Nitazoxanide Pharmacology

Nitazoxanide

About Nitazoxanide

A synthetic nitrothiazolyl-salicylamide derivative, Antihelminthics ,in schistosomiasis.

Mechanism of Action of Nitazoxanide

It excerts its action by blocking anaerobic energy metabolism. The drug interfering with the pyruvate-ferredoxin oxidoreductase enzyme depended electron transfer reaction which is an essential step in anaerobic glucose energy metabolism.

Pharmacokinets of Nitazoxanide

Absorption: Well absorbed orally, food increases bioavailability, Distribution: Distributed in a protein bound form, Metabolism: Metabolized in to an active metabolite tizoxanide and then tizoxanide undergoes glucurunide conjugation Excretion: Excreted mainly through bile and faeces and the remaining portion through urine.

Onset of Action for Nitazoxanide

1 to 4 hours

Duration of Action for Nitazoxanide

N/A

Half Life of Nitazoxanide

N/A

Side Effects of Nitazoxanide

1.Nausea
2.Dizziness
3.Altered appetite
4.Enlarged salivary gland
5.Pruritis
6.Malaise
7.Fever
8.Altered renal function test
9.Elevated liver enzyme level

Contra-indications of Nitazoxanide

1.Hypersensitivity to the drug

Special Precautions while taking Nitazoxanide

1.Cardiovascular disorder
2.Diabetes

Pregnancy Related Information

Contraindicated

Old Age Related Information

N/A

Breast Feeding Related Information

Contraindicated

Children Related Information

N/A

Indications for Nitazoxanide

1.Helminthiasis
2.Giardiasis
3.Amoebiasis
4.Trichomoniasis
5.Fasciolasis
6.Cryptosporidiosis

Interactions for Nitazoxanide

Caution should be exercised while administering nitazoxanide with drugs which are highly plasma bound.

Typical Dosage for Nitazoxanide

As anthelminthic and antiprotozoal:
0.5gm 12hourly along with food for 3days, In Fasciolasis same dosage for a week
Cryptosporidiosis: o.5 gm once a day for 3days

Schedule of Nitazoxanide

Storage Requirements for Nitazoxanide

The drug should be kept at 15 - 30 degree C in a tightly closed container. Keep out of the reach of children.

Effects of Missed Dosage of Nitazoxanide

Take the missed dose as soon as noticed and if it is the time for next dose then skip the missed dose. Continue the regular schedule. Do not double the dose.

Effects of Overdose of Nitazoxanide

Give support and symptomatic treatment.

Home Delivery for Nitazoxanide in Your City

Medicine India is just a publishing medium for medicine related information and does not provide services or sales of medicines including nitazoxanide.

However, we do publish a comprehensive directory of Pharmacies, Chemists and Druggists in cities all over India. You can use this directory to find the medicine stores in your city (or area) that provide home delivery services for nitazoxanide and other medicines and health products. Home delivery services for nitazoxanide may be free or they may cost you depending on the pharmacy and the minimum order requirements. It would be best to get this clarified while placing the order.

Please be aware that you should take nitazoxanide only if a doctor has recommended or prescribed it. Some or all pharmacies who provide a home delivery service for medicines might insist on a prescription for nitazoxanide before they complete the sale. You can get this information while placing the order for nitazoxanide with the pharmacy.

Nitazoxanide is a generic medicine name and there are several brands available for it. Some of the brands for nitazoxanide might be better known than nitazoxanide itself. If the pharmacy that's willing to deliver medicines to your home doesn't have nitazoxanide in stock, you can ask for one of the branded alternatives for nitazoxanide.