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- Pharmacology For Gabapentin + Mecobalamine
Gabapentin + Mecobalamine Pharmacology
Gabapentin + Mecobalamine
About Gabapentin + MecobalamineN/AMechanism of Action of Gabapentin + MecobalamineN/APharmacokinets of Gabapentin + MecobalamineN/AOnset of Action for Gabapentin + MecobalamineN/ADuration of Action for Gabapentin + MecobalamineN/AHalf Life of Gabapentin + MecobalamineN/ASide Effects of Gabapentin + MecobalamineN/AContra-indications of Gabapentin + MecobalamineN/ASpecial Precautions while taking Gabapentin + MecobalamineN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Gabapentin + MecobalamineN/AInteractions for Gabapentin + MecobalamineN/ATypical Dosage for Gabapentin + MecobalamineN/ASchedule of Gabapentin + MecobalamineN/AStorage Requirements for Gabapentin + MecobalamineN/AEffects of Missed Dosage of Gabapentin + MecobalamineN/AEffects of Overdose of Gabapentin + MecobalamineN/AGabapentin
About GabapentinA GABA analogue, Anticonvulsant, Mood stabilizer.Mechanism of Action of GabapentinGabapentin is a GABA derivative and it bounds to lipophilic molecule. The mechanism of action of Gabapentin is not exactly known. It crosses blood brain barrier and enhances release of GABA.Pharmacokinets of GabapentinAbsorption: It is not well absorbed after oral administration. The bioavailability is not dose dependent. Distribution: Gabapentin is distributed in the body in unbound form. Drug crosses blood brain barrier. Metabolism: Gabapentin undergoes insignificant metabolism. Excretion: Drug is excreted mainly in urine.Onset of Action for GabapentinWithin few weeksDuration of Action for Gabapentin6 - 8 hoursHalf Life of Gabapentin5 -8hoursSide Effects of Gabapentin1.Dizziness
2.Somnolence
3.Tremor
4.Ataxia
5.Nausea
6.Vomiting
7.Convulsions
8.Dyspepsia
9.Headache
10.Fatigue
11.Diplopia
12.Nystagmus
13.Anorexia
14.Leukopenia
Contra-indications of Gabapentin1.Hypersensitivity to GabapentinSpecial Precautions while taking Gabapentin1.Renal impairment
2.Slowly withdraw the drug with caution
3.Use caution when driving vehicle, operating machine or performing other hazardous activities.
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with caution.Breast Feeding Related InformationUse with caution.Children Related InformationUse with caution.
NEONATES: contraindicatedIndications for Gabapentin1.Antiepileptic(Treatment of partial seizure)
2.Treatment of neuropathic pain
Interactions for GabapentinN/ATypical Dosage for GabapentinAdult: Initial dose: 300 mg / day increase the dose by 300 mg/day for next 2 days (up to 900 mg / day in 3 divided doses). Thereafter increase the dose until sufficient therapeutic response is obtained.
Maintenance dose: 900-1800mg /day in 3 divided doses
Maximum dose: 3.6 g /day
Children above 12 years: 10mg / kg / day in 3 divided doses, then gradually increase the dose until sufficient therapeutic response is obtained.
Schedule of GabapentinN/AStorage Requirements for GabapentinStore at 15 - 30 degree C. Protect from heat and moisture.Store the Gabapentin solution at refrigerator.Effects of Missed Dosage of GabapentinTake the missed dose as soon as noticed. If it the time for next dose then skips the missed dose and continue the regular schedule. Do not double the doseEffects of Overdose of GabapentinGive supportive measures and symptomatic treatment. Haemodialysis can be done if needed About N/AMechanism of Action of N/APharmacokinets of N/AOnset of Action for N/ADuration of Action for N/AHalf Life of N/ASide Effects of N/AContra-indications of N/ASpecial Precautions while taking N/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for N/AInteractions for N/ATypical Dosage for N/ASchedule of N/AStorage Requirements for N/AEffects of Missed Dosage of N/AEffects of Overdose of N/AHome Delivery for Gabapentin + Mecobalamine in Your City
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