Pethidine Pharmacology

Pethidine

About Pethidine
Synthetic opioid, 4-Phenylpiperidine derivative, Narcotic analgesic.
Mechanism of Action of Pethidine
Pethidine is a mu agonist.

Pharmacokinets of Pethidine
Absorption: It is well absorbed after oral administration
Distribution: It is widely distributed in the body and it crosses placenta
Metabolism: Pethidine undergoes metabolism in the liver.
Excretion: It is excreted mainly in the urine


Onset of Action for Pethidine
1 - 2 hours
Duration of Action for Pethidine
N/A
Half Life of Pethidine
3- 6 hours
Side Effects of Pethidine
1. Nausea
2. Vomiting
3. Dizziness
4. Respratory depression
5. Constipation
6. Urinary retention
7. Dysphoria


Contra-indications of Pethidine
1. Hypersensitivity to Pethidine
2. Patient on MAO inhibitor therapy
3. COPD
4. Coma
5. Head injury
6. Acute asthma
7. Convulsive disorder


Special Precautions while taking Pethidine
N/A
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution.

Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Pethidine
1.Analgesia
2.Preanaesthetic medication
Interactions for Pethidine
Monoamine oxidase (MAO) inhibitors: Concomitant administration of pethidine may lead to severe respiratory depression or excitation, delirium, hyperpyrexia, and convulsions.
Tricyclic antidepressants, chlorpromazine: Increases the respiratory depressant effects of pethidine.
Amphetamine: It has been reported to enhance the analgesic effects of pethidine and its congeners while counteracting sedation.

Typical Dosage for Pethidine
Parenteral
Adult:
Analgesia: 25 - 100 mg as IM injection and 25 - 50 mg as IV injection
PAM( preanaesthetic medication): 50 - 100mg as IM 1 hour before operation
Children:
Analgesia: 0.5 - 2 mg/ kg as IM
PAM (preanaesthetic medication): 1 - 2 mg / kg


Schedule of Pethidine
N/A
Storage Requirements for Pethidine
Store at 15 - 25 degree C.Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Pethidine
Do not apply
Effects of Overdose of Pethidine
Give supportive measures and symptomatic treatment. Opioid antagonist Naloxone can be given if necessary.

Home Delivery for Pethidine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including pethidine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for pethidine and other medicines and health products. Home delivery services for pethidine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take pethidine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for pethidine before they complete the sale. You can get this information while placing the order for pethidine with the pharmacy.

Pethidine is a generic medicine name and there are several brands available for it. Some of the brands for pethidine might be better known than pethidine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have pethidine in stock, you can ask for one of the branded alternatives for pethidine.