Quetiapine Fumarate Pharmacology

Quetiapine Fumarate

About Quetiapine Fumarate
Dibenzothiazepine derivative Second-Generation Antipsychotic, Atypical Antipsychotic, Hypnotic,Sedative.
Mechanism of Action of Quetiapine Fumarate
Quetiapine fumarate exerts its antipsychotic action by inhibiting the Dopamine (D1 & D2) receptor and Serotonin (5HTIA & 5HT2) receptors. It also possesses weak antiadrenergic and antihistaminic actions.
Pharmacokinets of Quetiapine Fumarate
Absorption: Quetiapine fumarate is rapidly absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: Quetiapine fumarate extensively undergoes metabolism in the liver. Excretion: Excreted primarily in urine and small amount in faeces.
Onset of Action for Quetiapine Fumarate
1- 2 weeks
Duration of Action for Quetiapine Fumarate
N/A
Half Life of Quetiapine Fumarate
6 hours
Side Effects of Quetiapine Fumarate
1. Headache
2. Dizziness
3. Somnolence
4. Dry mouth
5. Constipation
6. Weight gain
7. Tachycardia
8. Anorexia
9. Asthenia
10. Tremor
11. Agitation
12. Hypotension
13. Abdominal pain
14. Back pain
15. Leukopenia
16. Pharyngitis
17. Neuroleptic malignant syndrome

Contra-indications of Quetiapine Fumarate
1. Hypersensitivity to Quetiapine fumarate
Special Precautions while taking Quetiapine Fumarate
1. Hepatic impairment
2. Ischaemic heart disease
3. Hypotension
4. Cardiac failure
5. Cerebrovascular disease
6. Stroke
7. Hypovolemia
8. Epilepsy
9. Aspiration pneumonia
10. Alcoholics
11. Debilitated patients
12. Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment

Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: Contraindicated
Indications for Quetiapine Fumarate
1. Schizophrenia
2. Bipolar mania
Interactions for Quetiapine Fumarate
Antihypertensives: increases the effect of antihypertensives.
Levodopa: Antagonizes levodopa and dopamine agonists.
Phenytoin and other enzyme inducers :Coadministration requires dose to be increased.
Ketoconazole: increases plasma concentration.
Lorazepam : Quetiapine fumarate decreases oral clearance of Lorazepam.
Typical Dosage for Quetiapine Fumarate
Adult:
Initial dose: 50 mg 2 times daily followed by 100mg increment in every day for next 3 days. Further dose adjustment is needed then increases the dose up to 750 mg with in 2 days.
Maximum dose: 800mg / day


Schedule of Quetiapine Fumarate
H
Storage Requirements for Quetiapine Fumarate
Store at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children.
Effects of Missed Dosage of Quetiapine Fumarate
Take the missed dose as soon as noticed. If it is the time to take the next dose then skip the missed dose and take that dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Quetiapine Fumarate
Give supportive measures and symptomatic treatment. To remove the drug from the body gastric lavage can be done. Absorption of the drug can be reduced from the body by activated charcoal administration. Maintain blood pressure with IV fluids and Extrapyramidal symptom with Anticholinergic agents.

Home Delivery for Quetiapine Fumarate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including quetiapine fumarate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for quetiapine fumarate and other medicines and health products. Home delivery services for quetiapine fumarate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take quetiapine fumarate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for quetiapine fumarate before they complete the sale. You can get this information while placing the order for quetiapine fumarate with the pharmacy.

Quetiapine Fumarate is a generic medicine name and there are several brands available for it. Some of the brands for quetiapine fumarate might be better known than quetiapine fumarate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have quetiapine fumarate in stock, you can ask for one of the branded alternatives for quetiapine fumarate.