Acenocoumarol Pharmacology

Acenocoumarol

About Acenocoumarol

Anticoagulant (blood thinner), Thromboembolic complications.

Mechanism of Action of Acenocoumarol

Mechanism of action: It exerts it`s pharmacological action by inhibiting regeneration of active hydroquinone from vitamin K and behaves as a competitive antagonist of vitamin K. Thus the drug interacts with synthesis of vitamin K derived clotting factors (factors; II, VII, IX, and X.) in a dose dependent manner and reduce their plasma levels. Vitamin K-hydroquinone is required for final step of gama-carboxylation of descarboxy forms of these factors. This carboxylation is essential for the ability of the clotting factors to bind Ca2+ and to get bound to phospholipid surfaces and ultimately involve in coagulation cascade.

Pharmacokinets of Acenocoumarol

Absorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form and crosses the placental barrier. Metabolism: Metabolized in the body in to an active metabolite.

Onset of Action for Acenocoumarol

Rapid

Duration of Action for Acenocoumarol

2 to 3 days

Half Life of Acenocoumarol

8 to 24hours

Side Effects of Acenocoumarol

1.Haemorrhage
2.Ulceration
3.Gastrointestinal disturbances
4.Nausea
5.Vomiting
6.Dermatitis
7.Hypersensitivity reactions
8.Urticaria
9.Rash
10.Reversible alopecia
11.Liver diseases
12.Pancreatitis

Contra-indications of Acenocoumarol

1.Hypersensitivity to the drug
2.Bleeding disorders
3.Ulceration of gastrointestinal tract
4.In sub acute bacterial endocarditis
5.Severe hypertension
6.Increased capillary permeability
7.Within one day of surgery or labour
8.Renal impairment
9.Hepatic impairment.

Special Precautions while taking Acenocoumarol

Use with caution in following conditions:
1.Hepatic diseases
2.Renal diseases
3.Gastrointestinal tract disorders
4.Hypertension
5.Immediately after surgery

Pregnancy Related Information

Contraindicated.

Old Age Related Information

Use with caution.

Breast Feeding Related Information

Use with Caution.

Children Related Information

Contraindicated

Indications for Acenocoumarol

1.Thromboembolism
2.Pulmonary embolism
3.Transient ischemic attack
4.Atrial fibrillation
5.Rheumatic heart disease

Interactions for Acenocoumarol

Drugs which enhance efficacy of Acenocoumarol: NSAIDs, Amiodarone, Antibacterial agents (Cotrimoxazole, Cephalosporins, Erythromycin, Quinolone antibiotics, Chloramphenicol, Doxycycline, INH, Neomycin) Cimetidine, Allopurinol, Diuretics and Oral anticoagulants.
Drugs which decrease efficacy: Bismuth bicarbonate, Rifampicin, Barbiturates, Griseofulvin, Magnesium.
Oral hypoglycemic agents: Efficacy of these enhanced.
Vit. K: Reverses effects

Typical Dosage for Acenocoumarol

Starts with 8 to12mg on 1st day. 4 to 8mg on 2nd day.
Maintenance dosage: 1 to 8mg daily.

Schedule of Acenocoumarol

Storage Requirements for Acenocoumarol

Store at room temperature in a light resistant container.

Effects of Missed Dosage of Acenocoumarol

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Acenocoumarol

In minor haemorrhage stoppage of drug is adequate as a treatment measure. In more advanced haemorrhage administration of Phytonadione (vitamin K1) is required. In severe haemorrhage administer fresh frozen plasma or blood.

Home Delivery for Acenocoumarol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including acenocoumarol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for acenocoumarol and other medicines and health products. Home delivery services for acenocoumarol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take acenocoumarol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for acenocoumarol before they complete the sale. You can get this information while placing the order for acenocoumarol with the pharmacy.

Acenocoumarol is a generic medicine name and there are several brands available for it. Some of the brands for acenocoumarol might be better known than acenocoumarol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have acenocoumarol in stock, you can ask for one of the branded alternatives for acenocoumarol.