Oxcarbazepine Pharmacology

Oxcarbazepine

About Oxcarbazepine
Carboxamide derivative,iminostilbenes, Anticonvulsant, mood stabilizing agent.
Mechanism of Action of Oxcarbazepine
Oxcarbazepine prolongs the inactivated state of voltage sensitive neuronal sodium ion channel either by increasing the efflux or by decreasing the influx of sodium ion across the cell membrane and inhibits the high frequency discharge.
It blocks the repetitive impulses that trigger seizures and it stabilizes the neuronal membrane. In addition it increases the potassium conductance and modulates the high voltage activated calcium channels. These also produce anticonvulsant effect.

Pharmacokinets of Oxcarbazepine
Absorption: Oxcarbazepine is well absorbed after oral administration.
Distribution: It is very widely distributed in the body in protein bound form.
Metabolism: It is metabolised in the liver to an active metabolite 10 monohydroxy metabolite.
Excretion: Excreted primarily in urine and very small amount in faeces.
Onset of Action for Oxcarbazepine
N/A
Duration of Action for Oxcarbazepine
N/A
Half Life of Oxcarbazepine
2 hours and the metabolite has 9 hours
Side Effects of Oxcarbazepine
1. Dizziness
2. Headache
3. Somnolence
4. Ataxia
5. Nausea
6. Vomiting
7. Abdominal pain
8. Blurred vision
9. Diplopia
10. Fatigue
11. Dyspepsia
12. Upper respiratory tract infections

Contra-indications of Oxcarbazepine
1. Hypersensitivity to Oxcarbazepine or known sensitivity to any of its compound.
Special Precautions while taking Oxcarbazepine
1. Hepatic impairment
2. Renal impairment
3. Cardiac failure
4. Cardiac conduction disorder
5. Hyponatremia
6. Slowly withdraw the drug with caution


Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Below 4 years : Contraindicated
Indications for Oxcarbazepine
1. Treatment of partial seizure
Interactions for Oxcarbazepine
Phenytoin: Oxcarbazepine with phenytoin / phenobarbitol can increase their levels by 40% / 15%.
Oral contraceptive: Efficacy of oral contraceptives, specially those containing ethinyl estradiol & levonorgestrol, can be reduced.
Calcium channel blockers: If given along with oxcarbazepine, levels of felodipine or verapamil can be reduced.

Typical Dosage for Oxcarbazepine
Adults: 600 mg / day in 2 divided doses if needed dose can be increased at every weeks
Maintenance dose: 600 - 1200 mg / day in 2 divided doses
Maximum dose: 2400 mg / day
Children: 8 - 10 mg / kg body weight / day in 2 divided doses
Maintenance dose: 30 mg / kg / day in divided doses
Maximum dose: 46 mg / kg / day
Schedule of Oxcarbazepine
N/A
Storage Requirements for Oxcarbazepine
Store at 15 - 30 degree C. Protect from light and moisture.
Effects of Missed Dosage of Oxcarbazepine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Oxcarbazepine
Give supportive measures and symptomatic treatment. Gastric lavage can be done to remove the drug from the body. To reduce the absorption of the drug activated charcoal can be given to the patient.

Home Delivery for Oxcarbazepine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including oxcarbazepine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for oxcarbazepine and other medicines and health products. Home delivery services for oxcarbazepine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take oxcarbazepine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for oxcarbazepine before they complete the sale. You can get this information while placing the order for oxcarbazepine with the pharmacy.

Oxcarbazepine is a generic medicine name and there are several brands available for it. Some of the brands for oxcarbazepine might be better known than oxcarbazepine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have oxcarbazepine in stock, you can ask for one of the branded alternatives for oxcarbazepine.