Clonazepam Pharmacology

Clonazepam

About Clonazepam
Benzodiazepine derivative, Anticonvulsant, antipanic, muscle relaxant.
Mechanism of Action of Clonazepam
Clonazepam binds to the BZD receptor in the CNS. The binding will facilitate GABA mediated chloride channel opening and produce hyperpolarisation. This will result in an increase in the concentration of the inhibitory neurotransmitter GABA and decreases firing rate of neuron. This in turn alters normal functions of the body. Clonazepam also blocks Pentylenetetrazol which is responsible for seizure production and therefore Clonazepam is useful in the treatment of epilepsy.
Pharmacokinets of Clonazepam
Absorption: It is well absorbed after oral administration. Distribution: It is distributed widely in the body in protein bound form. Metabolism: It is metabolised in the liver. Excretion: Most metabolites are excreted in urine
Onset of Action for Clonazepam
20 - 60 minute
Duration of Action for Clonazepam
6 - 12 hour
Half Life of Clonazepam
18 - 40 hour
Side Effects of Clonazepam
1.Sedation
2.Dullness
3.Ataxia
4.Drowsiness
5.Behavioural changes
6.Amnesia
7.Lethargy
8.Nystagmus
9.Salivary secretion
10 Constipation
11.Gastritis
12.Enuresis
13.Dysuria
14.Somnolence
15.Anorexia
Contra-indications of Clonazepam
1.Hypersensitivity to Benzodiazepines
2.Acute narrow angle glaucoma
Special Precautions while taking Clonazepam
1.Renal impairment
2.Hepatic impairment
3.Pulmonary insufficiency
4.Mixed type seizure
5.Porphyria
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
NEONATES-contraindicated
Indications for Clonazepam
1. Anticonvulsant in generalised tonic-clonic, Myoclonic, Status epilepticus and Absence seizures
2. Adjunct treatment in Schizophrenia
3. Neuralgia
4. severe anxiety
Interactions for Clonazepam
N/A
Typical Dosage for Clonazepam
Adult:
Anticonvulsant: Initial dose: 0.5 mg three times a day. The dose can be gradually increased by 0.5 - 1 mg up to 20 mg / day. Maintenance dose: 4 - 8 mg / day in 3- 4 divided doses
Adjunct treatment in Schizophrenia: 0.5 - 2 mg at bed time
Neuralgia: 2 - 4 mg / day
Children:
Anticonvulsant: Initial dose10 - 30 mcg / kg / day in 3 divided dose. The dose can be gradually increased up to 200 mcg / day.
Schedule of Clonazepam
H DRUG
Storage Requirements for Clonazepam
The drug should be kept at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children.
Effects of Missed Dosage of Clonazepam
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose
Effects of Overdose of Clonazepam
Give supportive measures and symptomatic treatment. Gastric lavage has to be done. Flumazenil can be given as antagonist. Hypotension can be treated with vasopressors.

Home Delivery for Clonazepam in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clonazepam.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clonazepam and other medicines and health products. Home delivery services for clonazepam may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clonazepam only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clonazepam before they complete the sale. You can get this information while placing the order for clonazepam with the pharmacy.

Clonazepam is a generic medicine name and there are several brands available for it. Some of the brands for clonazepam might be better known than clonazepam itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clonazepam in stock, you can ask for one of the branded alternatives for clonazepam.