Levodopa + Carbidopa Pharmacology

Levodopa + Carbidopa

About Levodopa + Carbidopa
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Mechanism of Action of Levodopa + Carbidopa
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Pharmacokinets of Levodopa + Carbidopa
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Onset of Action for Levodopa + Carbidopa
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Duration of Action for Levodopa + Carbidopa
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Half Life of Levodopa + Carbidopa
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Side Effects of Levodopa + Carbidopa
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Contra-indications of Levodopa + Carbidopa
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Special Precautions while taking Levodopa + Carbidopa
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Pregnancy Related Information
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Old Age Related Information
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Breast Feeding Related Information
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Children Related Information
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Indications for Levodopa + Carbidopa
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Interactions for Levodopa + Carbidopa
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Typical Dosage for Levodopa + Carbidopa
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Schedule of Levodopa + Carbidopa
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Storage Requirements for Levodopa + Carbidopa
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Effects of Missed Dosage of Levodopa + Carbidopa
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Effects of Overdose of Levodopa + Carbidopa
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Levodopa

About Levodopa
Dopamine agonist, Antiparkinsonian agent.
Mechanism of Action of Levodopa
Levodopa is the precursor of Dopamine.Levodopa crosses the blood brain barrier and undergoes decarboxylation and releases Dopamine. The Dopamine stimulates dopaminergic receptors in the basal ganglia and enhances the balance between cholinergic and dopaminergic activity and results in improved modulation of voluntary nerve impulses transmitted to the motor cortex.
Pharmacokinets of Levodopa
Absorption: It is absorbed rapidly from the small intestine. Distribution: It is widely distributed in most body tissue.It crosses blood brain barrier and also distribute in the milk. Metabolism: About 95% of the drug is converted to Dopamine by l-aromatic amino acid decarboxylase enzyme.Excretion:It is excreted mainly through urine.
Onset of Action for Levodopa
N/A
Duration of Action for Levodopa
5 hour
Half Life of Levodopa
1 - 3 hours
Side Effects of Levodopa
1.Vomiting
2.Nausea
3.Anorexia
4.Aggressive behavior
5.Tardive dyskinesia
6.Ataxia
7.Tremor
8.Nervousness
9.Anxiety
10.Delirium
11.Orthostatic hypotension
12.Bitter taste
13.Hemolytic anemia
14.Agranulocytosis
Contra-indications of Levodopa
1.Hypersensitivity to the drug
2.Concurrent therapy with MAO inhibitors within 14days
3.Acute angle closure glaucoma
4.Melanoma
Special Precautions while taking Levodopa
1.Severe renal impairment
2.Hepatic impairment
3.Pulmonary disorders
4.Myocardial Infarction
5.Arrhythmia
6.Peptic ulcer
7.Osychiatric illness
8.Bronchial asthma
9.Emphysema
10.Endocrine disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Below 12 years:Contraindicated
Indications for Levodopa
1.Parkinsonism
Interactions for Levodopa
N/A
Typical Dosage for Levodopa
Initial dose: 0.5 - 1 g daily in 2 - 4 divided doses with food. Increase 100 - 750mg daily every 3 - 7 days. Maximum dose: 8 g/day
Schedule of Levodopa
H
Storage Requirements for Levodopa
Store at 25 - 30 degree C in a tightly closed container.
Effects of Missed Dosage of Levodopa
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Levodopa
Give supportive measures and symptomatic treatment.Drug can be removed from the body by gastric lavage. To reverse the toxic and therapeutic effect of Levodopa Pyridoxine 10 - 25 mg can be given.

Carbidopa

About Carbidopa
A noncompetitive DOPA decarboxylase inhibitor, Antidyskinetics, Anti-Parkinson`s Agent.
Mechanism of Action of Carbidopa
Carbidopa inhibits the peripheral decarboxylation of Levodopa and thus slowing its conversion to Dopamine in extra cerebral tissues. This results in an increased availability of Levodopa for transport to the brain and undergoes decarboxylation to Dopamine in the brain. Carbidopa increases the concentration of Levodopa in the brain.
Pharmacokinets of Carbidopa
Absorption: About 40 - 70% of the drug is absorbed after oral administration. Distribution: It is widely distributed in body tissues except the CNS. It is also distributed into breast milk. Excretion: It is excreted unchanged in urine.
Onset of Action for Carbidopa
N/A
Duration of Action for Carbidopa
N/A
Half Life of Carbidopa
1 - 2 hours
Side Effects of Carbidopa
1.Vomiting
2.Nausea
3.Anorexia
4.Aggressive behavior
5.Tardive dyskinesia
6.Ataxia
7.Tremor
8.Nervousness
9.Anxiety
10.Delirium
11.Orthostatic hypotension
12.Bitter taste
13.Hemolytic anemia
14.Agranulocytosis
15.Dry mouth
Contra-indications of Carbidopa
1.Hypersensitivity to the drug
2.Concurrent therapy with MAO inhibitors within 14days
3.Acute angle closure glaucoma
4.Melanoma
Special Precautions while taking Carbidopa
1.Severe renal impairment
2.Hepatic impairment
3.Pulmonary disorders
4.Myocardial Infarction
5.Arrhythmia
6.Peptic ulcer
7.Osychiatric illness
8.Bronchial asthma
9.Emphysema
10.Endocrine disorders
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Below 12 years:Contraindicated
Indications for Carbidopa
1.Parkinsonism
Interactions for Carbidopa
N/A
Typical Dosage for Carbidopa
Carbidopa is usually given with Levodopa.Dose is 70 - 100 mg to suppress peripheral decarboxylation of Levodopa.
Schedule of Carbidopa
H
Storage Requirements for Carbidopa
Store at 25 - 30 degree C in a tightly closed container.
Effects of Missed Dosage of Carbidopa
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Carbidopa
Give supportive measures and symptomatic treatment.

Home Delivery for Levodopa + Carbidopa in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for levodopa + carbidopa and other medicines and health products. Home delivery services for levodopa + carbidopa may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take levodopa + carbidopa only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for levodopa + carbidopa before they complete the sale. You can get this information while placing the order for levodopa + carbidopa with the pharmacy.

Levodopa + Carbidopa is a generic medicine name and there are several brands available for it. Some of the brands for levodopa + carbidopa might be better known than levodopa + carbidopa itself. If the pharmacy that's willing to deliver medicines to your home doesn't have levodopa + carbidopa in stock, you can ask for one of the branded alternatives for levodopa + carbidopa.