Hydroxyzine Pharmacology

Hydroxyzine

About Hydroxyzine
A first-generation H1 antagonist,piperazine derivative, Antihistamine, Antiemetic, Anxiolytic, Sedative-hypnotic.
Mechanism of Action of Hydroxyzine
Hydroxyzine compete with Histamine for H1receptor.It blocks the Histamine action s on the effector`s cell surface. It has sedative, Antiemetic, antimuscarinic and spasmolytic property.
Antianxiety action: Hydroxyzine produces its anxiolytic action through suppression of activity at subcortical levels.
Pharmacokinets of Hydroxyzine
Absorption: It is well absorbed after oral administration. Metabolism: It undergoes metabolism in the liver. Excretion: It is excreted mainly through urine and small amount of drug and metabolite through faeces.
Onset of Action for Hydroxyzine
15 - 30 minutes
Duration of Action for Hydroxyzine
4 - 6 hour
Half Life of Hydroxyzine
3 hour
Side Effects of Hydroxyzine
1.Dizziness
2.Drowsiness
3.Involuntary motor activity
4.Dry mouth
5.Nausea
6.Gastric disturbances
Contra-indications of Hydroxyzine
Hypersensitivity to Hydroxyzine
Special Precautions while taking Hydroxyzine
1.Renal diseases
2.Hepatic disease
3.Heart disease
4.Epilepsy
5.Narrow angle glaucoma
6.Prostatic hyperplasia
7.COPD
8.Use caution while driving or operate machines or involve any hazardous activities.
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Use with caution.
NEONATES: contraindicated.
Indications for Hydroxyzine
1.Anxiety
2.Pre and postoperative sedation
3.Urticaria
4.Dermatoses
Interactions for Hydroxyzine
CNS Depressants (Barbiturates, hypnotics, opiod analgesics): Potentiation of CNS depressant effect.
MAOIs, TCAs, Atropine: Potentiate antimuscarinic effects.
Aminoglycosides: Ototoxicity of aminoglycosides masked.
Aminophyllline, Benzyl penicillin, Chloramphenicol: Incompatible with these drugs.
Incompatibility reported with aminophylline, benzyl penicillin salts, chloramphenicol, sodium succinate, thioridazine and some soluble barbiturates.
Typical Dosage for Hydroxyzine
Adult: Anxiety: 200 - 400 mg in 4 divided dose
Urticaria and dermatoses: 25 mg at night. Dose can be increased to 75 - 100 mg/day in 3 or 4 divided doses
Children
Anxiety:
Children > 6 years: 25 mg 2 or 4 times a day
Children 6 months to 6 years: 25 mg 2 times a day
Urticaria and dermatoses:
> 6 years: 15 - 25 mg at night. Dose can be increased to 50 - 100 mg/day in divided doses
Children 6 months to 6 years: 5 - 15 mg at night. Dose can be increased to 50 mg/day in divided doses
Schedule of Hydroxyzine
H
Storage Requirements for Hydroxyzine
Store at 15 - 30 degree C in a tightly closed container. Protect from heat and light. Keep out of the reach of children.
Effects of Missed Dosage of Hydroxyzine
Take the missed dose as soon as noticed and if it is the time to take the next dose then skip the missed dose.
Effects of Overdose of Hydroxyzine
Give supportive measures and symptomatic treatment. Gastric lavage has to be done if the ingestion is recent. Hypotension can be treated with IV fluids or vasopressors like Phenylephrine or Metaraminol.

Home Delivery for Hydroxyzine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including hydroxyzine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for hydroxyzine and other medicines and health products. Home delivery services for hydroxyzine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take hydroxyzine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for hydroxyzine before they complete the sale. You can get this information while placing the order for hydroxyzine with the pharmacy.

Hydroxyzine is a generic medicine name and there are several brands available for it. Some of the brands for hydroxyzine might be better known than hydroxyzine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have hydroxyzine in stock, you can ask for one of the branded alternatives for hydroxyzine.