- Medicine India
- Generic Medicines
- R
- Pharmacology For Risperidone + Trihexyphenidyl
Risperidone + Trihexyphenidyl Pharmacology
Risperidone + Trihexyphenidyl
About Risperidone + TrihexyphenidylN/AMechanism of Action of Risperidone + TrihexyphenidylN/APharmacokinets of Risperidone + TrihexyphenidylN/AOnset of Action for Risperidone + TrihexyphenidylN/ADuration of Action for Risperidone + TrihexyphenidylN/AHalf Life of Risperidone + TrihexyphenidylN/ASide Effects of Risperidone + TrihexyphenidylN/AContra-indications of Risperidone + TrihexyphenidylN/ASpecial Precautions while taking Risperidone + TrihexyphenidylN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Risperidone + TrihexyphenidylN/AInteractions for Risperidone + TrihexyphenidylN/ATypical Dosage for Risperidone + TrihexyphenidylN/ASchedule of Risperidone + TrihexyphenidylN/AStorage Requirements for Risperidone + TrihexyphenidylN/AEffects of Missed Dosage of Risperidone + TrihexyphenidylN/AEffects of Overdose of Risperidone + TrihexyphenidylN/ARisperidone
About RisperidoneSecond-Generation Antipsychotic, benzisoxazole derivative, Antimanic, Atypical Antipsychotic.Mechanism of Action of RisperidoneRisperidone exerts its antipsychotic activity by blocking Dopamine and Serotonin (5HT2) receptors. The drug has antagonistic action on alpha adrenergic and histaminergic receptors. These produce an increase in neurotransmitters concentration and thereby antipsychotic action.Pharmacokinets of RisperidoneAbsorption: It is well absorbed after oral administration.
Distribution: It is distributed in the body in protein bound form.
Metabolism: Risperidone is extensively metabolised in the liver.
Excretion: Risperidone and its metabolites are excreted primarily in urine. Small amount excreted in faeces.Onset of Action for Risperidone2 - 3 daysDuration of Action for Risperidone2 daysHalf Life of Risperidone20 hoursSide Effects of Risperidone1. Orthostatic hypotension
2. Dizziness
3. Insomnia
4. Somnolence
5. Agitation
6. Anxiety
7. Nausea
8. Headache
9. Rhinitis
10. Constipation
11. Dyspepsia
12. Abdominal pain
13. Hyperprolactinemia
14. Neuroleptic malignant syndrome
15. Tardive dyskinesia
Contra-indications of Risperidone1. Hypersensitivity to RisperidoneSpecial Precautions while taking Risperidone1. Renal impairment
2. Hepatic impairment
3. Tachycardia
4. Orthostatic hypotension
5. Prolonged QT interval
6. History of seizure
7. Patient exposed to extreme heat and those with concomitant systemic illness
8. Dehydration
9. Hyperglycemia
10. Alcoholics
11. Discontinue the drug if Tardive dyskinesia occurs
12. Patient should be cautioned while driving vehicle, operating machine and activities requiring mental alertness or judgment
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicated
NEONATES: ContraindicatedIndications for RisperidonePsychosesInteractions for RisperidoneLevodopa : Efficacy of levodopa and dopamine agonists reduced.
Carbamazepine : Chronic administration of carbamazepine may decrease it`s efficacy.
Clozapine : Chronic administration of clozapine may enhance it`s efficacy.
Typical Dosage for RisperidoneAdult: 2 mg / day in 2 divided doses. Dose is increased by 2mg every day up to 6 mg / day.
Maintenance dose: 4 - 6 mg / day in 2 divided doses
Schedule of RisperidoneHStorage Requirements for RisperidoneStore at 15 - 30 degree C. Protect from heat and light. Keep out of the reach of children.Effects of Missed Dosage of RisperidoneTake the missed dose as soon as noticed .If it is the time for next dose then skip the missed dose and take the next dose. Do not double the dose. Continue the regular schedule.Effects of Overdose of RisperidoneGive supportive measures and treatment. Gastric lavage can be done to remove the drug from the body. Absorption of the drug can be reduced by administration of activated charcoal with laxativeTrihexyphenidyl
About TrihexyphenidylAnticholinergic(antimuscarinic), Anti-Parkinson`s Agent ,synthetic antispasmodic.Mechanism of Action of TrihexyphenidylTrihexyphenidyl is a synthetic Atropine substitute. It produces antiparkinsonian action by blocking the central cholinergic receptors. It inhibits cerebral cortex centers and blocks efferent impulses.
Trihexyphenidyl produces Mydriasis, increase the heart rate and spasmolytic action on smooth muscles. It decreases sweating and salivation.
Pharmacokinets of TrihexyphenidylAbsorption: It is rapidly absorbed after oral administration.
Distribution: It crosses the blood brain barrier.
Excretion: It is excreted in urine.
Onset of Action for Trihexyphenidyl1 hourDuration of Action for Trihexyphenidyl6 - 12 hoursHalf Life of Trihexyphenidyl3.7 hoursSide Effects of Trihexyphenidyl1. Dry mouth
2. Nausea
3. Vomiting
4. Constipation
5. Abdominal cramps
6. Dizziness
7. Headache
8. Nervousness
9. Drowsiness
10. Blurred vision
11. Irritability
12. Tachycardia
13. Urinary retention
14. Mydriasis
15. Increased intraocular pressure
Contra-indications of Trihexyphenidyl1. Hypersensitivity to TrihexyphenidylSpecial Precautions while taking Trihexyphenidyl1. Renal impairment
2. Hepatic impairment
3. Cardiac impairment
4. Gastrointestinal obstructive disease
5. Genitourinary obstructive disease
6. Glaucoma
7. Prostatic hyperplasia
8. Slowly withdraw the drug with caution
9. Patient should be cautioned about driving a vehicle operating a machine or involving in any hazardous activities
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicated
NEONATES : Contraindicated
Indications for Trihexyphenidyl1. Parkinsonism (idiopathic and drug induced Parkinsonism)Interactions for TrihexyphenidylAmantadine: Increased incidence of anticholinergic side effects which disappear on reducing the dose of trihexiphenidyl.
Digoxin: Serum levels of digoxin increased when given orally as a slow dissolution tablet.
Haloperidol: Decreased Haloperidol serum concentration may result in worsening of schizophrenic symptoms; also development of tardive dyskinesia.
Levodopa: Efficacy of levodopa may be reduced.Typical Dosage for TrihexyphenidylAdult:
Idiopathic Parkinsonism: initial dose: 1mg / day gradually increase the dose every 3 - 5 days up to 10 - 15 mg /day in 3 - 4 divided doses.
Post encephalitic Parkinsonism: 12 - 15 mg / day in divided doses.
Drug induced Parkinsonism: 5- 15 mg / day in divided doses
Schedule of TrihexyphenidylN/AStorage Requirements for TrihexyphenidylStore at 15 - 30 degree CEffects of Missed Dosage of TrihexyphenidylTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of TrihexyphenidylGive supportive measures and symptomatic treatment. Drug can be removed from the body by gastric lavage or inducing emesis. Absorption of the drug can be reduced by administration of activated charcoal. Control excitement with Diazepam (IV). Physostigmine is given to counteract the antimuscarinic effect of Trihexyphenidyl. Home Delivery for Risperidone + Trihexyphenidyl in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including risperidone + trihexyphenidyl.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for risperidone + trihexyphenidyl and other medicines and health products. Home delivery services for risperidone + trihexyphenidyl may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take risperidone + trihexyphenidyl only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for risperidone + trihexyphenidyl before they complete the sale. You can get this information while placing the order for risperidone + trihexyphenidyl with the pharmacy.
Risperidone + Trihexyphenidyl is a generic medicine name and there are several brands available for it. Some of the brands for risperidone + trihexyphenidyl might be better known than risperidone + trihexyphenidyl itself. If the pharmacy that's willing to deliver medicines to your home doesn't have risperidone + trihexyphenidyl in stock, you can ask for one of the branded alternatives for risperidone + trihexyphenidyl.