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- Pharmacology For Amlodipine + Lisinopril
Amlodipine + Lisinopril Pharmacology
Amlodipine + Lisinopril
About Amlodipine + LisinoprilN/AMechanism of Action of Amlodipine + LisinoprilN/APharmacokinets of Amlodipine + LisinoprilN/AOnset of Action for Amlodipine + LisinoprilN/ADuration of Action for Amlodipine + LisinoprilN/AHalf Life of Amlodipine + LisinoprilN/ASide Effects of Amlodipine + LisinoprilN/AContra-indications of Amlodipine + LisinoprilN/ASpecial Precautions while taking Amlodipine + LisinoprilN/APregnancy Related InformationContraindicated since Amlodipine and Lisinopril are contraindicated in pregnancy.Old Age Related InformationN/ABreast Feeding Related InformationUse with caution; since Amlodipine and Lisinopril are used with caution in lactationChildren Related InformationN/AIndications for Amlodipine + LisinoprilAll grades of hypertension.
Interactions for Amlodipine + LisinoprilN/ATypical Dosage for Amlodipine + Lisinopril1 tab daily. (amlodipine 5 mg` lisinopril 5 mg)
Schedule of Amlodipine + LisinoprilN/AStorage Requirements for Amlodipine + LisinoprilN/AEffects of Missed Dosage of Amlodipine + LisinoprilN/AEffects of Overdose of Amlodipine + LisinoprilN/AAmlodipine
About AmlodipineCalcium Channel Blocker, Anti hypertensive,anti angina.Mechanism of Action of AmlodipineAmlodipine is a second generation dihydropyridine Ca channel blocker. It exerts it`s antihypertensive, antianginal actions through blocking the influx of Ca ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It markedly relax arterioles and milder effects on veins. They do not compromise haemodynamics and cerebral and renal perfusion.Pharmacokinets of AmlodipineAbsorption: Well absorbed orally, Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver, but there is no active metabolite.Onset of Action for AmlodipineSlowDuration of Action for Amlodipine24 hoursHalf Life of AmlodipineN/ASide Effects of Amlodipine1.Palpitation
2.Flushing
3.Nausea
4.Vomiting
5.Abdominal pain
6.Edema
7.Headache
8.Dizziness
9.Paresthesia
10.Light headedness
11.Fatigue
12.Aggravates myocardial ischaemia
13.Rashes
Contra-indications of Amlodipine1.Heart failure
2.Aortic stenosis
3.Hypersensitivity to the drug
4.Unstable angina
5.Hepatic impairment
6.Along with other anti hypertensive drugs.
Special Precautions while taking Amlodipine1.Cardiovascular disorders: Use cautiously in cardiovascular disorders because it aggravates myocardial ischaemia.
2.Sick sinus syndrome
3.Renal impairment
4.Use cautiously along with other antihypertensive drugs,
Pregnancy Related InformationContraindicated.Old Age Related InformationUse with cautionBreast Feeding Related InformationUse with caution.Children Related InformationContraindicatedIndications for Amlodipine1.Hypertension
2.Prinzmetal`s angina
3.Stable anginaInteractions for AmlodipineACE inhibitors, Thiazide diuretics: Potentiates effect of these drugs.
Beta Blockers: Best avoided, especially by those with impaired LV function due to depressant effect on myocardial contractibility or AV conduction.
Fentanyl: Severe hypotension or increased fluid volume requirements.Typical Dosage for Amlodipine5 mg once daily.
Maximum dose: 10mg/day
Prinzmetal`s angina and Stable angina:
5 to 10mg once daily.
Hypertension: 2.5 to 5mg once daily. Dose may increase up to 10mg once daily as required by the individual needs.
.Schedule of AmlodipineHStorage Requirements for AmlodipineStore at room temperature below 30 degree C. Protect from moisture and light.
Effects of Missed Dosage of AmlodipineTake the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.Effects of Overdose of AmlodipineMonitor &support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.Lisinopril
About LisinoprilDicarboxylate-containing Angiotensin-Converting Enzyme (ACE) Inhibitor, Antihypertensive.Mechanism of Action of LisinoprilIt is an angiotensin converting enzyme inhibitor prevents the conversion of angiotensin-1 to angiotensin-2 and abolishes the pressor actions of angiotensin. It decreases aldosterone secretion, sodium and water retention, and total peripheral resistance, leads to fall in BP. The arterioles dilate and the compliance of larger arteries is increased. Both systolic and diastolic BP is lowered. It has no effect on cardiac output and cardiovascular reflexes. There is little dilatation of capacitance vessels; so postural hypotension is not a problem. The drug does not compromise renal, cerebral, and coronary blood flow. BP lowering depending up on sodium status and renin angiotensin activity. So greater fall in BP occurs in Reno vascular accelerated and malignant hypertension. The drug also increases plasma kinin levels and potentiate the hypotensive action of exogenously administered bradykinin. It is used for treatment of systolic heart failure, because it improves symptoms, decrease mortality and reduce ventricular hypertrophy. It reduces both preload and after load and thus increasing cardiac out put in patients with heart failure.Pharmacokinets of LisinoprilAbsorption: Slowly absorbed orally about 25%.
Distribution: Widely distributed, but poor brain penetration.
Metabolism: Not metabolized in the body.
Excretion: Excreted unchanged in urine.
Onset of Action for Lisinopril1 hourDuration of Action for Lisinopril24 hoursHalf Life of Lisinopril12 hoursSide Effects of Lisinopril1. Cough
2. Angioedema
3. Hypotension
4. Chest pain
5. Hyperkalemia
6. Rashes
7. Urticaria
8. Swelling of lips mouth nose and larynx
9. Fetopathic in later half of pregnancy
10. Headache
11. Diarrhoea
12. Fatigue
13. Dizziness
14. Nausea
15. Acute renal failure is precipitated in renal artery stenosis
Contra-indications of Lisinopril1. Hypersensitivity to the drug
2. Renal artery stenosis
3. Aortic stenosis
4. Coarctation of aorta
Special Precautions while taking Lisinopril1.Renal impairment:
2.Cardiogenic shock
3.Severe heart failure
4.Anaesthesia
5.Surgery
6.Stops diuretics 2 to 3 days before therapy
Pregnancy Related InformationContraindicatedOld Age Related InformationUse with cautionBreast Feeding Related InformationUse with cautionChildren Related InformationContraindicatedIndications for Lisinopril1. Hypertension
2. Congestive heart failure
Interactions for LisinoprilAntacids : Decrease efficacy of Lisinopril.
Indomethacin : Reduces hypotensive effect.
Digoxin : Increases plasma digoxin levels.
Potassium preparations & Postassium sparing diuretics : Hyperkalaemia and increased risk of renal failure.
Lithium : Toxicity due to increased serum concentration of Lithium.
Immunosuppressive Drugs : Increased risk of bone marrow depression.
Antidepressants , Diuretics, Beta-Blockers, Phenothiazines : Enhance hypotensive effect.
Morphine : Enhanced analgesic effect and respiratory depression.
Typical Dosage for LisinoprilStarts with 2.5mg once daily. Increases the dose to 5 to 20mg once daily; depending on patient`s response if required.
Maximum dose: 40mg/day
Schedule of LisinoprilHStorage Requirements for LisinoprilStore at a temperature range of 15 to 30 degree C. in a well closed container and protect from moisture.Effects of Missed Dosage of LisinoprilN/AEffects of Overdose of LisinoprilTreatment is supportive and symptomatic. To remove drug from the body perform induced emesis and gastric lavage. Administer activated charcoal to reduce absorption. In severe cases haemodialysis is considered if required. Treatment includes I.V. infusion of normal saline solution.Home Delivery for Amlodipine + Lisinopril in Your City
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