Fenofibrate Pharmacology

Fenofibrate

About Fenofibrate

Fibric Acid Derivative, PPARa agonist, Antilipemic agent, Antigout.

Mechanism of Action of Fenofibrate

It is prodrug which has greater LDL (low density lipoprotein) cholesterol lowering potential. It lowers circulating triglyceride levels by activating lipoprotein lipase which is a key enzyme in the degradation of VLDL (very low density lipoprotein) cholesterol. This effect is exerted through paroxisome proliferator-activated receptor alpha (PPARalpha) which enhances lipoprotein lipase synthesis and fatty acid oxidation. It also reduces hepatic triglyceride synthesis. It also reduces VLDL levels and increases HDL (high density lipoprotein) cholesterol. The increase in HDL cholesterol is partly due to transfer of surface lipid components from catabolised VLDL to HDL and also due to increased production of HDL apoproteins by liver.

Pharmacokinets of Fenofibrate

Absorption: Well absorbed orally, food increases the absorption.
Distribution: Widely distributed in a protein bound form
Metabolism: Metabolized by ester hydrolysis to active metabolite which undergoes glucuronide conjugation in liver.
Excretion: Excreted mainly through urine and a small portion is excreted through faeces.

Onset of Action for Fenofibrate

N/A

Duration of Action for Fenofibrate

N/A

Half Life of Fenofibrate

20 hours

Side Effects of Fenofibrate

1. Myalgia
2. Arthralgia
3. Hepatitis
4. Rashes
5. Headache
6. Dizziness
7. Arrhythmia
8. Photosensitivity
9. Fatigue
10. Asthenia
11. Paresthesia
12. Cough
13. Rhinitis
14. Sinusitis
15. Vaginitis
16. Allergic reactions
17. Alveolitis
18. Dyspepsia
19. Impotence
20. Myasthenia

Contra-indications of Fenofibrate

1. Hypersensitivity to the drug
2. Severe hepatic impairment
3. Severe renal impairment
4. Gall bladder disease

Special Precautions while taking Fenofibrate

1. Renal impairment; dosage adjustment is required
2. Hepatic impairment
3. Monitor lipid profile blood count and hepatic function before and periodically during therapy
4. If response is inadequate after 3 months therapy.

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated

Indications for Fenofibrate

1. Hyper lipidaemia (Type IIa, IIb, III, IV, and V) unresponsive to diet alone.

Interactions for Fenofibrate

N/A

Typical Dosage for Fenofibrate

Oral: 200mg once daily with food. Adjust the dosage based on patient`s response.

Schedule of Fenofibrate

Storage Requirements for Fenofibrate

Store at controlled room temperature at a range of 15 to 25 degree C. Protect from light and humidity.

Effects of Missed Dosage of Fenofibrate

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Fenofibrate

Drug is removed from the body by induced emesis and gastric lavage. Treatment is supportive and symptomatic.

Home Delivery for Fenofibrate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including fenofibrate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for fenofibrate and other medicines and health products. Home delivery services for fenofibrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take fenofibrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for fenofibrate before they complete the sale. You can get this information while placing the order for fenofibrate with the pharmacy.

Fenofibrate is a generic medicine name and there are several brands available for it. Some of the brands for fenofibrate might be better known than fenofibrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have fenofibrate in stock, you can ask for one of the branded alternatives for fenofibrate.