Candesartan Pharmacology

Candesartan

About Candesartan

Angiotensin II Receptor Antagonist, Antihypertensive agents.

Mechanism of Action of Candesartan

It is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.

Pharmacokinets of Candesartan

Absorption: Rapidly and compleately absorbed orally, Distribution: Widely distributed in to the body in a protein bound form, Metabolism: Undergoes minor hepatic metabolism by ortho-deethylation to an inactive metabolite. Excretion: Excreted through faeces and urine.

Onset of Action for Candesartan

Within 3 to 4hours

Duration of Action for Candesartan

24 hours

Half Life of Candesartan

8 to 12hours

Side Effects of Candesartan

1.Dizziness
2.Swelling of lips face tongue
3.Headache
4.Coughing
5.Bronchitis
6.Chest pain
7.Edema
8.Nausea
9.Vomiting
10.Abdominal pain
11.Diarrhoea
12.Pharyngitis
13.Rhinitis
14.Sinusitis
15.Upper respiratory tract infections
16.Weakness
17.Myalgia
18.Fetopathic
19.Precipitate renal failure in renal artery stenosis and in insufficient renal blood flow
20.Rashes
21.Albuminuria

Contra-indications of Candesartan

Hypersensitivity to the drug.

Special Precautions while taking Candesartan

1.Renal impairment
2.Hepatic impairment
3.Heart failure
4.Aortic or mitral valve stenosis
5.Obstructive cardiomyopathy
6.Volume depleted and salt depleted individuals
7.Patient should be cautiously involve in driving or operating heavy machinery during therapy,
8.Avoid alcohol
9.Hyperkalemia
10.Use caution while taking potassium sparing diuretics

Pregnancy Related Information

Contraindicated

Old Age Related Information

Use with caution

Breast Feeding Related Information

Contraindicated

Children Related Information

Contraindicated

Indications for Candesartan

Hypertension.

Interactions for Candesartan

No significant drug interactions have been reported when candesartan cilexetil is given with other drugs such as glyburide, nifedipine, digoxin, warfarin, hydrochlorothazide and oral contraceptives in healthy volunteers.

Typical Dosage for Candesartan

Starts with 16mg once daily. Usual dose range is 8 to32mg/day as once daily or two divided doses.

Schedule of Candesartan

Storage Requirements for Candesartan

Store at room temperature at a range of 15 to 30 degree C. protects from direct heat and light and store in a tightly closed container.

Effects of Missed Dosage of Candesartan

Take the missed dose as soon as remember; If it is the time of next dose then skip the missed dose and take the regular dose

Effects of Overdose of Candesartan

Treatment is supportive and symptomatic. If hypotension occur kept patient in supine position and if required give I.V. infusion of normal saline.

Home Delivery for Candesartan in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including candesartan.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for candesartan and other medicines and health products. Home delivery services for candesartan may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take candesartan only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for candesartan before they complete the sale. You can get this information while placing the order for candesartan with the pharmacy.

Candesartan is a generic medicine name and there are several brands available for it. Some of the brands for candesartan might be better known than candesartan itself. If the pharmacy that's willing to deliver medicines to your home doesn't have candesartan in stock, you can ask for one of the branded alternatives for candesartan.