Lercanidipine Pharmacology

Lercanidipine

About Lercanidipine
A selective calcium channel blocker, dihydropyridine derivative, Antihypertensive.
Mechanism of Action of Lercanidipine
Lercanidipine is a vasoselective long acting dihydropyridine Ca2+ channel blocker. It exerts antihypertensive actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. It has greater effects on vascular smooth muscles than cardiac muscles. Thus causes dilatation of vascular endothelium, decrease total peripheral resistance, and decreases both systolic and diastolic BP. It possesses anti atherosclerogenic action. As a coronary vasodilator it improves coronary blood flow.
Pharmacokinets of Lercanidipine
Absorption: Well absorbed orally, bioavailability is reduced due to first pass metabolism.
Distribution: Widely distributed in a protein bound form.
Metabolism: Metabolized in liver in to inactive metabolites.
Excretion: Excreted through urine and faeces.
Onset of Action for Lercanidipine
N/A
Duration of Action for Lercanidipine
N/A
Half Life of Lercanidipine
N/A
Side Effects of Lercanidipine
1. Flushing
2. Tachycardia
3. Palpitation
4. Hypotension
5. Edema
6. Headache
7. Dizziness
8. Vertigo
9. Drowsiness
10. Fatigue
11. Asthenia
12. Gastrointestinal disturbances
13. Dyspepsia
14. Diarrhoea
15. Abdominal pain
16. Somnolence
17. Polyuria
18. Myalgia
19. Rash

Contra-indications of Lercanidipine
1. Acute myocardial infarction
2. Heart failure
3. Aortic stenosis
4. Hypersensitivity to the drug
5. Severe hepatic and renal impairment

Special Precautions while taking Lercanidipine
1.Cardiovascular disorders: Use cautiously in cardiovascular disorders such as congestive heart failure, cardiovascular insufficiency, hypotension, Ischaemic heart diseases, Left ventricular outflow obstruction, Sick sinus syndrome, Unstable angina etc.
2. Hepatic impairment
3. Renal impairment
Other precautions:
1. Slowly withdraw the drug with caution
2. Avoid alcohol use during therapy
3. Use cautiously along with other antihypertensive drugs


Pregnancy Related Information
Contraindicated
Old Age Related Information
Contraindicated
Breast Feeding Related Information
Contraindicated
Children Related Information
Contraindicated
Indications for Lercanidipine
1. Hypertension
Interactions for Lercanidipine
Avoid grapefruit juice as it may affect metabolism.
Histamine H2 antagonists: Cimetidine and ranitidine enhance the bioavailability of lercanidipine.
Beta blockers: Though advantageous in some, concomitant use results in increased adverse effects like bradycardia and conduction disturbances.
Digitalis Glycosides: Increased serum digoxin levels with possible toxicity.
Magnesium Sulphate: With parenteral magnesium suplhate neuromuscular blockade and hypotension may occur.
Theophyllines: Increased pharmacological effects of theophylline, resulting in toxicity.
Quinidine: Hypotension, bradycardia, ventricular tachycardia, AV block and pulmonary oedema may occur. Serum quinidine levels may also be decreased by lercanidipine.
Anticoagulants: Increased prothrombin time.
Fentanyl: Severe hypotension or increased fluid requirements.
Typical Dosage for Lercanidipine
10mg once daily; 15minutes before meals. Gradually increased at 2week intervals up to 20mg if required depending up on the patient`s response..
Schedule of Lercanidipine
H
Storage Requirements for Lercanidipine
Store at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of Lercanidipine
Take the missed dose as soon as remember and If it is the time for next dose then skip the missed dose and take the regular dose.
Effects of Overdose of Lercanidipine
Monitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine if required.

Home Delivery for Lercanidipine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including lercanidipine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for lercanidipine and other medicines and health products. Home delivery services for lercanidipine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take lercanidipine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for lercanidipine before they complete the sale. You can get this information while placing the order for lercanidipine with the pharmacy.

Lercanidipine is a generic medicine name and there are several brands available for it. Some of the brands for lercanidipine might be better known than lercanidipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have lercanidipine in stock, you can ask for one of the branded alternatives for lercanidipine.