases growth hormone release in normal individual and decreases the growth hormone in patient with acromegaly.
Bromocriptine produces nausea and vomiting by stimulating dopaminergic receptors in chemoreceptor trigger zone (CTZ)
2.Nausea
3.Vomiting
4.Constipation
5.Headache
6.Dizziness
7.Skin rash
8.Dry mouth
2.Preeclampsia
2.Hepatic impairment
3.Myocardial infarction
4.Arrhythmia
5.History of psychosis
6.Peptic ulcer
7.Diabetes mellitus
8.Concurrent antihypertensive therapy.
9.Use caution when driving vehicle operating machine or activities requiring mental alertness
2.Amenorrhea and Galactorrhea associated with hyperprolactinemia
3.Acromegaly
4.Hepatic encephalopathy
5.Premenstrual syndrome
6.Cushing`s syndrome
7.Suppression of established lactation.
Phenothiazines, butyrophenones: Decreases efficacy of these drugs.
Erythromycin: increases efficacy of bromocriptine.
Alcohol: Decreases tolerance to bromocriptine and vice-versa.
Parkinson`s disease:
Initial dose: 1 - 1.25 mg at night with food for 1 week.
2 - 2.5 mg at night with food for 2nd week
5 mg / day in 2 divided doses for 3rd week
7.5 mg / day in 3 divided doses for 4th week.Then increase the dose by 2.5 mg daily every 3 - 14 days until sufficient therapeutic response is obtained
Maintenance dose: 10 - 40 mg/day.Maximum dose: 100 mg / day
Amenorrhea and Galactorrhea associated with hyperprolactinemia: Initial dose: 1.25 - 2.5 mg / day increase the dose by 2.5 mg daily every 3 - 7 days until sufficient therapeutic response is obtained.
Maintenance dose: 5 - 7.5 mg/day.Maximum dose: 40 mg / day
Acromegaly: Initial dose: 1.25 - 2.5 mg at night for 3 days increase the dose by 1.25 - 2.5 mg daily every 3 - 7 days until sufficient therapeutic response is obtained.Dose range: 20 - 30 mg / day in divided doses. Maximum dose: 100 mg / day
Hepatic encephalopathy: Initial dose: 1.25 mg / day increase the dose by 1.25 mg every 3 days until sufficient therapeutic response (15 mg) is obtained.
Premenstrual syndrome 5 -15 mg in 2 divided doses 10th day of menstrual cycle until onset of menstruation
Cushing`s syndrome: 1.25 - 2.5 mg 2 - 4 times daily
Suppression of established lactation: 2.5mg daily for 2 to 3 days. Subsequently increased to 2.5mg twice daily for two weeks.
Children: Not recommended
Home Delivery for Bromocriptine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including bromocriptine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for bromocriptine and other medicines and health products. Home delivery services for bromocriptine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take bromocriptine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for bromocriptine before they complete the sale. You can get this information while placing the order for bromocriptine with the pharmacy.
Bromocriptine is a generic medicine name and there are several brands available for it. Some of the brands for bromocriptine might be better known than bromocriptine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have bromocriptine in stock, you can ask for one of the branded alternatives for bromocriptine.