Ticlopidine Pharmacology

Ticlopidine

About Ticlopidine
Thienopyridine derivative, an adenosine diphosphate (ADP) receptor inhibitor, Antiplatelet Agent.
Mechanism of Action of Ticlopidine
The drug exerts it`s antithrombotic action by interfering with platelet aggregation. It alters surface receptors in platelets and inhibits ADP and fibrinogen induced platelet-fibrinogen and platelet-platelet binding and prevents platelet aggregation. It blocks G-protein coupled P2YAC type of inhibitory purinergic receptors which mediates adenylyl cyclase inhibition by ADP. It prolongs bleeding time.
Pharmacokinets of Ticlopidine
Absorption: It is well absorbed orally, Distribution: Widely distributed in the body in a protein bound form. Metabolism: Metabolized in liver in to active metabolite. Excretion: About 60% is excreted through urine and 23% is excreted through faeces as metabolites.
Onset of Action for Ticlopidine
N/A
Duration of Action for Ticlopidine
N/A
Half Life of Ticlopidine
Single dose: 8 to12 hours
Multiple doses: 4 to 8days
Side Effects of Ticlopidine
1. Diarrhoea,
2. Vomiting,
3. Nausea,
4. Abdominal pain,
5. Headache,
6. Tinnitus,
7. Rash,
8. Haemorrhage,
9. Neutropenia,
10. Thrombocytopenia,
11. Vasculitis,
12. Nephrotic syndrome,
13. Jaundice.
Contra-indications of Ticlopidine
1. Hypersensitivity to the drug,
2. Haemorrhagic disorders,
3. Gastrointestinal tract ulcer,
4. Intracranial haemorrhage,
5. Severe renal impairment,
6. Severe hepatic impairment.
Special Precautions while taking Ticlopidine

1. Haemopoetic disorders,
2. Renal impairment,
3. Hepatic impairment,
4. Trauma,
5. Recent surgery.
Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated.
Children Related Information
Contraindicated.
Indications for Ticlopidine
1. Thrombotic disorders,
2. Prevention of stroke,
3. Transient ischaemic attacks,
4. Intermittent claudication,
5. Unstable angina,
6. Prophylaxis of myocardial infarction,
7. Coronary artery diseases,
8. Diabetic retinopathy.
Interactions for Ticlopidine
Antacids: Absorption of ticlopidine decreased.
Cimetidine: Chronic cimetidine administration results in decreased clearance of ticlopidine.
Aspirin: Effect of aspirin on collagen induced platelet aggregation potentiated hence coadministation not recommended.
Digoxin: Digoxin levels may be slightly decreased.
Theophylline: Elimination half life of theophylline increased significantly.
Typical Dosage for Ticlopidine
Oral: 250mg 12th hourly with meals.
Schedule of Ticlopidine
N/A
Storage Requirements for Ticlopidine
Store at room temperature at a range of 15 to 30 degree C. Protect from excess heat and moisture.
Effects of Missed Dosage of Ticlopidine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Ticlopidine
Provide supportive treatment.

Home Delivery for Ticlopidine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including ticlopidine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for ticlopidine and other medicines and health products. Home delivery services for ticlopidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take ticlopidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for ticlopidine before they complete the sale. You can get this information while placing the order for ticlopidine with the pharmacy.

Ticlopidine is a generic medicine name and there are several brands available for it. Some of the brands for ticlopidine might be better known than ticlopidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have ticlopidine in stock, you can ask for one of the branded alternatives for ticlopidine.