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- Pharmacology For Losartan potassium + Perindopril
Losartan potassium + Perindopril Pharmacology
Losartan potassium + Perindopril
About Losartan potassium + PerindoprilN/AMechanism of Action of Losartan potassium + PerindoprilN/APharmacokinets of Losartan potassium + PerindoprilN/AOnset of Action for Losartan potassium + PerindoprilN/ADuration of Action for Losartan potassium + PerindoprilN/AHalf Life of Losartan potassium + PerindoprilN/ASide Effects of Losartan potassium + PerindoprilN/AContra-indications of Losartan potassium + PerindoprilN/ASpecial Precautions while taking Losartan potassium + PerindoprilN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for Losartan potassium + PerindoprilN/AInteractions for Losartan potassium + PerindoprilN/ATypical Dosage for Losartan potassium + PerindoprilN/ASchedule of Losartan potassium + PerindoprilN/AStorage Requirements for Losartan potassium + PerindoprilN/AEffects of Missed Dosage of Losartan potassium + PerindoprilN/AEffects of Overdose of Losartan potassium + PerindoprilN/ALosartan Potassium
About Losartan PotassiumAn angiotensin II receptor antagonist, Antihypertensive.Mechanism of Action of Losartan PotassiumIt is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.Pharmacokinets of Losartan PotassiumAbsorption: Well absorbed orally, but bioavailability is about 33% due to first pass metabolism.
Distribution: Distributed in to the body in a protein bound form, but there is no brain penetration.
Metabolism: Metabolized in the liver in to active carboxylic acid metabolite and other metabolites.
Excretion: Excreted through faeces and urine.
Onset of Action for Losartan Potassium1 hourDuration of Action for Losartan PotassiumN/AHalf Life of Losartan Potassium2 hours
Half life of active metabolite: 6 to 9 hours
Side Effects of Losartan Potassium1. Hypotension
2. Hyperkalemia
3. Headache
4. Breathlessness
5. Chest pain
6. Sore throat
7. Infections
8. Weakness
9. Dizziness
10. Elevated liver enzyme levels
11. Myalgia
12. Fetopathic
13. Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow
14. Rashes
15. Insomnia
16. Nightmares
Contra-indications of Losartan Potassium1. Hypersensitivity to the drugSpecial Precautions while taking Losartan Potassium1.Hepatic impairment
2.Renal impairment
3.Heart failure
4.Volume depleted individuals
5.Monitor serum potassium levels and avoid use along with potassium sparing diuretics
6. Avoid driving or operating heavy machinery during therapy
7. Avoid alcohol use during therapy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Losartan Potassium1. HypertensionInteractions for Losartan PotassiumDiuretics, other antihypertensives: Potentiate the hypotensive effect of losartan.
Potassium sparing diuretics, potassium suppliments: Risk of hyperkalaemia.
NSAIDs: May blunt hypotensive effect of losartan.
Cytochrome P450 inhibitors like ketoconazole: Increase in AUC of losartan by 18 % but has no effect on its active metabolite.
Phenobarbital: Results in 20% reduction in AUC of losartan and its active metabolite.Typical Dosage for Losartan Potassium25 to 50mg once daily. Gradually increases up to 100mg once daily or as two divided doses.Schedule of Losartan PotassiumHStorage Requirements for Losartan PotassiumStore at room temperature at a range of 15 to 30 degree C. protect from moisture and store in a tightly closed container.Effects of Missed Dosage of Losartan PotassiumTake the missed dose as soon as remember; if it is the time of next dose then skip the missed dose and take the regular dose.Effects of Overdose of Losartan PotassiumTreatment is supportive and symptomatic.Perindopril
About PerindoprilA long-acting Dicarboxylate-containing ACE inhibitor, Antihypertensive.Mechanism of Action of PerindoprilIt is a prodrug and converted in to active Perindoprilat; which is a long acting angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. The drug does not compromise renal, cerebral, and coronary blood flow. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. The drug restores the reduced elastic properties of arteries and heart in hypertensive individuals. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.
Pharmacokinets of PerindoprilAbsorption: Well absorbed orally, Distribution: It is distributed in to the body, Metabolism: Metabolized in the body in to active metabolite, Perindoprilat; and other inactive metabolites Excretion: Excreted mainly through urine.Onset of Action for Perindopril60minutesDuration of Action for Perindopril24 hourHalf Life of PerindoprilN/ASide Effects of Perindopril1.Cough
2.Angioedema
3.Chest pain
4.Hyperkalemia
5.Rashes
6.Urticaria
7.Swelling of lips, mouth, nose, and larynx
8.Fetopathic in later half of pregnancy
9.Headache
10.Dizziness
11.Depression
12.Sleep disturbances
13.Diarrhoea
14.Anorexia
15.Nausea
16.Vomiting
17.Fatigue
18.Decreased haemoglobin count
19.Infections
20.Elevated liver enzymes
21.Acute renal failure is precipitated in renal artery stenosis
Contra-indications of Perindopril1.Hypersensitivity to the drug
2.Renal artery stenosis
3.Aortic stenosis
4.Coarctation of aorta
Special Precautions while taking Perindopril1.Renal impairment
2.Hepatic impairment
3.Ischaemic heart disease
4.Severe heart failure
5.Collagen vascular diseases
6.Angioedema
7.Cerebrovascular diseases
8.Lower dosage is needed for elderly
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Perindopril1.Hypertension
2.Congestive heart failure
Interactions for PerindoprilNitrates, Diuretics, Beta-blockers, Anti-depressants, Alcohol, Calcium channel blockers: Enhanced hypotensive effect.
Potassium sparing diuretics: Hyperkalaemia.
Sex hormones: Oestrogens and combined oral contraceptives antagonise hypotensive effect.Typical Dosage for PerindoprilStarts with 4mg; orally once daily. Increases the dose to 8mg once daily or in two divided doses; after one month of therapy depending on patient`s response.
Maximum dose: 16mg/day
In CHF patients starts the dosage with 2mg once daily dosage and gradually increases at 1 to2 weeks` intervals to 4mg or further increase in dose depends up on patient`s response.
Schedule of PerindoprilHStorage Requirements for PerindoprilStore at a temperature range of 15 to 30 degree C. in a well closed container and protect from light and moisture.
Effects of Missed Dosage of PerindoprilN/AEffects of Overdose of PerindoprilTreatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases haemodialysis is considered if required. Treatment includes I.V. infusion of normal saline solution to treat hypotension. Treat dehydration and maintain electrolyte balance.Home Delivery for Losartan potassium + Perindopril in Your City
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