Desferrioxamine Pharmacology

Desferrioxamine

About Desferrioxamine
Antidote, Natural product from Streptomyces pilosus, An iron-Chelating Agent, anti-oxidant.
Mechanism of Action of Desferrioxamine
Desferrioxamine is a chelating agent. The chelating agents being antagonists compete with body ligands for the heavy metals. They usually have 2 or more reacting groups which can hold the metal from 2 sides to form a ring. These should have higher affinity for the toxic metal to be excreted than Ca 2+ which is readily available in plasma than in body fluids. They should also have higher affinity for the metal than the body ligands.

Desferrioxamine (3 hydroxy group) binds to ferric iron and preventing entering in to the further chemical reactions and forms water soluble iron complex and easily excreted in the urine and bile. It can also form chelating complex with aluminium and therefore used in the treatment of aluminium overload.
Pharmacokinets of Desferrioxamine
Absorption: Desferrioxamine is well absorbed after parenteral administration
Distribution: It is widely distributed in the body.
Metabolism: Only a very small amount of drug is metabolised by plasma enzymes.
Excretion: Most of the drugs are excreted mainly in urine and 1/3 rd off the drug through faeces
Onset of Action for Desferrioxamine
N/A
Duration of Action for Desferrioxamine
N/A
Half Life of Desferrioxamine
N/A
Side Effects of Desferrioxamine
1 Nausea
2.Vomiting
3.Diarrhoea
4.Abdominal discomfort
5.Blurred vision
6.Tachycardia
7.Hearing problems
8.Visual field defect
9.Dysuria
10.Hypersensitivity reactions
11.Erythema
12.Pruritis
13.Rashes
14.Urticaria
15.Hypotension
16.Pain at the site of injection
Contra-indications of Desferrioxamine
1.Hypersensitivity to Desferrioxamine
2.Severe renal diseases
3.Anuria

Special Precautions while taking Desferrioxamine
1 Renal impairment
2.Monitor renal, vision and hearing function throughout the therapy,
Pregnancy Related Information
Contraindicated
Old Age Related Information
Use with caution
Breast Feeding Related Information
Use with caution
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Desferrioxamine
1.Iron poisoning
2.Aluminium poisoning
Interactions for Desferrioxamine
N/A
Typical Dosage for Desferrioxamine
Adult:
Oral: 5-10 g in 50 - 100 ml water following gastric lavage
PARENTERAL (IM or IV)
Treatment of acute iron poisoning:
In severe cases (in shock): 10 - 15 mg/kg /hour as IV infusion up to a maximum of 80mg / kg in 1 day.
In less severe cases (without shock): 40mg/kg as IM injection every 4 - 12 hours.
Hemochromatosis (IV infusion) 2 g for 12 hours as IV infusion
Aluminium overload (in patients with end stage renal failure and in patient on peritoneal dialysis): 5 mg/kg as slow IV infusion once a week during the last hour of dialysis.

Schedule of Desferrioxamine
N/A
Storage Requirements for Desferrioxamine
Store at room temperature (15 - 25 degree C). Protect from heat and light. Keep out of the reach of children
Effects of Missed Dosage of Desferrioxamine
Do not apply.
It is usually given by health care professionals.
Effects of Overdose of Desferrioxamine
Give supportive measures and symptomatic treatment. Haemodialysis can be done in emergency conditions.

Home Delivery for Desferrioxamine in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including desferrioxamine.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for desferrioxamine and other medicines and health products. Home delivery services for desferrioxamine may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take desferrioxamine only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for desferrioxamine before they complete the sale. You can get this information while placing the order for desferrioxamine with the pharmacy.

Desferrioxamine is a generic medicine name and there are several brands available for it. Some of the brands for desferrioxamine might be better known than desferrioxamine itself. If the pharmacy that's willing to deliver medicines to your home doesn't have desferrioxamine in stock, you can ask for one of the branded alternatives for desferrioxamine.