Bezafibrate Pharmacology

Bezafibrate

About Bezafibrate

Fibrate drug, pan-Peroxisome Proliferator-Activated Receptor (pan-PPAR) activator.Antilipemic agent.

Mechanism of Action of Bezafibrate

The drug lowers circulating triglyceride levels by activating lipoprotein lipase which is a key enzyme in the degradation of VLDL (very low density lipoprotein) cholesterol. This effect is exerted through paroxisome proliferator-activated receptor alpha (PPARalpha) which enhances lipoprotein lipase synthesis and fatty acid oxidation. It also reduces hepatic triglyceride synthesis. It also reduces VLDL levels and increases HDL (high density lipoprotein) cholesterol. The increase in HDL cholesterol is partly due to transfer of surface lipid components from catabolised VLDL to HDL and also due to increased production of HDL apoproteins by liver. The small dense LDL have been shifted to larger less dense particles. It is highly effective in mixed hyperlipoproteinemia (type III, IV, and V) also have some actions in hypercholesterolemia. It decreases circulating fibrinogen and glucose levels. It slows the atherosclerotic process.

Pharmacokinets of Bezafibrate

Absorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized partially by glucuronide conjugation in liver. Excretion: Excreted mainly through urine and a small portion is excreted through faeces.

Onset of Action for Bezafibrate

N/A

Duration of Action for Bezafibrate

N/A

Half Life of Bezafibrate

120minutes

Side Effects of Bezafibrate

1.Abdominal discomfort
2.Epigastric pain
3.Rash
4.Myalgia
5.Nausea
6.Vomiting
7.Diarrhoea
8.Dyspepsia
9.Acute appendicitis
10.Bile duct obstruction
11.Elevated liver enzymes
12.Headache
13.Fatigue
14.Blurred vision
15.Myositis
16.Leucopenia
17.Thrombocytopenia
18.Hypokalaemia
19.Alopecia
20.Dermatitis
21.Pruritus

Contra-indications of Bezafibrate

1.Hypersensitivity to the drug
2.Hepatic impairment
3.Renal impairment
4.Gall bladder disease
5.Nephrotic syndrome

Special Precautions while taking Bezafibrate

1.Renal diseases
2.Monitor lipid profile, blood count, and hepatic function before and periodically during therapy
3.If response is inadequate after 3 months therapy

Pregnancy Related Information

Contraindicated.

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated

Indications for Bezafibrate

1.Hyper lipidaemia(type IIa, IIb, III, IV, and V) unresponsive to diet alone
2.Hyperlipidaemia associated with Diabetes and Gout

Interactions for Bezafibrate

Anti-coagulants: Increases efficacy of anti-coagulants requiring dose of the latter to be reduced by half.
Sulfonylureas: Activity potentiated.

Typical Dosage for Bezafibrate

Oral: 800mg/day as two divided doses with food; or 600mg/day as three divided doses with meals.

Schedule of Bezafibrate

Storage Requirements for Bezafibrate

Store at controlled room temperature at a range of 15 to 25 degree C. Protect from light and humidity.

Effects of Missed Dosage of Bezafibrate

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Bezafibrate

Drug is removed from the body by induced emesis and gastric lavage. Treatment is supportive and symptomatic.

Home Delivery for Bezafibrate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including bezafibrate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for bezafibrate and other medicines and health products. Home delivery services for bezafibrate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take bezafibrate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for bezafibrate before they complete the sale. You can get this information while placing the order for bezafibrate with the pharmacy.

Bezafibrate is a generic medicine name and there are several brands available for it. Some of the brands for bezafibrate might be better known than bezafibrate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have bezafibrate in stock, you can ask for one of the branded alternatives for bezafibrate.