Nicotinic Acid Pharmacology

Nicotinic Acid

About Nicotinic Acid
N/A
Mechanism of Action of Nicotinic Acid
Niacin refers to Nicotinic acid as well as Nicotinamide which exerts it`s action by influencing metabolic reactions. It is converted in to coenzymes Ncotinamide adenine dinucleotide (NAD) and its phosphate Ncotinamide adenine dinucleotide phosphate (NADP) involved in oxidation reduction reactions. These pyridine nucleotides act as hydrogen acceptors in the electron transport chain in tissue respiration, glycolysis, and fat synthesis. Nicotinic acid in high doses has vasodilator effects and also improves lipid profile; reduces serum cholesterol, raises HDL level, lowers VLDL, and LDL levels.
Pharmacokinets of Nicotinic Acid
Absorption: Well absorbed orally, Distribution: Widely distributed in the body, and also secreted in to breast milk, Modest amounts are stored in liver, Metabolism: Metabolized in to active metabolites in liver, Excretion: Extra drug is excreted through urine.
Onset of Action for Nicotinic Acid
N/A
Duration of Action for Nicotinic Acid
N/A
Half Life of Nicotinic Acid
N/A
Side Effects of Nicotinic Acid
1. Flushing
2. Activation of peptic ulcer
3. Nausea
4. Vomiting
5. Diarrhoea
6. Headache
7. Rashes
8. Pruritus
9. Hypotension
10. Arrhythmias
11. Hepatic impairment
Contra-indications of Nicotinic Acid
1. Hypersensitivity to the drug
2. Hepatic impairment
3. Peptic ulcer
4. Severe hypotension
5. Arterial haemorrhage
Special Precautions while taking Nicotinic Acid
1.History of liver disease
2.Gall bladder diseases
3.Gout
4.Coronary artery diseases
5.Diabetes mellitus
6.When use along with Statins reduces the dosage of Statins
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Nicotinic Acid
1. Pellagra
2. Niacin deficiency
3. Hartnup disease
4. Hyperlipidaemia (only nicotinic acid
5. Peripheral vascular diseases (only nicotinic acid)
Interactions for Nicotinic Acid
N/A
Typical Dosage for Nicotinic Acid
Oral:
Peripheral vascular diseases: 100 to 150mg three to five times daily. Alternatively 1000 to 2000g once daily at bed time.
Hyperlipidaemia: 1.5 to 6g daily in two to four divided doses with or after meals.

Schedule of Nicotinic Acid
C1
Storage Requirements for Nicotinic Acid
Store at controlled room temperature at a range of 15 to 30 degree C
Effects of Missed Dosage of Nicotinic Acid
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Nicotinic Acid
Provide supportive measures and symptomatic treatment

Home Delivery for Nicotinic Acid in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nicotinic acid.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nicotinic acid and other medicines and health products. Home delivery services for nicotinic acid may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nicotinic acid only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nicotinic acid before they complete the sale. You can get this information while placing the order for nicotinic acid with the pharmacy.

Nicotinic Acid is a generic medicine name and there are several brands available for it. Some of the brands for nicotinic acid might be better known than nicotinic acid itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nicotinic acid in stock, you can ask for one of the branded alternatives for nicotinic acid.