Atomoxetine Pharmacology

Atomoxetine

About Atomoxetine
Selective Norepinephrine Reuptake Inhibitor, Treatment of attention deficit/hyperactivity disorder (ADHD).
Mechanism of Action of Atomoxetine
Atomoxetine inhibits the presynaptic neuronal reuptake of neurotransmitter Noradrenaline in the regulation of attention, impulsivity and activity levels. This will produce an increase in the Noradrenaline level and used for the treatment of attention deficit hyperactivity disorder.
Pharmacokinets of Atomoxetine
Absorption: Atomoxetine is rapidly absorbed after oral administration and its bioavailability is about 63%. Distribution: It is distributed in the body in protein bound form. Metabolism: It is metabolised in the liver
Onset of Action for Atomoxetine
1 - 3 weeks
Duration of Action for Atomoxetine
N/A
Half Life of Atomoxetine
5 hour
Side Effects of Atomoxetine
1.Nausea
2.Vomiting
3.Abdominal discomfort
4.Decreased appetite
5.Dizziness
6.Drowsiness
7.Tiredness
8.Dry mouth
9.Headache
10.Urinary hesitance
11. Erectile dysfunction
12.Retrograde ejaculation
13.Dysmenorrhea
14.Irritability
15.Fatigue
16.Dyspepsia
17.Mood changes
18.Excessive sweating
19.Insomnia
20.Cough
Contra-indications of Atomoxetine
1.Narrow angle glaucoma
2.Patient on MAOI therapy with in 2 weeks.
Special Precautions while taking Atomoxetine
1.Liver impairment
2.Hypotention
3.Tachycardia
4.Hypertention
5.Patient at high risk of suicidal thinking
6.Urinary retention
7. Alcoholics
8. Patient on MAOI therapy (Discontinue the MAO inhibitor at least 2 weeks before Atomoxetine is started)
9. Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment

Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution
CHILDREN< 6 years: contraindicated
NEONATES: contraindicated
Indications for Atomoxetine
1.Attention deficit hyperactivity disorder.
Interactions for Atomoxetine
Monoamine Oxidase Inhibitors (MAOI) Do not take while using an MAOI or within 2 weeks of discontinuing and MAOI.
Albuterol - Albuterol (600 mcg iv over 2 hours) induced increases in heart rate and blood pressure. These effects were potentiated by atomoxetine (60 mg BID for 5 days) and were most marked after the initial coadministration of albuterol and atomoxetine
Pressor agents - Because of possible effects on blood pressure.

Typical Dosage for Atomoxetine
Adult (over 70 kg weight)
Initial dose: 40 mg / day given as single dose at morning or in 2 divided doses
(Morning and early evening).Dose can be gradually increased to 80 mg / day
Maximum dose: 100 mg / day
Children and adolescent up to 70 kg weight
Initial dose: 0.5 mg / kg / day given as single dose at morning or in 2 divided doses
(Morning and early evening).Dose can be gradually increased to 1.2 mg / kg / day
Maximum dose: 1.4 mg / kg body weight / day
Schedule of Atomoxetine
H
Storage Requirements for Atomoxetine
Store at 15 - 30 degree C. Keep out of the reach of children. Protect from direct light and heat.
Effects of Missed Dosage of Atomoxetine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose.
Effects of Overdose of Atomoxetine
Give supportive measures and treatment. Drug can be removed from the body by gastric lavage. Absorption of the drug can be reduced by administration of Charcoal

Home Delivery for Atomoxetine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including atomoxetine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for atomoxetine and other medicines and health products. Home delivery services for atomoxetine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take atomoxetine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for atomoxetine before they complete the sale. You can get this information while placing the order for atomoxetine with the pharmacy.

Atomoxetine is a generic medicine name and there are several brands available for it. Some of the brands for atomoxetine might be better known than atomoxetine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have atomoxetine in stock, you can ask for one of the branded alternatives for atomoxetine.