Permethrin Pharmacology

Permethrin

About Permethrin
Synthetic Pyrethroid , Antiparasitic Pediculicide, scabicide.
Mechanism of Action of Permethrin
Permethrin exerts its action by inhibiting sodium ion channel and delays depolarization. This will leads to (neuronal) paralysis of insects.
Permethrin kills insects by strongly exciting their nervous systems. It makes the nervous system hypersensitive to stimuli from sense organs. Instead of sending a single impulse in response to a stimulus, Permethrin-exposed nerves send a series of impulses. This excitation occurs because Permethrin blocks the movement of sodium ions from outside to inside of the nerve cells. It is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.
Pharmacokinets of Permethrin
Absorption: Small amount of the drug is absorbed (less than 2%) after topical application.
Onset of Action for Permethrin
N/A
Duration of Action for Permethrin
N/A
Half Life of Permethrin
N/A
Side Effects of Permethrin
1. Burning
2. Stinging
3. Oedema
4. Tingling
5. Numbness
6. Pruritis
7. Mild Erythema
8. Rashes
Contra-indications of Permethrin
1.Hypersensitivity to Permethrin
Special Precautions while taking Permethrin
1.Avoid contact with mucous membrane, eye
2.For external use only
3.If irritation persist consult physician
Pregnancy Related Information
Use with caution.
Old Age Related Information
Use with caution.
Breast Feeding Related Information
Use with caution.
Children Related Information
Use with caution
NEONATES: contraindicated
Indications for Permethrin
1.Pediculosis
2.Scabies
Interactions for Permethrin
N/A
Typical Dosage for Permethrin
Topical:
Pediculosis: 1% applies the medicament on the hair, kept for 10 minutes and rinse thoroughly with water.
Scabies: 5% cream apply the medicament with through massage from head to soles and remove cream after 8 - 14 hours.
Schedule of Permethrin
N/A
Storage Requirements for Permethrin
Store at 15 - 25 degree C. Keep out of the reach of children
Effects of Missed Dosage of Permethrin
Topical application is only once.
Effects of Overdose of Permethrin
Give supportive measures and symptomatic treatment. For accidental ingestion drug can be removed by gastric lavage.

Home Delivery for Permethrin in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including permethrin.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for permethrin and other medicines and health products. Home delivery services for permethrin may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take permethrin only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for permethrin before they complete the sale. You can get this information while placing the order for permethrin with the pharmacy.

Permethrin is a generic medicine name and there are several brands available for it. Some of the brands for permethrin might be better known than permethrin itself. If the pharmacy that's willing to deliver medicines to your home doesn't have permethrin in stock, you can ask for one of the branded alternatives for permethrin.