Cilostazol Pharmacology

Cilostazol

About Cilostazol

Selective Phosphodiesterase III Enzyme Inhibitor,quinolinone derivative, Antiplatelet Agent(Platelet Aggregation Inhibitor)

Mechanism of Action of Cilostazol

The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It inhibits enzyme phosphodiesterase III and causes an increase in cyclic AMP in platelets and blood vessels which results in inhibition of platelet aggregation and vasodilatation. It reversibly inhibits platelet aggregation induced by stimuli; such as thrombin, ADP, collagen, arachidonic acid, epinephrine, stress, etc. The drug also reduces triglyceride level increases HDL cholesterol level.

Pharmacokinets of Cilostazol

Absorption: Absorbed orally and bioavailability increases when administered along with a fatty meal. Distribution: Widely distributed in a protein bound form, Metabolism: Extensively metabolized in liver in to active metabolites. Excretion: Excreted mainly through urine as metabolites (about 74%), and a portion (about 20%) is excreted through faeces.

Onset of Action for Cilostazol

N/A

Duration of Action for Cilostazol

N/A

Half Life of Cilostazol

11 to 13 hours.

Side Effects of Cilostazol

1.Nausea
2.Flatulence
3.Abnormal stools
4.Diarrhoea
5.Dyspepsia
6.Abdominal pain
7.Headache
8.Dizziness
9.Vertigo
10.Palpitation
11.Tachycardia
12.Pharyngitis
13.Rhinitis
14.Myalgia
15.Back pain
16.Cough aggravation
17.Peripheral oedema
18.Infection.

Contra-indications of Cilostazol

1.Hypersensitivity to the drug
2.Congestive heart failure.

Special Precautions while taking Cilostazol

1.Severe Renal impairment
2.Along with other antiplatelet drugs
3.Severe heart diseases

Pregnancy Related Information

Contraindicated

Old Age Related Information

May be used

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated

Indications for Cilostazol

Intermittent claudication

Interactions for Cilostazol

Macrolides : When used concomitantly initiate therapy at half the recommended dose.
Diltiazem : Initiate therapy at half the recommended dose.
Other drugs: Cilostazol could have interaction because of effect of other drugs on its metabolism. (e.g., erythromycin, ketoconazole, omeprazole)

Typical Dosage for Cilostazol

Oral: 100mg 12th hourly; taken1/2 hour before or 2 hour after food. Reduce the dosage to 50mg 12th hourly when taking along with inhibitors of CYP3A4.

Schedule of Cilostazol

N/A

Storage Requirements for Cilostazol

Store at room temperature at a range of 15 to 30 degree C.Keep away from light and moisture.

Effects of Missed Dosage of Cilostazol

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Cilostazol

Carefully observe the patient and give supportive and symptomatic treatment.

Home Delivery for Cilostazol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including cilostazol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for cilostazol and other medicines and health products. Home delivery services for cilostazol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take cilostazol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for cilostazol before they complete the sale. You can get this information while placing the order for cilostazol with the pharmacy.

Cilostazol is a generic medicine name and there are several brands available for it. Some of the brands for cilostazol might be better known than cilostazol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have cilostazol in stock, you can ask for one of the branded alternatives for cilostazol.