Morphine Pharmacology
Morphine
Distribution-It is widely distributed throughout body. 50% of it`s seen as bound and rest is seen unbound with plasma protein. It crosses the placental barrier.
Metabolism-It is metabolized in liver by glucoronide conjugation. Morphine 6- glucoronide is one of the active metabolite. During oral administration there is first metabolism.
Excretion- Excreted via urine and through bile.
Intra venous -5min
Intra muscular - 10-30min
Subcutaneous- 10-30min
Epidural and Intrathecal-15-60min.
In injection forms - 4 to 5 hrs
In the case of epidural and intra thecal administration - 24 hrs
2. Vomiting
3. Dry mouth
4. Constipation
5. Anorexia
6. Sedation
7. Euphoria
8. Nightmares
9. In large dose there is seizures may be seen.
10. Hypotension
11. Cardiac arrest
12. Arrythmia
13. Thrombocytopenia
14. Apnea
15. Respiratory arrest
16. Pruritis
17. Edema
18. In the case of long term use there is physical dependence
2.In patients with head injury, increased intra cranial pressure, seizures, pulmonary disease, hepatic or renal failure, Addison`s disease etc
3.It is also contraindicated in patients with hypersensitive reaction with other Opioid drugs
4.It is contraindicated in pregnancy and lactation
2. Liver
3. Kidney failure
4. Hypothyroidism
5. Unstable personalities
2. Preoperative sedation
3. Post operative analgesia
4. Adjunctive treatment of acute pulmonary Oedema.
5. Adjuncts to anesthesia
Adults -
5 to 20 mg aqueous solution given for every 4 hrs, which relieve moderate to severe pain .
For the suppression of cough 5mg oral solution given for every 4 hrs or controlled release tablet 15 to 30mg for every 12 hrs
Intra venous-
For relieving severe pain: initially 15mg as a loading dose which is followed by 0.8 to 10mg/hr continuously
For sedation and anesthesia: 8-10mg
For relieving acute pulmonary Oedema: 5-10mg at rate of 2mg/min.
Intramuscular and Sub cutaneous - 10 mg every 4 hrs.
Epidural- initially 5mg injection and then 1-2 mg if necessary.
Intra thecal - 0.2-1mg injection on a single occasion
For children -
0.05 to 0.2 mg /kg for severe pain.
For sedation 8-10mg.
For post operative analgesia 0.01-0.04mg/kg/hr by continuous I.V. infusion
Intramuscular and Sub cutaneous -
6 to 12 yrs 5-10mg
1 to 5 yrs 2.5-5mg.
1 to 12 months 200 mcg/ kg.
Home Delivery for Morphine in Your City
Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including morphine.
However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for morphine and other medicines and health products. Home delivery services for morphine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.
Please be aware that you should take morphine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for morphine before they complete the sale. You can get this information while placing the order for morphine with the pharmacy.
Morphine is a generic medicine name and there are several brands available for it. Some of the brands for morphine might be better known than morphine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have morphine in stock, you can ask for one of the branded alternatives for morphine.