Glucagon Pharmacology

Glucagon

About Glucagon
Pancreatic hormone, Anti Hypoglycemic, Anti Hypoglycemic, Antidote,in insulin coma, Diagnostic Agent.
Mechanism of Action of Glucagon
Glucagon exerts it`s therapeutic action by acting through its own receptor and coupling Gs protein activates adenylyl cyclase and increases cyclic AMP in liver, heart, adipose tissue, and other tissues. It causes hyperglycaemia primarily by enhancing gluconeogenesis and glycogenolysis. It improves glucose supply to the injured tissue. It also increases the force and rate of cardiac contraction and also has a relaxant action on gut and inhibits gastric acid production.
Pharmacokinets of Glucagon
Absorption: It is administered parenterally
Metabolism: It is extensively degraded in the liver, kidney, plasma, and other tissues
Excretion: Metabolic products are excreted through urine.
Onset of Action for Glucagon
Rapid
Duration of Action for Glucagon
60 to 90 minutes
Half Life of Glucagon
3 to 10 minutes
Side Effects of Glucagon
1. Hypersensitivity reactions
2. Bronchospasm
3. Rashes
4. Urticaria
5. Respiratory distress
6. Hypotension
7. Nausea
8. Vomiting
9. Hypokalemia.

Contra-indications of Glucagon
1. Hypersensitivity to the drug
2. Glucagonoma
3. Insulinoma
4. Pheochromocytoma
Special Precautions while taking Glucagon
1. Monitor blood glucose levels till recovery
2. In children; safety and efficacy for diagnostic purpose haven`t been established


Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Glucagon
1. Hypoglycaemia
2. Cardiogenic shock
3. X-ray examination of gut, biliary colic, and diverticulitis
4. Diagnosis of pheochromocytoma.
Interactions for Glucagon
Oral anticoagulants : Efficacy of anticoagulants increased; bleeding possible. This occurs after several days of therapy and appears to be dose related. Adjust dose of oral anticoagulants accordingly.

Typical Dosage for Glucagon
Adults and children (weighing more than 20kg):
I.M., I.V., and S.C.: 0.5 to 1mg .May repeats the dose after 15minutes if patient fails to respond. When patient responds give supplemental carbohydrates.
Children (weighing below 20kg): 0.5mg. May repeats the dose after 15minutes if patient fails to respond. When patient responds give supplemental carbohydrates.
Schedule of Glucagon
H
Storage Requirements for Glucagon
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Glucagon
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Glucagon
Provide symptomatic treatment and supportive measures.

Home Delivery for Glucagon in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including glucagon.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for glucagon and other medicines and health products. Home delivery services for glucagon may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take glucagon only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for glucagon before they complete the sale. You can get this information while placing the order for glucagon with the pharmacy.

Glucagon is a generic medicine name and there are several brands available for it. Some of the brands for glucagon might be better known than glucagon itself. If the pharmacy that's willing to deliver medicines to your home doesn't have glucagon in stock, you can ask for one of the branded alternatives for glucagon.