Xipamide Pharmacology

Xipamide

About Xipamide
A sulfonamide diuretic(Thiazide-like), Antiedema,Antihypertensive.
Mechanism of Action of Xipamide
It exerts thiazide like diuretic action by acting at site-3(central dilating segment of early distal tubule). It binds to Na+Cl- symporter and inhibits Na+Cl- symport at the luminal membrane. It increases natriuresis, kaliuresis and diuresis. It decreases Ca2+ excretion and increases Mg2+excretion. It also has minor carbonic anhydrase inhibitory action. The antihypertensive actions of the drug may be attributable to depletion of sodium and subsequent reduction in plasma volume and a decrease in peripheral resistance. Decrease in peripheral resistance is due to either the loss of sodium from the arteriolar wall or a direct action on the vascular bed. It is an effective drug in edema associated with congestive heart failure.
Pharmacokinets of Xipamide
N/A
Onset of Action for Xipamide
1 to 2 hours
Duration of Action for Xipamide
12 hours
Half Life of Xipamide
N/A
Side Effects of Xipamide
1. Gastrointestinal disturbances
2. Hypo kalaemia
3. Dizziness
4. Carbohydrate intolerance
5. Elevated lipid levels
6. Hyper urecaemia
7. Nocturia
8. Rarely other electrolyte imbalance
9. Ototoxicity


Contra-indications of Xipamide
1. Hyper uricaemia
2. Hyper calcaemia
3. Renal impairment
4. Hepatic impairment
5. Hypersensitivity to the drug
6. Hyper sensitivity to sulfonamides
7. Fluid and electrolyte imbalance
8. Addison`s disease
Special Precautions while taking Xipamide
1. Renal and hepatic diseases
2. Hyper urecaemia and Gout
3. Diabetes mellitus
4. Monitor and correct Fluid and electrolyte imbalance
5. Cirrhosis
6. Hyper calcaemia
7. Systemic lupus erythematosus
8. Prostatic hypertrophy
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Xipamide
1. Hypertension
2. Oedema
Interactions for Xipamide
Cholestyramine & Colestipol: decrease absorption of Xipamide.
Diazoxide: Additive action-may cause hyperglycemia, hyperuricaemia and hypotension.
Digitalis: Diuretic induced hypokalaemia may precipitate digitalis toxicity.
Lithium: Xipamide potentiates therapeutic and toxic effects by decreasing its renal excretion.
Frusemide: Synergy leading to profound diuresis and greater than predicted electrolyte loss.
Non depolarizing muscle relaxants: Diuretic induced hypokalaemia enhances efficacy.
Sulfonylureas: Efficacy decreased due to Xipamaide induced glucose intolerance.
Chlorpropamide: Hypokalaemia.
Propantheline: Bioavailability of Xipamide increased.
Metoclopramide: Bioavailability of Xipamide decreased.
NSAIDs: Natriuretic effect of Xipamide decreased.
Typical Dosage for Xipamide
Hypertension: 20mg once daily in the morning. Increased to 40mg 0nce daily if required.
Oedema: 40mg once daily. Reduced gradually; based on patient`s response up to 20mg.
Maximum dose: 80mg.

Schedule of Xipamide
G
Storage Requirements for Xipamide
Store at a cool dry place away from light and moisture; and at a temperature below 30 degree C. in a well closed container. Keep out of reach of children
Effects of Missed Dosage of Xipamide
Take the missed dose as soon as noticed and if it is the time to next dose then skip the missed dose.
Effects of Overdose of Xipamide
Treatment is supportive and symptomatic. Remove drug from the body by induced emesis and gastric lavage. Monitor and assist respiratory, cardiovascular, and renal function as indicated. Monitor and support fluid and electrolyte balance.

Home Delivery for Xipamide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including xipamide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for xipamide and other medicines and health products. Home delivery services for xipamide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take xipamide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for xipamide before they complete the sale. You can get this information while placing the order for xipamide with the pharmacy.

Xipamide is a generic medicine name and there are several brands available for it. Some of the brands for xipamide might be better known than xipamide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have xipamide in stock, you can ask for one of the branded alternatives for xipamide.