Nitrendipine Pharmacology

Nitrendipine

About Nitrendipine

A Dihydropyridine calcium channel blocker, Antihypertensive,antiangina.

Mechanism of Action of Nitrendipine

Nitrendipine is a vasoselective long acting dihydropyridine Ca channel blocker. It exerts antihypertensive, antianginal actions through blocking the influx of Ca2+ ions through voltage gated L-type Ca channels to the peripheral vascular smooth muscle cells, Coronary smooth muscle cells and to the myocardial cells. Thus causes dilatation of vascular endothelium, decrease peripheral resistance, & reduce myocardial oxygen demand .It produces smooth muscle relaxant action by the release of nitric oxide from endothelium and thus inhibits cyclic AMP-phosphodiesterase enzyme and resulting in raised cyclic AMP in smooth muscle. Nitric oxide exerts anti atherosclerotic action.

Pharmacokinets of Nitrendipine

Absorption: Well absorbed orally, bioavailability is reduced due to first pass metabolism. Distribution: Widely distributed in a protein bound form, Metabolism: Metabolized in liver. Excretion: Excreted mainly through urine and small amount is excreted through faeces

Onset of Action for Nitrendipine

Half to one hour

Duration of Action for Nitrendipine

4 to 48hours

Half Life of Nitrendipine

N/A

Side Effects of Nitrendipine

1.Flushing
2.Palpitation
3.Hypotension
4.Nausea
5.Edema
6.Headache
7.Dizziness
8.Fatigue
9.Paraesthesia
10.Gastrointestinal disturbances

Contra-indications of Nitrendipine

1.Acute myocardial infarction
2.Heart failure
3.Aortic stenosis
4.Hypotension
5.Cardiogenic shock
6.Hypersensitivity to the drug
7.Unstable angina

Special Precautions while taking Nitrendipine

1.Congestive heart failure
2.Cardiovascular insufficiency
3.Hypotension
4.Left ventricular outflow obstruction
5.Hepatic impairment
6.Slowly withdraw the drug with caution
7.Use cautiously along with other antihypertensive drugs
8.Diabetes mellitus

Pregnancy Related Information

Use with caution.

Old Age Related Information

Use with caution.

Breast Feeding Related Information

Contraindicated.

Children Related Information

Contraindicated

Indications for Nitrendipine

1.Hypertension
2.Angina pectoris

Interactions for Nitrendipine

Beta-blockers: Synergistic action, reverses depression of cardiac function.
Quinidine: Plasma levels of quinidine reduced.
Theophylline, phenytoin: Increases plasma levels of nitrendipine.

Typical Dosage for Nitrendipine

Starts with 5 to 20mg once daily. Increased to 20mg twice daily if required.

Schedule of Nitrendipine

Storage Requirements for Nitrendipine

Store at room temperature below 30 degree C. Protect from moisture and avoid freezing.

Effects of Missed Dosage of Nitrendipine

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Nitrendipine

Monitor & support cardiac and respiratory functions. Measure the BP. Give cardiovascular support by elevating the limbs and maintaining fluid balance. Administer vasopressers like nor epinephrine and Calcium gluconate if required.

Home Delivery for Nitrendipine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nitrendipine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nitrendipine and other medicines and health products. Home delivery services for nitrendipine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nitrendipine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nitrendipine before they complete the sale. You can get this information while placing the order for nitrendipine with the pharmacy.

Nitrendipine is a generic medicine name and there are several brands available for it. Some of the brands for nitrendipine might be better known than nitrendipine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nitrendipine in stock, you can ask for one of the branded alternatives for nitrendipine.