Aripiprazole Pharmacology

Aripiprazole

About Aripiprazole

Second-Generation Atypical Antipsychotic, dopamine-serotonin stabilizer.

Mechanism of Action of Aripiprazole

The mechanism of action of Aripiprazole in the treatment of schizophrenia and bipolar disorder is unknown. The proposed mechanism is that Aripiprazole acts by combination of partial agonist activity at Dopamine (D2) and Serotonin (5HT1A) receptor and a potent antagonist at 5HT2A receptor.
Aripiprazole also has an antagonist activity at alpha1 adrenergic receptors.

Pharmacokinets of Aripiprazole

Absorption: Aripiprazole is well absorbed after oral administration. Distribution: Aripiprazole is extensively distributed in the body in protein bound form. Metabolism: It undergoes metabolism in the liver by hepatic enzymes. Excretion: Excreted mainly in faeces and small amount in urine also

Onset of Action for Aripiprazole

N/A

Duration of Action for Aripiprazole

N/A

Half Life of Aripiprazole

N/A

Side Effects of Aripiprazole

1.Agitation
2.Anxiety
3.Insomnia
4.Somnolence
5.Dyspepsia
6.Nausea
7.Constipation
8.Headache
9.Rash
10.Akathisia
11.Vomiting
12.Lightheadedness
13.Myalgia
14.Pharyngitis
15.Blurred vision
16.Orthostatic hypotension
17.Dry mouth

Contra-indications of Aripiprazole

1. Hypersensitivity to Aripiprazole

Special Precautions while taking Aripiprazole

1.Renal impairment,
2.Hepatic impairment,
3.Hypotension,
4.Myocardial infarction,
5.Ischemic heart disease,
6.Heart failure,
7.Dehydration,
8.Patient with history of seizure or condition that lower the seizure threshold
9.Aspiration pneumonia
10.Patient should be cautioned about operating hazardous machinery
11.Alcoholics,
12.Alzheimer`s disease and dementia

Pregnancy Related Information

Use with caution

Old Age Related Information

Use with caution

Breast Feeding Related Information

Use with caution

Children Related Information

contraindicated

Indications for Aripiprazole

1.Schizophrenia
2.Bipolar disorder

Interactions for Aripiprazole

Carbamazepine: It cause an increase in Aripiprazole clearance and lower blood levels
Ketoconazole, Quinidine, Fluoxetine, Paroxetine: They inhibt Aripirazole elimination and cause increased blood levels.

Typical Dosage for Aripiprazole

Adult:
Schizophrenia: 10 - 15 mg once daily .If needed dose can be increased after 2 weeks.
Bipolar disorder: 30 mg / day

Schedule of Aripiprazole

Storage Requirements for Aripiprazole

Store ithe drug at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children

Effects of Missed Dosage of Aripiprazole

Take the missed dose as soon as noticed. If it is the time for next dose then skip the missed dose and continue the regular schedule. Do not double the dose.

Effects of Overdose of Aripiprazole

Give supportive measures and symptomatic treatment. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Aripiprazole in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including aripiprazole.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for aripiprazole and other medicines and health products. Home delivery services for aripiprazole may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take aripiprazole only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for aripiprazole before they complete the sale. You can get this information while placing the order for aripiprazole with the pharmacy.

Aripiprazole is a generic medicine name and there are several brands available for it. Some of the brands for aripiprazole might be better known than aripiprazole itself. If the pharmacy that's willing to deliver medicines to your home doesn't have aripiprazole in stock, you can ask for one of the branded alternatives for aripiprazole.