Ondansetron + Paracetamol Pharmacology
Ondansetron + Paracetamol
Ondansetron
Cytotoxic chemotherapy is associated with release of Serotonin from Enterochromaffin cells in the small intestine. Serotonin triggers vomiting through 5HT3 vagal receptor that activates the vomiting reflex. Since Ondansetron is a 5HT3 receptor antagonist, it is indicated for the prevention of nausea and vomiting associated in chemotherapy.
Anaesthetic adjuncts: It is used preoperatively in order to reduce the post operative vomiting.
Distribution: It is distributed in protein bound form.
Metabolism: Ondansetron is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine.
2. Dizziness
3. Constipation
4. Musculoskeletal pain
5. Chills
6. Allergic reactions
7. Agitation
8. Chest pain
9. Malaise
10. Urinary retention
11. Elevation in hepatic enzymes
12. Hypotension
2. Intestinal obstruction
Below 6 months : Contraindicated
2. Post operative nausea and vomiting
Oral :
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:8 mg should be given 1 - 2 hour before chemotherapy or radiotherapy and repeat the same dose after the procedure every 12 hours for 1 - 2 days.
Post operative nausea and vomiting: 16 mg should be given 1 hour before anesthesia or soon after operation
IV Injection :
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy: 0.15 mg / kg IV infusion over 15 minutes should be given half an hour before starting treatment and repeat the same dose 4th and 8th hour after first dose or a single dose of 32 mg IV infusion over 15 minutes should be given half an hour before starting the treatment.
Post operative nausea and vomiting: 4 mg IV should be given immediately before anesthesia or soon after operation
Children :
Oral :
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:8 mg should be given 1 - 2 hour before chemotherapy or radiotherapy and repeat the same dose after the procedure every 12 hours for 1 - 2 days
Injection:
Nausea and vomiting associated with cytotoxic chemotherapy or radiotherapy:0.15 mg / kg IV infusion over 15 minutes should be given half an hour before starting treatment and repeat the same dose 4th and 8th hour after first dose
Children below 2 years: 0.1 mg / kg body weight as IV infusion
Maximum dose: 4 mg
If you missed a dose and feel nauseated then take the missed dose as soon as possible.
Paracetamol
It is more active on cyclo-oxygenase enzyme in brain. Peripherally it is a poor inhibitor of prostaglandin synthesis.
Analgesic action: Paracetamol raises the pain threshold and produces analgesic effect.
Antipyretic action: Paracetamol lowers fever by direct action on the thermoregulatory centre in the Hypothalamus and block the effects of endogenous pyrogen.
Distribution: It is distributed mostly in the body in unbound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: Excreted in the urine.
2. Abdominal distress
3. Allergic reactions
4. Rash
2. Renal impairment
3. Hypertension
NEONATES : Contraindicated
2. Acute gout
3. Migraine
Charcoal: Activated, administered immediately reduces absorption of paracetamol.
Domperidone and metochlopramide: Enhance absorption of paracetamol.
Alcohol: Chronic excessive ingestion of alcohol potentiates hepatotoxicity of paracetamol.
Zidovudine: Effects zidovudine may be decreased.
500 - 1000 mg in 3 times daily
Maximum dose: 4 g / day
For migraine: 500 mg to be taken at the first sign of migraine attack and repeated 4 - 6 hourly until suppress mild attacks.
Children:
60 mg / kg body weight /day in 4 divided doses.
Maintenance dose: 75 mg / kg orally every 4 - 6 hours for 2 - 3 days. Haemodialysis can be done in emergency conditions.
Home Delivery for Ondansetron + Paracetamol in Your City
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Ondansetron + Paracetamol is a generic medicine name and there are several brands available for it. Some of the brands for ondansetron + paracetamol might be better known than ondansetron + paracetamol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ondansetron + paracetamol in stock, you can ask for one of the branded alternatives for ondansetron + paracetamol.