Low Molecular Weight Heparins (LMWHs) Pharmacology

Low Molecular Weight Heparins (LMWHs)

About Low Molecular Weight Heparins (LMWHs)
Low molecular weight heparins, Anticoagulant.
Mechanism of Action of Low Molecular Weight Heparins (LMWHs)
Low molecular weight heparins selectively inhibits factor Xa with little effect on IIa. They induce conformational changes in antithrombin III. They have only little effect on activated partial thromoplastin time and clotting time and also have little antiplatelet action. It also reduces symptoms and prevents infarction in patients presenting with unstable angina.
Pharmacokinets of Low Molecular Weight Heparins (LMWHs)
Absorption: Bio availability is up to 90% after sub cutaneous administration.
Excretion: Excreted through urine.
Onset of Action for Low Molecular Weight Heparins (LMWHs)
N/A
Duration of Action for Low Molecular Weight Heparins (LMWHs)
N/A
Half Life of Low Molecular Weight Heparins (LMWHs)
4 to 6 hours
Side Effects of Low Molecular Weight Heparins (LMWHs)
1. Haemorrhage
2. Haematuria
3. Thrombocytopenia
4. Irritation
5. Pain
6. Ulceration
7. Hypersensitivity reactions
8. Urticaria
9. Rash
10. Anaphylaxis
11. Osteoporosis

Contra-indications of Low Molecular Weight Heparins (LMWHs)
1. Hypersensitivity to the drug
2. Bleeding disorders
3. Thrombocytopenia
4. Ulceration of gastrointestinal tract
5. In sub acute bacterial endocarditis
6. Severe hypertension
7. Haemorrhagic Shock

Special Precautions while taking Low Molecular Weight Heparins (LMWHs)
1. Hepatic diseases
2. Renal diseases
3. Severe hypertension
4. Gastrointestinal ulceration
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
Indications for Low Molecular Weight Heparins (LMWHs)
1. Deep vein thrombosis
2. Pulmonary embolism
3. Established vein thrombosis
4. Unstable angina
5. Prevent extracorporeal thrombosis during dialysis

Interactions for Low Molecular Weight Heparins (LMWHs)
N/A
Typical Dosage for Low Molecular Weight Heparins (LMWHs)
100units/kg twice daily subcutaneously. Adjust the dosage based on patient`s response.
Schedule of Low Molecular Weight Heparins (LMWHs)
H
Storage Requirements for Low Molecular Weight Heparins (LMWHs)
Store at controlled room temperature at a range of 15 to 30 degree C.
Effects of Missed Dosage of Low Molecular Weight Heparins (LMWHs)
The doctor should be informed immediately if a dose is missed
Effects of Overdose of Low Molecular Weight Heparins (LMWHs)
Immediately stops the drug during over dosage. In severe haemorrhage treat with Protamine sulfate. 1mg Protamine sulfate neutralizes 90 units of bovine heparin or 115 units of porcine heparin. Give Protamine slowly by I.V. injection over 3minutes. (Not more than 50mg should be given in any 10minutes). For severe bleeding blood transfusion is required.

Home Delivery for Low Molecular Weight Heparins (LMWHs) in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including low molecular weight heparins (lmwhs).

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for low molecular weight heparins (lmwhs) and other medicines and health products. Home delivery services for low molecular weight heparins (lmwhs) may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take low molecular weight heparins (lmwhs) only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for low molecular weight heparins (lmwhs) before they complete the sale. You can get this information while placing the order for low molecular weight heparins (lmwhs) with the pharmacy.

Low Molecular Weight Heparins (LMWHs) is a generic medicine name and there are several brands available for it. Some of the brands for low molecular weight heparins (lmwhs) might be better known than low molecular weight heparins (lmwhs) itself. If the pharmacy that's willing to deliver medicines to your home doesn't have low molecular weight heparins (lmwhs) in stock, you can ask for one of the branded alternatives for low molecular weight heparins (lmwhs).