Phentolamine Mesylate Pharmacology

Phentolamine Mesylate

About Phentolamine Mesylate
A reversible nonselective alpha-adrenergic antagonist, Imidazoline derivative, Peripheral vasodilator ,Antihypertensive.
Mechanism of Action of Phentolamine Mesylate
Phentolamine is a quick & short acting non selective, competitive alpha adrenergic blocker and suppresses the presser actions of circulating catecholamines. It also blocks 5HT-receptors and potassium channels & causes release of histamine from mast cells. It produces dilatation of peripheral blood vessels, decrease peripheral resistance & blood pressure. It causes dilatation and relaxation of blood vessels and improves blood flow. When injected in to penis (intra-cavernosal) it increases blood flow to penis which results in erection.
Pharmacokinets of Phentolamine Mesylate
Absorption: Poorly absorbed orally, so administered intravenously. Metabolism: A portion is metabolized inside the body. Excretion: Excreted partially through urine.
Excretion: Excreted partially through urine.
Onset of Action for Phentolamine Mesylate
N/A
Duration of Action for Phentolamine Mesylate
N/A
Half Life of Phentolamine Mesylate
19minutes
Side Effects of Phentolamine Mesylate
1.Postural hypotension
2.Tachycardia
3.Nausea
4.Vomiting
5.Diarrhoea
6.Cerebro vascular occlusion
7.Nasal congestion
8.Palpitation
9.Dizziness
10.Arrhythmias
11.Chest pain
Contra-indications of Phentolamine Mesylate
1.Hypersensitivity to the drug
2.Cardiovascular disorders such as coronary artery diseases, myocardial infarction, angina, and hypotension
Special Precautions while taking Phentolamine Mesylate
1.Cardiovascular disorders
2.Renal impairment
3.Peptic ulcer
4.Gastritis
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Use with caution
Indications for Phentolamine Mesylate
1.Phaeochromocytoma
2.Clonidine withdrawal
3.Hypertensive crisis
4.Extravasation after I.V. dopamine or nor epinephrine
5.Heart failure after acute myocardial infarction
Interactions for Phentolamine Mesylate
N/A
Typical Dosage for Phentolamine Mesylate
5mg I.V. or I.M. Repeat if required based on patient`s response.
Children: 1mg I.V. or 3mg I.M.
Hypertensive crisis: 5mg to 15mg I.V.
Extravasation after I.V. dopamine or nor epinephrine & dermal necrosis:
5 to10mg in 10ml normal saline
Children: 0.1 to 0.2mg/kg. Increased up to 10mg if required based on patient`s response.
Heart failure after acute myocardial infarction: 0.17mg to 0.4mg/minute as I.V. infusion.
Impotence in males: 0.5 to 1mg as intracavernosal injection along with 30mg papaverine injection

Schedule of Phentolamine Mesylate
H
Storage Requirements for Phentolamine Mesylate
Store at a temperature range of 2 to 8degree C. Do not freeze and protect from light. Keep out of reach of children.
Effects of Missed Dosage of Phentolamine Mesylate
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Phentolamine Mesylate
Treatment is supportive and symptomatic. Antidote used for associated hypotension is Norepinephrine.

Home Delivery for Phentolamine Mesylate in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including phentolamine mesylate.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for phentolamine mesylate and other medicines and health products. Home delivery services for phentolamine mesylate may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take phentolamine mesylate only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for phentolamine mesylate before they complete the sale. You can get this information while placing the order for phentolamine mesylate with the pharmacy.

Phentolamine Mesylate is a generic medicine name and there are several brands available for it. Some of the brands for phentolamine mesylate might be better known than phentolamine mesylate itself. If the pharmacy that's willing to deliver medicines to your home doesn't have phentolamine mesylate in stock, you can ask for one of the branded alternatives for phentolamine mesylate.