Clopidogrel Pharmacology

Clopidogrel

About Clopidogrel
Thienopyridine class, Platelet Aggregation Inhibitor, Antithrombic, Anti platelet agent.
Mechanism of Action of Clopidogrel
The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It alters surface receptors in platelets and inhibits ADP induced platelet-fibrinogen and platelet-platelet binding and prevents platelet aggregation. It blocks G-protein coupled P2YAC type of inhibitory purinergic receptors which mediates adenylyl cyclase inhibition by ADP. It prolongs bleeding time.
Pharmacokinets of Clopidogrel
Absorption: About 50% of drug is absorbed orally.Distribution: Widely distributed in the body in a protein bound form.Metabolism: Metabolized in liver. Excretion: About 50% is excreted through urine and 46% is excreted through faeces as metabolites.
Onset of Action for Clopidogrel
2hours
Duration of Action for Clopidogrel
5days
Half Life of Clopidogrel
8 hours
Side Effects of Clopidogrel
1.Diarrhoea
2.Vomiting
3.Nausea
4.Abdominal pain
5.Headache
6.Tinnitus
7.Rash
8.Pruritus
9.Haemorrhage
10.Neutropenia (rare)
11.Thrombocytopenia (are)
Contra-indications of Clopidogrel
1. Hypersensitivity to the drug
2. Haemorrhagic disorders
3. Intracranial haemorrhage
4. Gastrointestinal tract ulcer
Special Precautions while taking Clopidogrel
1.Haemopoetic disorders
2.Renal impairment
3.Hepatic impairment
4.Trauma
5. Recent surgery
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Contraindicated
Indications for Clopidogrel
1. To reduce atherosclerotic events
2. Thrombotic disorders
3. Prevention of stroke
4. Prophylaxis of myocardial infarction
5. Peripheral vascular diseases
6. Coronary artery diseases.
Interactions for Clopidogrel
Asprin: Potentiates the effect of aspirin on collagen-induced platelet aggregation.
NSAIDs: Risk of increased occult gastrontestinal blood loss.
Phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin: Since clopidogrel inhibits CYP4502C9 it may interfere with the metabolism of these drugs.
Typical Dosage for Clopidogrel
Oral: 75mg/day as single dose.
Schedule of Clopidogrel
N/A
Storage Requirements for Clopidogrel
Store at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moisture
Effects of Missed Dosage of Clopidogrel
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Clopidogrel
Provide supportive treatment. Platelet transfusion reverses the effects of the drug.

Home Delivery for Clopidogrel in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including clopidogrel.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for clopidogrel and other medicines and health products. Home delivery services for clopidogrel may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take clopidogrel only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for clopidogrel before they complete the sale. You can get this information while placing the order for clopidogrel with the pharmacy.

Clopidogrel is a generic medicine name and there are several brands available for it. Some of the brands for clopidogrel might be better known than clopidogrel itself. If the pharmacy that's willing to deliver medicines to your home doesn't have clopidogrel in stock, you can ask for one of the branded alternatives for clopidogrel.