Olanzapine Pharmacology

Olanzapine

About Olanzapine
Second-Generation Antipsychotic, thienobenzodiazepine derivative, Atypical antipsychotic.
Mechanism of Action of Olanzapine
Olanzapine is a selective monoaminergic antagonist. It is a potent inhibitor of Serotonin (5HT2receptor) and Dopamine receptors (D1, D2, D3&D4). It has also antimuscarinic, alpha 1 adrenergic blocking and antihistamine activity.
Pharmacokinets of Olanzapine
Absorption: Olanzapine is well absorbed after oral administration.
Distribution: It is widely distributed in the body in highly protein bound form.
Metabolism: It is extensively metabolised in the liver.
Excretion: It is excreted mainly in urine and also in faeces.
Onset of Action for Olanzapine
1 week
Duration of Action for Olanzapine
N/A
Half Life of Olanzapine
21 - 54 hours
Side Effects of Olanzapine
1. Hypotension
2. Dry mouth
3. Sedation
4. Nausea
5. Constipation
6. Weight gain
7. Somnolence
8. Agitation
9. Headache
10.Insomnia
11. Tardive dyskinesia
12. Dizziness
13. Increase in serum transaminases level
14. Increase in prolactin level
15. Rhinitis
16. Suicidal tendencies
17. Dysphagia
Contra-indications of Olanzapine
1. Hypersensitivity to Olanzapine
Special Precautions while taking Olanzapine
1. Renal impairment
2. Hepatic impairment
3. Heart disease
4. History of seizure
5. Paralytic ileus
6. Narrow angle glaucoma
7. Prostatic hypertrophy
8. Alcoholics
9. Slowly withdraw the drug with caution
10. Use caution while involving in any hazardous task
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES : Contraindicated
Indications for Olanzapine
1. Psychoses
Interactions for Olanzapine
N/A
Typical Dosage for Olanzapine
Adult:
Dose: 5- 10 mg / day. If sufficient response do not occur dose can be gradually increased by 5 mg every week to 20 mg / day
Schedule of Olanzapine
H
Storage Requirements for Olanzapine
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Olanzapine
Take the missed dose as soon as noticed. If it is the time for next dose then take that dose and skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Olanzapine
Give supportive measures and symptomatic treatment. Gastric lavage can be done to remove the drug from the body. Absorption of the drug can be reduced by administration of activated charcoal.

Home Delivery for Olanzapine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including olanzapine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for olanzapine and other medicines and health products. Home delivery services for olanzapine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take olanzapine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for olanzapine before they complete the sale. You can get this information while placing the order for olanzapine with the pharmacy.

Olanzapine is a generic medicine name and there are several brands available for it. Some of the brands for olanzapine might be better known than olanzapine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have olanzapine in stock, you can ask for one of the branded alternatives for olanzapine.