Palonosetron Pharmacology

Palonosetron

About Palonosetron
A serotonin 5-HT3 antagonist, Quinuclidine derivative, Antiemetic,antinauseant.
Mechanism of Action of Palonosetron
Palonosetron is a selective 5HT3 receptor antagonist. 5HT3 receptors are present in vagal nerve terminals and chemoreceptor trigger zone of area postrema of the brain. Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Palonosetron is a 5HT3 receptor antagonist, it is indicated for the prevention of nausea and vomiting associated in chemotherapy.
Pharmacokinets of Palonosetron
Absorption: Drug is completely absorbed after parenteral administration. Distribution: It is distributed mainly in protein bound form.Metabolism: It undergoes metabolism in the liver. Excretion: Drug and its metabolites are excreted mainly in urine.
Onset of Action for Palonosetron
N/A
Duration of Action for Palonosetron
N/A
Half Life of Palonosetron
40 hours
Side Effects of Palonosetron
1.Constipation
2.Diarrhoea
3.Headache
4.Light headedness
5.Fatigue
6.Abdominal pain
7.Insomnia
Contra-indications of Palonosetron
Hypersensitivity to Palonosetron
Special Precautions while taking Palonosetron
1.Cardiac Impairment
2.Hepatic impairment
3.Renal impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
Indications for Palonosetron
1. Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy.
Interactions for Palonosetron
N/A
Typical Dosage for Palonosetron
Adults:0.25 mg as I.V. for 30 seconds should be administered 30 minutes before the start of chemotherapy
Schedule of Palonosetron
N/A
Storage Requirements for Palonosetron
Store at room temperature. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Palonosetron
If you missed a dose and do not feel nauseated then skip the missed dose and go back regular schedule.
Effects of Overdose of Palonosetron
Give supportive measures and symptomatic treatment.

Home Delivery for Palonosetron in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including palonosetron.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for palonosetron and other medicines and health products. Home delivery services for palonosetron may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take palonosetron only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for palonosetron before they complete the sale. You can get this information while placing the order for palonosetron with the pharmacy.

Palonosetron is a generic medicine name and there are several brands available for it. Some of the brands for palonosetron might be better known than palonosetron itself. If the pharmacy that's willing to deliver medicines to your home doesn't have palonosetron in stock, you can ask for one of the branded alternatives for palonosetron.