Haloperidol +Trihexyphenidyl Pharmacology
Haloperidol +Trihexyphenidyl
Haloperidol
In Tourette syndrome the mechanism of action is not known. It has many central and peripheral effects. It produces antiemetic effects and alpha and ganglion blockade and counteracts histamine and serotonin mediated activity.
Anaesthetic adjuncts: It is used as anaesthetic adjunct since it allays anxiety, smoothen induction and produce antiemetic action.
2.Extrapyramidal reactions
3.Leucopenia
4.Restlessness
5.Seizure
6.Weight gain
7.Muscle stiffness
8.Nausea
9.Blurred vision
10.Lethargy
11.Gynecomastia
12.Dystonia
13.Tremor
2.Parkinson`s disease
3.Depression
4.Comatose
2.Renal impairment
3.Cardio vascular diseases
4.Epilepsy
5.Narrow angle glaucoma
6.Parkinsonism
7.Urinary retention
8.Thyrotoxicosis
9.Slowly withdraw the drug with caution
CHILDREN below 3 years: contraindicated
2.Tourette`s syndrome
3.Hiccups
4.Severe tics
Almunium Salts: Decrease efficacy. Antacids should be given 1 hour before or 2 hours after haloperidol.
Anticholinergics: Decrease efficacy and increase the anticholinergic side effects of haloperidol.
Barbiturates: Decreases efficacy.
Barbiturate anaesthetics: Increase frequency and severity of neuromuscular excitation and hypotension.
Bromocriptine: Efficacy decreased by haloperidol.
Charcoal: Prevents absorption of haloperidol.
Epinephrine, Norepinephrine: Pressor effect decreased, peripheral vasoconstrictive effect antagonised.
Lithium: Disorientation, unconsciousness and extra-pyramidal symptoms.
Meperidine: Excessive sedation and hypotension.
TCAs: Serum concentration increased by haloperidol.
Valproic acid: Efficacy potentiated.
Propranolol: Increased plasma levels of both drugs.
MAOIs: Additive orthostatic hypotensive effect.
Lab. Tests: Pregnancy tests: False positive results.
Plasma bound iodine (PBI): Increase in PBI occurs.
Initial dose: 0.5 - 5 mg 2 or 3 times a day then dose can be gradually decreased or increased to 100 mg / day based on patient`s response.
Maintenance dose: 5 - 10 mg daily.
Anxiety: 1 mg / day in 2 divided doses
Hiccups: 4.5 mg / day in 3 divided doses
Tourette`s syndrome and severe tics: Initial dose of 0.5 to 1.5 mg three times daily and dose can be increased up to about 10 mg daily may be needed in Tourette`s syndrome.
In palliative care, haloperidol has been given in a dose of 1 to 3 mg every 8 hours by mouth for the treatment of restlessness and confusion.
Children: Initial dose: 25 - 50 mg / kg body weight / day in 2 divided doses
Maximum dose: 10 mg / day
Trihexyphenidyl
Trihexyphenidyl produces Mydriasis, increase the heart rate and spasmolytic action on smooth muscles. It decreases sweating and salivation.
Distribution: It crosses the blood brain barrier.
Excretion: It is excreted in urine.
2. Nausea
3. Vomiting
4. Constipation
5. Abdominal cramps
6. Dizziness
7. Headache
8. Nervousness
9. Drowsiness
10. Blurred vision
11. Irritability
12. Tachycardia
13. Urinary retention
14. Mydriasis
15. Increased intraocular pressure
2. Hepatic impairment
3. Cardiac impairment
4. Gastrointestinal obstructive disease
5. Genitourinary obstructive disease
6. Glaucoma
7. Prostatic hyperplasia
8. Slowly withdraw the drug with caution
9. Patient should be cautioned about driving a vehicle operating a machine or involving in any hazardous activities
NEONATES : Contraindicated
Digoxin: Serum levels of digoxin increased when given orally as a slow dissolution tablet.
Haloperidol: Decreased Haloperidol serum concentration may result in worsening of schizophrenic symptoms; also development of tardive dyskinesia.
Levodopa: Efficacy of levodopa may be reduced.
Idiopathic Parkinsonism: initial dose: 1mg / day gradually increase the dose every 3 - 5 days up to 10 - 15 mg /day in 3 - 4 divided doses.
Post encephalitic Parkinsonism: 12 - 15 mg / day in divided doses.
Drug induced Parkinsonism: 5- 15 mg / day in divided doses
Home Delivery for Haloperidol +Trihexyphenidyl in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including haloperidol +trihexyphenidyl.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for haloperidol +trihexyphenidyl and other medicines and health products. Home delivery services for haloperidol +trihexyphenidyl may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take haloperidol +trihexyphenidyl only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for haloperidol +trihexyphenidyl before they complete the sale. You can get this information while placing the order for haloperidol +trihexyphenidyl with the pharmacy.
Haloperidol +Trihexyphenidyl is a generic medicine name and there are several brands available for it. Some of the brands for haloperidol +trihexyphenidyl might be better known than haloperidol +trihexyphenidyl itself. If the pharmacy that's willing to deliver medicines to your home doesn't have haloperidol +trihexyphenidyl in stock, you can ask for one of the branded alternatives for haloperidol +trihexyphenidyl.