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- Pharmacology For S-Amlodipine + Losartan potassium
S-Amlodipine + Losartan potassium Pharmacology
S-Amlodipine + Losartan potassium
About S-Amlodipine + Losartan potassiumN/AMechanism of Action of S-Amlodipine + Losartan potassiumN/APharmacokinets of S-Amlodipine + Losartan potassiumN/AOnset of Action for S-Amlodipine + Losartan potassiumN/ADuration of Action for S-Amlodipine + Losartan potassiumN/AHalf Life of S-Amlodipine + Losartan potassiumN/ASide Effects of S-Amlodipine + Losartan potassiumN/AContra-indications of S-Amlodipine + Losartan potassiumN/ASpecial Precautions while taking S-Amlodipine + Losartan potassiumN/APregnancy Related InformationN/AOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for S-Amlodipine + Losartan potassiumN/AInteractions for S-Amlodipine + Losartan potassiumN/ATypical Dosage for S-Amlodipine + Losartan potassiumN/ASchedule of S-Amlodipine + Losartan potassiumN/AStorage Requirements for S-Amlodipine + Losartan potassiumN/AEffects of Missed Dosage of S-Amlodipine + Losartan potassiumN/AEffects of Overdose of S-Amlodipine + Losartan potassiumN/AS-Amlodipine
About S-AmlodipineCalcium Channel Blocker (dihydropyridine class), Anti hypertensive,anti angina.Mechanism of Action of S-AmlodipineS-Amlodipine, which is an enantiomer of Amlodipine; is a dihydropyridine Ca2+ channel blocker. It exerts it`s antihypertensive action through blocking the influx of Ca2+ ions through voltage gated L-type Calcium channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells and causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand and improves oxygen supply to myocardial cells. It directly dilates vascular smooth muscle and reduces hypertension.Pharmacokinets of S-AmlodipineN/AOnset of Action for S-AmlodipineN/ADuration of Action for S-AmlodipineN/AHalf Life of S-AmlodipineN/ASide Effects of S-Amlodipine1.Headache
2.Dizziness
3.Nausea
4.Abdominal pain
5.Fatigue
6.Flushing
7.Pruritus
8.Rash
9.Dyspnea
10.Dyspepsia
11.Muscle spasm
Contra-indications of S-Amlodipine1.Hyper sensitivity to the drug or other dihydropyridines
2.Hepatic impairment
Special Precautions while taking S-AmlodipineHepatic impairmentPregnancy Related InformationContraindicatedOld Age Related InformationN/ABreast Feeding Related InformationN/AChildren Related InformationN/AIndications for S-AmlodipineHypertensionInteractions for S-AmlodipineN/ATypical Dosage for S-Amlodipine2.5mg once dailySchedule of S-AmlodipineHStorage Requirements for S-AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.Effects of Missed Dosage of S-AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of S-AmlodipineGive supportive measures and symptomatic treatment.Losartan Potassium
About Losartan PotassiumAn angiotensin II receptor antagonist, Antihypertensive.Mechanism of Action of Losartan PotassiumIt is a competitive antagonist of angiotensin-2 at AT-1 receptor. It decreases peripheral resistance and lowers BP in hypertensive individuals. It blocks all overt actions of angiotensin-2 such as: - 1. Vasoconstriction, 2. Central & Peripheral sympathetic stimulus, 3. Release of aldosterone and adrenaline, 4. Salt and water reabsorption, 5. Central actions like thirst, vasopressin release, and growth promoting actions on heart and blood vessels.Pharmacokinets of Losartan PotassiumAbsorption: Well absorbed orally, but bioavailability is about 33% due to first pass metabolism.
Distribution: Distributed in to the body in a protein bound form, but there is no brain penetration.
Metabolism: Metabolized in the liver in to active carboxylic acid metabolite and other metabolites.
Excretion: Excreted through faeces and urine.
Onset of Action for Losartan Potassium1 hourDuration of Action for Losartan PotassiumN/AHalf Life of Losartan Potassium2 hours
Half life of active metabolite: 6 to 9 hours
Side Effects of Losartan Potassium1. Hypotension
2. Hyperkalemia
3. Headache
4. Breathlessness
5. Chest pain
6. Sore throat
7. Infections
8. Weakness
9. Dizziness
10. Elevated liver enzyme levels
11. Myalgia
12. Fetopathic
13. Precipitate renal failure in renal artery stenosis, and in insufficient renal blood flow
14. Rashes
15. Insomnia
16. Nightmares
Contra-indications of Losartan Potassium1. Hypersensitivity to the drugSpecial Precautions while taking Losartan Potassium1.Hepatic impairment
2.Renal impairment
3.Heart failure
4.Volume depleted individuals
5.Monitor serum potassium levels and avoid use along with potassium sparing diuretics
6. Avoid driving or operating heavy machinery during therapy
7. Avoid alcohol use during therapy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationContraindicatedChildren Related InformationContraindicatedIndications for Losartan Potassium1. HypertensionInteractions for Losartan PotassiumDiuretics, other antihypertensives: Potentiate the hypotensive effect of losartan.
Potassium sparing diuretics, potassium suppliments: Risk of hyperkalaemia.
NSAIDs: May blunt hypotensive effect of losartan.
Cytochrome P450 inhibitors like ketoconazole: Increase in AUC of losartan by 18 % but has no effect on its active metabolite.
Phenobarbital: Results in 20% reduction in AUC of losartan and its active metabolite.Typical Dosage for Losartan Potassium25 to 50mg once daily. Gradually increases up to 100mg once daily or as two divided doses.Schedule of Losartan PotassiumHStorage Requirements for Losartan PotassiumStore at room temperature at a range of 15 to 30 degree C. protect from moisture and store in a tightly closed container.Effects of Missed Dosage of Losartan PotassiumTake the missed dose as soon as remember; if it is the time of next dose then skip the missed dose and take the regular dose.Effects of Overdose of Losartan PotassiumTreatment is supportive and symptomatic.Home Delivery for S-Amlodipine + Losartan potassium in Your City
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S-Amlodipine + Losartan potassium is a generic medicine name and there are several brands available for it. Some of the brands for s-amlodipine + losartan potassium might be better known than s-amlodipine + losartan potassium itself. If the pharmacy that's willing to deliver medicines to your home doesn't have s-amlodipine + losartan potassium in stock, you can ask for one of the branded alternatives for s-amlodipine + losartan potassium.