Dosulepin(Dothiepin) Pharmacology

Dosulepin(Dothiepin)

About Dosulepin(Dothiepin)
Tricyclic antidepressant , Serotonergic, anticholinergic, Antidepressant ,anxiolytic and antihistaminic.
Mechanism of Action of Dosulepin(Dothiepin)
Dothiepin acts by inhibiting the re-uptake of Noradrenaline, Dopamine and Serotonin (5 HT) in the CNS nerve terminals .This will result in an increased concentration of neurotransmitters in the synaptic cleft and produces antidepressant effect. Dothiepin also possesses anticholinergic and antihistaminic activities.
Pharmacokinets of Dosulepin(Dothiepin)
Absorption: Dothiepin is rapidly absorbed after oral administration. Distribution: It is widely distributed in the body in protein bound form. Metabolism: Dothiepin is metabolised to active metabolite in the liver. Excretion: Drug is excreted mainly through urine. Some is excreted through faeces also.
Onset of Action for Dosulepin(Dothiepin)
3 weeks
Duration of Action for Dosulepin(Dothiepin)
N/A
Half Life of Dosulepin(Dothiepin)
19 - 33 hour
Side Effects of Dosulepin(Dothiepin)
1.Dryness of mouth
2.Constipation
3.Difficulty in accommodation
4.Tachycardia
5.Difficulty in micturition
6.Impotence
7.Delayed ejaculation
8.Drowsiness
9.Lethargy
10.Headache
11.Feeling of tiredness
12.Sedation
13.Tremor
14.Hyperpyrexia
15.Urticaria
16.Rash
17.Pruritis
18.Photosensitivity
19.Hypotension
20.Cardiomyopathy
21.Cholestatic jaundice
22.Dependence
23.Agranulocytosis
24.Galactorrhoea
25.Gynaecomastia
26.Anorexia
Contra-indications of Dosulepin(Dothiepin)
1.Hypersensitivity to Dothiepin
2.Myocardial infarction
3.Epilepsy
4.Severe liver disease.
Special Precautions while taking Dosulepin(Dothiepin)
1.Renal impairment
2.Hepatic impairment
3.Cardiac arrhythmia
4.Myocardial infarction
5.Tachycardia
6.Heart failure
7.Strokes
8.Angle closure glaucoma
9.History of urine retention
10.Hyperthyroidism
11.Alcoholics
12.Slowly withdraw the drug with caution
13.Patient should be cautioned against driving vehicle, operating machine and activities requiring mental alertness or judgment
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
NEONATES: contraindicated
Indications for Dosulepin(Dothiepin)
Depression
Interactions for Dosulepin(Dothiepin)
Anticholinergics: Enhanced effect of anticholinergics may occur.
Barbiturates: Serum level of imipramine decreased; additive respiratory depressant effect.
Clonidine: Hypertensive crisis.
Dicoumarol: Increase in anticoagulation effects.
Disulfiram: Acute organic brain syndrome.
Fluoxetine & Haloperidol: Potentiate action of imipramine.
Levodopa: Its bioavailability is reduced, hypertensive episodes.
MAOIs, Furazolidone: Seizures, sweating, coma, hyperexcitability, hyperthermia, tachycardia, mydriasis, confusion, DIC. (Disseminated Intravascular Coagulation) and death.
Oral Contraceptives and Phenothiazines: Increase plasma levels of imipramine.
Smoking: Increases metabolic bio-transformation.
Alcohol: Sedative effect of alcohol potentiated.
Typical Dosage for Dosulepin(Dothiepin)
Adult: 75 mg / day in 3 divided doses or as single dose at night, dose can be gradually increased up to 150 mg / day.
Children: Not recommended
Schedule of Dosulepin(Dothiepin)
H
Storage Requirements for Dosulepin(Dothiepin)
Store in a cool place in a tightly closed container. Keep out of the reach of children.
Effects of Missed Dosage of Dosulepin(Dothiepin)
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Dosulepin(Dothiepin)
Give supportive measures and treatment. Remove the drug from the body by inducing emesis and gastric lavage. Activated charcoal can be given to reduce the absorption of the drug. Physostigmine can be given to reverse the CNS side effect of overdose. Seizure can be treated with Diazepam or Phenytoin, arrhythmia with Lidocaine, and acidosis with Sodium bicarbonate.

Home Delivery for Dosulepin(Dothiepin) in Your City

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However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for dosulepin(dothiepin) and other medicines and health products. Home delivery services for dosulepin(dothiepin) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take dosulepin(dothiepin) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for dosulepin(dothiepin) before they complete the sale. You can get this information while placing the order for dosulepin(dothiepin) with the pharmacy.

Dosulepin(Dothiepin) is a generic medicine name and there are several brands available for it. Some of the brands for dosulepin(dothiepin) might be better known than dosulepin(dothiepin) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have dosulepin(dothiepin) in stock, you can ask for one of the branded alternatives for dosulepin(dothiepin).