Nebivolol + S-Amlodipine Pharmacology

Nebivolol + S-Amlodipine

About Nebivolol + S-Amlodipine
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Mechanism of Action of Nebivolol + S-Amlodipine
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Pharmacokinets of Nebivolol + S-Amlodipine
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Onset of Action for Nebivolol + S-Amlodipine
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Duration of Action for Nebivolol + S-Amlodipine
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Half Life of Nebivolol + S-Amlodipine
N/A
Side Effects of Nebivolol + S-Amlodipine
N/A
Contra-indications of Nebivolol + S-Amlodipine
N/A
Special Precautions while taking Nebivolol + S-Amlodipine
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Pregnancy Related Information
N/A
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for Nebivolol + S-Amlodipine
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Interactions for Nebivolol + S-Amlodipine
N/A
Typical Dosage for Nebivolol + S-Amlodipine
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Schedule of Nebivolol + S-Amlodipine
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Storage Requirements for Nebivolol + S-Amlodipine
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Effects of Missed Dosage of Nebivolol + S-Amlodipine
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Effects of Overdose of Nebivolol + S-Amlodipine
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Nebivolol

About Nebivolol
Third generation cardio selective beta-1 receptor antagonist, Antihypertensive.
Mechanism of Action of Nebivolol
Nebivolol is a 3rd generation cardio selective beta-1 receptor antagonist which reduces vascular resistance, acutely lowers arterial blood pressure without depressing left ventricular function and exerts anti hypertensive effects. The drug causes coronary vasodilatation and improves myocardial ischaemia through nitric oxide release.
Pharmacokinets of Nebivolol
Absorption: Well absorbed orally, Distribution: It is distributed in to the body, Metabolism: It is extensively metabolized inside the body give active hydroxyl metabolite. Excretion: Excreted mainly through urine and rest of drug is excreted through faeces
Onset of Action for Nebivolol
2 to 6hours
Duration of Action for Nebivolol
N/A
Half Life of Nebivolol
24hours
Side Effects of Nebivolol
1.Dizziness
2.Headache
3.Tiredness
4.Gastrointestinal problems
5.Nausea
6.Rash
7.Fatigue
8.Vomiting
9.Diarrhoea
10.Raynaud`s syndrome
11.Paraesthesia
12.Dyspnoea
13.Oedema
Contra-indications of Nebivolol
1.Hypersensitivity to the drug
2.Uncontrolled heart failure
3.Second or third degree heart block
4.Cardiogenic shock
5.Bradycardia
6.Phaeochromocytoma
7.Hepatic impairment
8.Sick sinus syndrome
9.Chronic obstructive pulmonary disorders
10.Metabolic acidosis
11.Hypotension
12.Peripheral vascular disorders
13.Along with Verapamil
Special Precautions while taking Nebivolol
1.Cardiac insufficiency
2.First degree heart block
3.Prinzmetal angina
4.Raynaud`s syndrome
5.Renal impairment
6.The drug should be gradually withdraw with caution
7.Chronic obstructive pulmonary diseases


Pregnancy Related Information
Contraindicated.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Contraindicated.
Children Related Information
Contraindicated.
Indications for Nebivolol
1.Hypertension
Interactions for Nebivolol
N/A
Typical Dosage for Nebivolol
5mg once daily
Patients above 65years of age: Starts with 2.5mg and increases to 5mg based on patient`s response
Renal impairment: Starts with 2.5mg and increases to 5mg based on patient`s response

Schedule of Nebivolol
H
Storage Requirements for Nebivolol
Store in a dry place below 25 degree C. Keep out of reach of children

Effects of Missed Dosage of Nebivolol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Nebivolol
Treatment is supportive and symptomatic. After ingestion empty the stomach by induced emesis or gastric lavage. Administer activated charcoal to reduce absorption. Treat Bradycardia with atropine. If required administer Isoproterinol with caution; in heart block. Treat hypotension with glucagons and vasopressors like epinephrine. Treat cardiac failure with diuretics and cardiac glycosides

S-Amlodipine

About S-Amlodipine
Calcium Channel Blocker (dihydropyridine class), Anti hypertensive,anti angina.
Mechanism of Action of S-Amlodipine
S-Amlodipine, which is an enantiomer of Amlodipine; is a dihydropyridine Ca2+ channel blocker. It exerts it`s antihypertensive action through blocking the influx of Ca2+ ions through voltage gated L-type Calcium channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells and causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand and improves oxygen supply to myocardial cells. It directly dilates vascular smooth muscle and reduces hypertension.
Pharmacokinets of S-Amlodipine
N/A
Onset of Action for S-Amlodipine
N/A
Duration of Action for S-Amlodipine
N/A
Half Life of S-Amlodipine
N/A
Side Effects of S-Amlodipine
1.Headache
2.Dizziness
3.Nausea
4.Abdominal pain
5.Fatigue
6.Flushing
7.Pruritus
8.Rash
9.Dyspnea
10.Dyspepsia
11.Muscle spasm

Contra-indications of S-Amlodipine
1.Hyper sensitivity to the drug or other dihydropyridines
2.Hepatic impairment


Special Precautions while taking S-Amlodipine
Hepatic impairment
Pregnancy Related Information
Contraindicated
Old Age Related Information
N/A
Breast Feeding Related Information
N/A
Children Related Information
N/A
Indications for S-Amlodipine
Hypertension
Interactions for S-Amlodipine
N/A
Typical Dosage for S-Amlodipine
2.5mg once daily
Schedule of S-Amlodipine
H
Storage Requirements for S-Amlodipine
Store at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of S-Amlodipine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of S-Amlodipine
Give supportive measures and symptomatic treatment.

Home Delivery for Nebivolol + S-Amlodipine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nebivolol + s-amlodipine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nebivolol + s-amlodipine and other medicines and health products. Home delivery services for nebivolol + s-amlodipine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nebivolol + s-amlodipine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nebivolol + s-amlodipine before they complete the sale. You can get this information while placing the order for nebivolol + s-amlodipine with the pharmacy.

Nebivolol + S-Amlodipine is a generic medicine name and there are several brands available for it. Some of the brands for nebivolol + s-amlodipine might be better known than nebivolol + s-amlodipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nebivolol + s-amlodipine in stock, you can ask for one of the branded alternatives for nebivolol + s-amlodipine.