Imipramine + Chlordiazepoxide Pharmacology
Imipramine + Chlordiazepoxide
Imipramine
It is also useful in migraine prophylaxis. The monoamine uptake blocking property is related to migraine prophylactic activity. These are suited for patient with depression.
Distribution: It is widely distributed in the body in protein bound form.
Metabolism: Imipramine is metabolised in the liver to the active metabolite Desipramine.
Excretion: Drug is excreted mainly through urine.
2. Constipation
3. Difficulty in accommodation
4. Tachycardia
5. Difficulty in micturition
6. Impotence
7. Delayed ejaculation
8. Dizziness
9. Lethargy
10. Headache
11. Feeling of tiredness
12. Sedation
13. Tremor
14. Hyper-reflexia
15. Urticaria
16. Rash
17. Pruritis
18. Photosensitivity
19. Hypotension
20. Cardiomyopathy
21. Cholestatic jaundice
22. Edema
23. Agranulocytosis
24. Galactorrhoea
25. Gynaecomastia
26. Anorexia
2. Myocardial infarction
3. Patient on MAOI therapy
2. Hepatic impairment
3. Cardiac arrhythmia
4. Myocardial infarction
5. Tachycardia
6. Heart failure
7. Strokes
8. Angle closure glaucoma
9. History of urine retention
10. Increased intraocular pressure
11. Hyperthyroidism
12. Patient receiving thyroid medications
13. Patient at risk for suicide,
14. Slowly withdraw the drug with caution
15. Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment
Below 6 years: Contraindicated
2. Nocturnal enuresis in children above 5 years
3. Migraine prophylaxis
Barbiturates: Serum level of imipramine decreased; additive respiratory depressant effect.
Clonidine: Hypertensive crisis.
Dicoumarol: Increase in anticoagulation effects.
Disulfiram: Acute organic brain syndrome.
Fluoxetine & Haloperidol: Potentiate action of imipramine.
Levodopa: Its bioavailability is reduced, hypertensive episodes.
MAOIs, Furazolidone: Seizures, sweating, coma, hyperexcitability, hyperthermia, tachycardia, mydriasis, confusion, DIC (Disseminated Intravascular Coagulation) and death.
Oral Contraceptives and Phenothiazines : Increase plasma levels of imipramine.
Smoking : Increases metabolic biotransformation.
Alcohol : Sedative effect of alcohol potentiated.
Maximum daily dose: 300 mg
Children :
Nocturnal enuresis in children above 5 years: 25 mg/ day to be taken 1 hour before bed time. If satisfactory response does not occur then gradually increases the dose up to 75 mg / day.
Maximum dose: 5 mg / kg / day
If the missed dose is taken only at night then skip the missed dose.
Chlordiazepoxide
2.Drowsiness
3.Lethargy
4.Hallucination
5.Nausea
6.Constipation
7.Amnesia
8.Dependence
9.Pain at the site of injection
10.Confusion
11.Depression
12.Mood changes
2.Hepatic impairment
3.Myasthenia gravis
4.Respiratory disease
5.Jaundice
6.Use caution while driving vehicles, operating machines or other dangerous activities
children < 6 years: contraindicated
NEONATES- contraindicated
2.Treatment of alcohol withdrawal symptom
3. Insomnia
4. Pre and post operative apprehension
Aminophylline: Antagonizes the sedative effect.
Cimetidine, Oral contraceptives, Disulfiram, Fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol.
Valproic acid: Elimination of chlordiazepoxide decreased due to inhibition of hepatic metabolism leading to enhanced activity.
Digoxin: Increase in serum concentration of Digoxin.
Imipramine & Desipramine: Enhanced activity of these drugs.
Levodopa : Decrease in antiparkinsonism efficacy.
Morphine, Pethidine, Atropine and Magnesium trisilicate: Absorption of chlordiazepoxide is impaired.
Probenecid: May cause rapid onset or prolonged effect.
Rifampicin: Decreases efficacy.
Severe anxiety: 20 - 25 mg 3 - 4 times daily
Treatment of alcohol withdrawal symptom: 25 - 100 mg daily; Depending on the patient`s condition dose can be reduced after 2 - 3 weeks
Pre and post operative apprehension: 5 - 10 mg 3 - 4 times daily; the drug should be given one day before surgery in pre operative apprehension
Children: 5mg 3 - 4 times daily.
Home Delivery for Imipramine + Chlordiazepoxide in Your City
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Imipramine + Chlordiazepoxide is a generic medicine name and there are several brands available for it. Some of the brands for imipramine + chlordiazepoxide might be better known than imipramine + chlordiazepoxide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have imipramine + chlordiazepoxide in stock, you can ask for one of the branded alternatives for imipramine + chlordiazepoxide.