Bisoprolol Pharmacology

Bisoprolol

About Bisoprolol
Beta1-selective adrenergic blocker, Antihypertensive.
Mechanism of Action of Bisoprolol
Bisoprolol is a cardio selective beta-1 adrenergic antagonist.It has negative chronotropic and negative inotropic effects on heart. It decreases oxygen consumption; cardiac work and aortic pressure. It decreases central sympathetic out flow and also decreases nor adrenaline and renin releases. The drug decreases BP in hypertensive individuals.
Pharmacokinets of Bisoprolol
Absorption: well absorbed orally, Distribution: Widely distributed. Metabolism: Metabolized in liver. Excretion: Excreted mainly through urine & a small portion is excreted through faeces.
Onset of Action for Bisoprolol
1 to 4hours
Duration of Action for Bisoprolol
24hours
Half Life of Bisoprolol
9 to12hours
Side Effects of Bisoprolol
1.Heart failure
2.Heart block
3.Nightmares
4.Gastrointestinal problems
5.Nausea
6.Tiredness
7.Sinus bradycardia
8.Depression
9.Rash
10.Hypotension
11Dizziness
12.Depression
13.Fatigue
14.Vomiting
15.Diarrhoea
16.Constipation
17.Headache
18.Bronhospasm
19.Sleep disturbances
20.Cold extremities
21.Rhinitis
22.Sinusitis
23.Edema
24.Impotence
25.Coughing
26.Myalgia
27.Arthralgia
Contra-indications of Bisoprolol
1.Hypersensitivity to the drug
2.Second or third degree heart block
3.Congestive heart failure
4.Cardiogenic shock
5.Sinus Bradycardia
6.Chronic obstructive pulmonary diseases
7.Bronchial asthma
9.Peripheral arteriolar disorders
10.Renal impairment.
Special Precautions while taking Bisoprolol
1.Left ventricular failure
2.Hepatic impairment
3.The drug should be gradually withdraw with caution
4.Respiratory disorders
5.Diabetes mellitus
6.General Anaesthesia
7.Thyrotoxicosis
8.Use with caution along with class-1 antiarrrythmic drugs & other anti hypertensive drugs.
Pregnancy Related Information
Use with caution
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Contraindicated
Indications for Bisoprolol
1.Hypertension
2.Coronary artery diseases
Interactions for Bisoprolol
Alcohol, Anxiolytics and Hypnotics, Cimetidine, Diuretics: Enhanced hypotensive effect.
Analgesics: NSAIDs antagonise hypotensive effect.
Antidiabetics: Enhanced hypoglycaemic effect.
Calcium channel blockers: Increase risk of bradycardia and AV block with diltiazem, severe hypotension and heart failure with verapamil, nifedipine.
Cardiac glycosides: Increased AV Block and brandycardia.
Cholinergics: Effects antagonised by bisoprolol.
Corticosteroids: Antagonism of hypotensive effect.
Sympathomimetics: Severe hypertension with adrenaline and noradrenaline.
Typical Dosage for Bisoprolol
2.5mg to 10mg 0nce daily depending upon the patient`s response
Maximum dose: 20mg/day
Schedule of Bisoprolol
H
Storage Requirements for Bisoprolol
Store at room temperature in a well closed container. Keep out of reach of children
Effects of Missed Dosage of Bisoprolol
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Bisoprolol
Treatment is supportive and symptomatic. After ingestion empty the stomach by induced emesis or gastric lavage. Administer activated charcoal to reduce absorption. . Treat Bradycardia with atropine. If required administer isoproterinol with caution; in heart block. Treat hypotension with glucagons and vasopressors like epinephrine. Treat cardiac failure with diuretics and cardiac glycosides. Treat Bronhospasm with isoproterinol and aminophylline. Treat hypoglycemia with glucose

Home Delivery for Bisoprolol in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including bisoprolol.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for bisoprolol and other medicines and health products. Home delivery services for bisoprolol may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take bisoprolol only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for bisoprolol before they complete the sale. You can get this information while placing the order for bisoprolol with the pharmacy.

Bisoprolol is a generic medicine name and there are several brands available for it. Some of the brands for bisoprolol might be better known than bisoprolol itself. If the pharmacy that's willing to deliver medicines to your home doesn't have bisoprolol in stock, you can ask for one of the branded alternatives for bisoprolol.