Metadoxine Pharmacology

Metadoxine

About Metadoxine
Pyridoxine-pyrrolidone carboxylate, In Alcohol-induced liver disease (accelerate ethanol metabolism).
Mechanism of Action of Metadoxine
Metadoxine is Pyridoxine pidolate. Metadoxine has a direct effect on alcohol metabolism. It accelerates the transformation of alcohol into acetaldehyde and is excreted in urine. It aids in preventing liver damage resulting from prolonged alcohol intake and helps in reversing fatty liver. It improves Alcohol metabolism and accelerates the elimination of alcohol from the blood. Metadoxine reduces the toxic effects of alcohol.
Antifibrotic agent: In hepatic stellate cells, Metadoxine prevents the collagen synthesis & reduces fibrosis.Metadoxine acts as an Antifibrotic agent
Metadoxine is a synthetic antioxidant, provides stronger antioxidant protection. Metadoxine, prevents the redox imbalance and tumor necrosis factor (TNF-a) one of the earliest event in hepatic damage
Metadoxine increases the cerebral release of GABA and acetylcholine and the cerebral levels of ATP. Metadoxine is therefore an antagonist of alcohol-metabolic effects and helps to restore normal neuropsychological behaviour.
Pharmacokinets of Metadoxine
Absorption: It is readily absorbed after oral administration. Distribution: It is mainly distributed in the body in protein bound form. It is stored primarily in the liver and to a lesser extent muscle and brain. Metabolism: It is metabolised in the liver.
Onset of Action for Metadoxine
N/A
Duration of Action for Metadoxine
N/A
Half Life of Metadoxine
N/A
Side Effects of Metadoxine
1.Neuropathy
2.Unstable gait
3.Drowsiness
4.Perioral numbness
5.Paresthesia
6.Numbness of feet
7.Somnolence
8.Sensory neuropathy
9.Ataxia
Contra-indications of Metadoxine
Hypersensitivity to Metadoxine
Special Precautions while taking Metadoxine
Prolonged use
Pregnancy Related Information
May be used
Old Age Related Information
May be used
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: Contraindicated
Indications for Metadoxine
1. An adjunct in the management of alcohol withdrawal
2.Fatty liver
3.Acute and chronic alcohol intoxication
Interactions for Metadoxine
N/A
Typical Dosage for Metadoxine
Oral
500mg 1 - 2 times daily.
Schedule of Metadoxine
N/A
Storage Requirements for Metadoxine
Store it at 15 - 30 degree C. Protect from moisture and heat.
Effects of Missed Dosage of Metadoxine
Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.
Effects of Overdose of Metadoxine
Give supportive measures and symptomatic treatment. The signs of overdose can be resolved by discontinuation (withdrawal) of the drug.

Home Delivery for Metadoxine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including metadoxine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for metadoxine and other medicines and health products. Home delivery services for metadoxine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take metadoxine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for metadoxine before they complete the sale. You can get this information while placing the order for metadoxine with the pharmacy.

Metadoxine is a generic medicine name and there are several brands available for it. Some of the brands for metadoxine might be better known than metadoxine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have metadoxine in stock, you can ask for one of the branded alternatives for metadoxine.