Trihexyphenidyl Pharmacology

Trihexyphenidyl

About Trihexyphenidyl
Anticholinergic(antimuscarinic), Anti-Parkinson`s Agent ,synthetic antispasmodic.
Mechanism of Action of Trihexyphenidyl
Trihexyphenidyl is a synthetic Atropine substitute. It produces antiparkinsonian action by blocking the central cholinergic receptors. It inhibits cerebral cortex centers and blocks efferent impulses.
Trihexyphenidyl produces Mydriasis, increase the heart rate and spasmolytic action on smooth muscles. It decreases sweating and salivation.
Pharmacokinets of Trihexyphenidyl
Absorption: It is rapidly absorbed after oral administration.
Distribution: It crosses the blood brain barrier.
Excretion: It is excreted in urine.
Onset of Action for Trihexyphenidyl
1 hour
Duration of Action for Trihexyphenidyl
6 - 12 hours
Half Life of Trihexyphenidyl
3.7 hours
Side Effects of Trihexyphenidyl
1. Dry mouth
2. Nausea
3. Vomiting
4. Constipation
5. Abdominal cramps
6. Dizziness
7. Headache
8. Nervousness
9. Drowsiness
10. Blurred vision
11. Irritability
12. Tachycardia
13. Urinary retention
14. Mydriasis
15. Increased intraocular pressure
Contra-indications of Trihexyphenidyl
1. Hypersensitivity to Trihexyphenidyl
Special Precautions while taking Trihexyphenidyl
1. Renal impairment
2. Hepatic impairment
3. Cardiac impairment
4. Gastrointestinal obstructive disease
5. Genitourinary obstructive disease
6. Glaucoma
7. Prostatic hyperplasia
8. Slowly withdraw the drug with caution
9. Patient should be cautioned about driving a vehicle operating a machine or involving in any hazardous activities
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
NEONATES : Contraindicated
Indications for Trihexyphenidyl
1. Parkinsonism (idiopathic and drug induced Parkinsonism)
Interactions for Trihexyphenidyl
Amantadine: Increased incidence of anticholinergic side effects which disappear on reducing the dose of trihexiphenidyl.
Digoxin: Serum levels of digoxin increased when given orally as a slow dissolution tablet.
Haloperidol: Decreased Haloperidol serum concentration may result in worsening of schizophrenic symptoms; also development of tardive dyskinesia.
Levodopa: Efficacy of levodopa may be reduced.
Typical Dosage for Trihexyphenidyl
Adult:
Idiopathic Parkinsonism: initial dose: 1mg / day gradually increase the dose every 3 - 5 days up to 10 - 15 mg /day in 3 - 4 divided doses.
Post encephalitic Parkinsonism: 12 - 15 mg / day in divided doses.
Drug induced Parkinsonism: 5- 15 mg / day in divided doses
Schedule of Trihexyphenidyl
N/A
Storage Requirements for Trihexyphenidyl
Store at 15 - 30 degree C
Effects of Missed Dosage of Trihexyphenidyl
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Trihexyphenidyl
Give supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Control excitement with Diazepam (IV). Physostigmine is given to counteract the antimuscarinic effect of Trihexyphenidyl.

Home Delivery for Trihexyphenidyl in Your City

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Trihexyphenidyl is a generic medicine name and there are several brands available for it. Some of the brands for trihexyphenidyl might be better known than trihexyphenidyl itself. If the pharmacy that's willing to deliver medicines to your home doesn't have trihexyphenidyl in stock, you can ask for one of the branded alternatives for trihexyphenidyl.